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Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials
Open accessAbstract
Background The effect of green tea catechins (GTCs) with or without caffeine on glycemic control is controversial.Objective We aimed to identify and quantify the effects of GTCs or GTC-caffeine mixtures on glucose metabolism in adults.Design A comprehensive literature search was conducted to identify relevant trials of GTCs with or without caffeine on markers of glycemic control [fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (Hb A1c), and homeostatic model assessment of insulin resistance (HOMA-IR)]. Weighted mean differences were calculated for net changes by using fixed-effects models. Prespecified subgroup analyses were performed to explore the influence of covariates on net changes in FBG and FBI concentrations.Results Twenty-two eligible randomized controlled trials with 1584 subjects were identified. Pooled analyses showed that FBG (-1.48 mg/dL; 95% CI: -2.57, -0.40 mg/dL) decreased significantly with GTCs with or without caffeine, whereas FBI (0.04 μU/mL; 95% CI: -0.36, 0.45 μU/mL), Hb A1c (-0.04%; 95% CI: -0.15, 0.08%), and HOMA-IR (-0.05; 95% CI: -0.37, 0.26) did not. Subgroup analyses indicated that the glucose-lowering effect was apparent when the duration of follow-up was over a median of 12 wk. Overall, no significant heterogeneity was detected for FBG, FBI, Hb A1c, or HOMA-IR.Conclusions The meta-analysis showed that the administration of GTCs with or without caffeine resulted in a significant reduction in FBG. The limited data available on GTCs did not support a positive effect on FBI, Hb A1c, or HOMA-IR. Thus, more large and well-designed trials are needed in the future. This trial was registered at http://www.crd.york.ac.uk/prospero as CRD42012002139.
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“Others have also found cardiometabolic improvement effects of anthocyanin,32 catechin,33,34 curcumin,35 flavanol,36 genistein,37 and quercetin.38,39”
From Micronutrient Supplementation to Reduce Cardiovascular Risk (2022) · cites this paper as [33]
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Metadata
- Authors
- Zheng, X.-X., Xu, Y.-L., Li, S.-H., Hui, R., Wu, Y.-J., & Huang, X.-H.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- ORCID
- Hui, Rutai
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 97
- Issue
- 4
- Pages
- 750-762
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2137040425
- Cited by
- 146
- References
- 69
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 13 · 2018: 11 · 2017: 15 · 2016: 13 · 2015: 7 · 2014: 9 · 2013: 8
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- green tea catechins, caffeine, glycemic control, fasting blood glucose, fasting insulin, HbA1c, insulin resistance, glucose metabolism, type 2 diabetes
- MeSH terms
- Adult, Blood Glucose, Caffeine, Catechin, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Insulin Resistance, Phytotherapy, Metabolic Diseases, Plant Extracts, Camellia sinensis
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