Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
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Background Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored.Objective The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST).Design Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks.Results Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66).Conclusion These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.
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Three fatty acids-oleic acid, α-linolenic acid, and dihomo-γ-linolenic acid-were found to be associated with the risk of gastric cancer.
“Three fatty acids-oleic acid, a-linolenic acid, and di-homo-g-linolenic acid-were found to be associated with the risk of gastric cancer (169).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [169]
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Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies
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Plasma Phospholipid Fatty Acid Profiles in Septic Shock
Caspar‐Bauguil, S., & Genestal, M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8503-2_137-1
DISERTACIÓN PREVIA A LA OBTENCIÓN DEL TÍTULO DE
Medicina, F. D., & Cirujano, M. (2013)
Early Biomarkers in Breast Cancer
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Early Biomarkers in Breast Cancer
Raina, P. (2013) · CRC Press eBooks · doi:10.1201/b16389-28
Cancer, Heart Diseases and Common Risk Factors: Diet and Physical Activity
Tralongo, P., Lestuzzi, C., & Furlanello, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-40236-9_3
Systematic review of current evidence on metabolites associated with gastric cancer
Hoang, T., Keski‐Rahkonen, P., Jenab, M., Knaze, V., Shin, A., & Park, J. Y. (2026) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djag053
Self-citation
- Authors
- Chajès, V., Jenab, M., Romieu, I., Ferrari, P., Dahm, C. C., Overvad, K., Egeberg, R., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Engel, P., Teucher, B., Kaaks, R., Floegel, A., Boeing, H., Trichopoulou, A., Dilis, V., Karapetyan, T., Mattiello, A., Tumino, R., Grioni, S., Palli, D., Vineis, P., Bueno-de-Mesquita, H. B., Numans, M. E., Peeters, P. H., Lund, E., Navarro, C., Quirós, J. R., Sánchez-Cantalejo, E., Gurrea, A. B., Dorronsoro, M., Regnér, S., Sonestedt, E., Wirfält, E., Khaw, K.-T., Wareham, N., Allen, N. E., Crowe, F. L., Rinaldi, S., Slimani, N., Carneiro, F., Riboli, E., & González, C. A.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- ORCID
- Chajès, Véronique
- Jenab, Mazda
- Romieu, Isabelle
- Ferrari, Pietro
- Dahm, Christina C
- Overvad, Kim
- Tjønneland, Anne
- Kaaks, Rudolf
- Floegel, Anna
- Trichopoulou, Antonia
- Mattiello, Amalia
- Tumino, Rosario
- Grioni, Sara
- Palli, Domenico
- Vineis, Paolo
- Numans, Mattijs E
- Peeters, Petra HM
- Lund, Eiliv
- Navarro, Carmen
- Regnér, Sara
- Sonestedt, Emily
- Khaw, Kay-Tee
- Crowe, Francesca L
- Rinaldi, Sabina
- Slimani, Nadia
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 94
- Issue
- 5
- Pages
- 1304-1313
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2161607933
- Cited by
- 51
- References
- 58
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Cancer Research UK
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- gastric adenocarcinoma, plasma phospholipid fatty acids, dietary fatty acids, oleic acid, alpha-linolenic acid, dihomo-gamma-linolenic acid, stearoyl-CoA desaturase 1, fatty acid metabolism, cancer risk biomarkers, Helicobacter pylori
- MeSH terms
- Adenocarcinoma, Adult, Aged, Europe, Fatty Acids, Female, Humans, Male, Middle Aged, Phospholipids, Surveys and Questionnaires, Risk Factors, Stomach Neoplasms, Cohort Studies, Logistic Models, Case-Control Studies
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