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Effects of weight loss on serum vitamin D in postmenopausal women
Open accessAbstract
Background Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.Objective The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.Design Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.Results No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost <5%, 5-9.9%, 10-14.9%, or ≥15% of baseline weight had mean increases in 25(OH)D of 2.1, 2.7, 3.3, and 7.7 ng/mL, respectively (P for trend = 0.002). Baseline vitamin D status did not modify the effect of the interventions on weight loss or body-composition changes at the 12-mo follow-up.Conclusion A greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating 25(OH)D concentrations. This trial is registered at clinicaltrials.gov as NCT00470119.
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“A meta-analysis reported a modest positive effect of vitamin D supplementation on muscle strength in elderly individuals with deficiency, but no effect on muscle mass, nor on muscle preservation during caloric restriction [57, 58].”
From Muscle loss and GLP-1R agonists use (2025) · cites this paper as [58]
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Self-citation
Metadata
- Authors
- Mason, C., Xiao, L., Imayama, I., Duggan, C. R., Bain, C., Foster-Schubert, K. E., Kong, A., Campbell, K. L., Wang, C.-Y., Neuhouser, M. L., Li, L., W Jeffery, R., Robien, K., Alfano, C. M., Blackburn, G. L., & McTiernan, A.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- McTiernan, Anne
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 94
- Issue
- 1
- Pages
- 95-103
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC3127511
- OpenAlex
- W2159713326
- Cited by
- 116
- References
- 44
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 11
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University
- National Institutes of Health (5kl2rr025015-03, NIH-R01, NIH U54, R25 CA94880)
- Canadian Institutes of Health Research
- National Cancer Institute (R25CA057699, R01CA102504, R25 CA 94880, R01CA105204, CA94880, CA116847, U54CA116847, CA102504, R25CA094880)
- National Center for Research Resources (5 KL2 RR025015-03)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- vitamin D, 25-hydroxyvitamin D, weight loss, postmenopausal women, obesity, overweight, caloric restriction, dietary change, aerobic exercise, body composition, vitamin D status
- MeSH terms
- Aged, Female, Humans, Middle Aged, Sunlight, Vitamin D, Weight Loss, Exercise, Postmenopause, Caloric Restriction
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