The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001–2006
Open accessAbstract
Background The effect of assay drifts over time on serum 25-hydroxyvitamin D [25(OH)D] concentrations were not accounted for in previous national survey studies. Thus, previously reported associations between 25(OH)D with cardiometabolic risk factors using data from NHANES were likely over- or underestimated. Moreover, associations between serum 25(OH)D and metabolic syndrome (MetSyn), insulin resistance (IR), and inflammation are unclear in children.Objective The relation between serum 25(OH)D and cardiometabolic risk factors in US children was investigated by using updated 25(OH)D data.Design This study was based on newly updated serum 25(OH)D data, which were released by the National Center for Health Statistics in November 2010. Data from 3 cycles of NHANES (2001-2002, 2003-2004, and 2005-2006) for 5867 adolescents, aged 12-19 y, were used to study the association, by multivariate-adjusted regression, between serum 25(OH)D and prevalence of MetSyn and several cardiometabolic risk factors.Results The likelihood of having MetSyn was significantly higher in the first tertile of serum 25(OH)D than in the third tertile of 25(OH)D (odds ratio: 1.71; 95% CI: 1.11, 2.65; P < 0.01). Waist circumference (P < 0.0001), systolic blood pressure (P = 0.01), and homeostatic model assessment-insulin resistance index (P = 0.001) were inversely related and HDL cholesterol (P < 0.0001) was directly related with serum 25(OH)D. No association was observed between 25(OH)D and C-reactive protein (P = 0.18).Conclusions On the basis of assay-adjusted data, serum 25(OH)D was significantly associated with several cardiometabolic risk factors regardless of obesity. In children, given the negative outcomes associated with poor vitamin D status and MetSyn, consideration of vitamin D supplementation in reversing cardiometabolic risk factors appears to be warranted.
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“AGE may also be derived from food (454,461) or tobacco (462) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [461]
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Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
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Chiu, K. C., Chu, A. Y., Go, V. L. W., & Saad, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.820 · Cited by 1,648
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Analysis of Association between Vitamin D Deficiency and Insulin Resistance
Szymczak-Pajor, I., & Śliwińska, A. (2019) · Nutrients · doi:10.3390/nu11040794 · Cited by 350
Prevalence of Vitamin D Deficiency Among Overweight and Obese US Children
Turer, C. B., Lin, H., & Flores, G. (2012) · PEDIATRICS · doi:10.1542/peds.2012-1711 · Cited by 313
Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Shaw, J. E., Zimmet, P., Sikaris, K. A., Ebeling, P. R., & Daly, R. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3187 · Cited by 255
Focus on Vitamin D, Inflammation and Type 2 Diabetes
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Metadata
- Authors
- Ganji, V., Zhang, X., Shaikh, N., & Tangpricha, V.
- Affiliations
- Emory University (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 94
- Issue
- 1
- Pages
- 225-233
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2118926394
- Cited by
- 189
- References
- 59
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 13 · 2018: 14 · 2017: 18 · 2016: 13 · 2015: 12 · 2014: 9 · 2013: 17 · 2012: 30
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- 25-hydroxyvitamin D, vitamin D status, metabolic syndrome, cardiometabolic risk factors, children and adolescents, insulin resistance, waist circumference, systolic blood pressure, HDL cholesterol, C-reactive protein, inflammation, obesity, NHANES, vitamin D supplementation, vitamin D deficiency, vitamin D excess, cardiovascular disease prevention, diabetes prevention
- MeSH terms
- Adolescent, Adult, Cardiovascular Diseases, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Health Surveys, Humans, Insulin Resistance, Cholesterol, HDL, Male, Risk Factors, Time Factors, Vitamin D, Prevalence, Metabolic Syndrome
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