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Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies
Open accessAbstract
Background Replacement of caloric sweeteners with lower- or no-calorie alternatives may facilitate weight loss or weight maintenance by helping to reduce energy intake; however, past research examining low-calorie sweeteners (LCSs) and body weight has produced mixed results.Objective The objective was to systematically review and quantitatively evaluate randomized controlled trials (RCTs) and prospective cohort studies, separately, that examined the relation between LCSs and body weight and composition.Design A systematic literature search identified 15 RCTs and 9 prospective cohort studies that examined LCSs from foods or beverages or LCSs consumed as tabletop sweeteners. Meta-analyses generated weighted mean differences in body weight and composition values between the LCS and control groups among RCTs and weighted mean correlations for LCS intake and these parameters among prospective cohort studies.Results In RCTs, LCSs modestly but significantly reduced all outcomes examined, including body weight (-0.80 kg; 95% CI: -1.17, -0.43), body mass index [BMI (in kg/m²): -0.24; 95% CI: -0.41, -0.07], fat mass (-1.10 kg; 95% CI: -1.77, -0.44), and waist circumference (-0.83 cm; 95% CI: -1.29, -0.37). Among prospective cohort studies, LCS intake was not associated with body weight or fat mass, but was significantly associated with slightly higher BMI (0.03; 95% CI: 0.01, 0.06).Conclusions The current meta-analysis provides a rigorous evaluation of the scientific evidence on LCSs and body weight and composition. Findings from observational studies showed no association between LCS intake and body weight or fat mass and a small positive association with BMI; however, data from RCTs, which provide the highest quality of evidence for examining the potentially causal effects of LCS intake, indicate that substituting LCS options for their regular-calorie versions results in a modest weight loss and may be a useful dietary tool to improve compliance with weight loss or weight maintenance plans.
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“There is mixed evidence from systematic reviews and meta-analyses for nonnutritive sweetener use with regard to weight management, with some finding benefit in weight loss (233-235) while other research suggests an association with weight gain (236,237).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [233]
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,762
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523
Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.
Ogden, C., Carroll, M., Kit, B., & Flegal, K. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.40 · Cited by 4,128
Intake of sugar-sweetened beverages and weight gain: a systematic review
Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100
Research works printed but not linked: 2
- 2011, Commission Regulation (EU) No 1129/2011 of 11 November 2011 amending Annex II to Regulation (EC) No 1333/2008 of the European Parliament and of the Council by establishing a Union list of food additives, Offic J European Union, 54, 1
- 2012, Offic J European Union, 310, 45
Cited by
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Items 101–200 of 312
Grech, A. L., Kam, C., Gemming, L., & Rangan, A. (2018) · Nutrients · doi:10.3390/nu10070833 · Cited by 32
Perspective: Standards for Research and Reporting on Low-Energy (“Artificial”) Sweeteners
Mela, D. J., McLaughlin, J. T., & Rogers, P. J. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz137 · Cited by 32
POINT: Artificial Sweeteners and Obesity—Not the Solution and Potentially a Problem
Christofides, E. A. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.08.001 · Cited by 32
Stern, D., Middaugh, N. A., Rice, M. S., Laden, F., López‐Ridaura, R., ROSNER, B. A., Willett, W. C., & Lajous, M. (2017) · American Journal of Public Health · doi:10.2105/ajph.2017.304008 · Cited by 35
Low-calorie sweeteners in food and food supplements on the Italian market
Janvier, S., Goscinny, S., Donne, C. L., & Loco, J. V. (2015) · Food Additives and Contaminants Part B · doi:10.1080/19393210.2015.1094829 · Cited by 31
Villaño, D., Masoodi, H., Marhuenda, J., García‐Viguera, C., & Zafrilla, P. (2021) · LWT · doi:10.1016/j.lwt.2021.111173 · Cited by 31
BoostSweet: Learning molecular perceptual representations of sweeteners
Lee, J. H., Song, S. B., Chung, Y. K., Jang, J. H., & Huh, J. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132435 · Cited by 29
What can the food and drink industry do to help achieve the 5% free sugars goal?
Gibson, S. A., Ashwell, M., Arthur, J. R., Bagley, L., Lennox, A., Rogers, P. J., & Stanner, S. A. (2017) · Perspectives in Public Health · doi:10.1177/1757913917703419 · Cited by 30
Hinkle, S. N., Rawal, S., Bjerregaard, A. A., Halldorsson, T. I., Li, M., Ley, S. H., Wu, J., Zhu, Y., Chen, L., Liu, A., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz094 · Cited by 28
Steffen, B. T., Jacobs, D. R., Yi, S.-Y. Y., Lees, S. J., Shikany, J. M., Terry, J. G., Lewis, C. E., Carr, J. J., Zhou, X., & Steffen, L. M. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01336-y · Cited by 28
Consensus statement on benefits of low‐calorie sweeteners
Gibson, S. A., Drewnowski, A., Hill, J. O., Raben, A., Tuorila, H., & Widström, E. (2014) · Nutrition Bulletin · doi:10.1111/nbu.12116 · Cited by 28
Sievenpiper, J. L., Purkayastha, S., Grotz, V. L., Mora, M. R., Zhou, J., Hennings, K., Goody, C. M., & Germana, K. (2025) · Nutrients · doi:10.3390/nu17050793 · Cited by 27
Harrold, J. A., Hill, S., Radu, C. C. P., Thomas, P., Thorp, P., Hardman, C. A., Christiansen, P., & Halford, J. C. G. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01393-3 · Cited by 27
Leahy, M., Ratliff, J. C., Riedt, C. S., & Fulgoni, V. L. I. (2017) · Nutrients · doi:10.3390/nu9090928 · Cited by 27
Rogers, P. J., Ferriday, D., Irani, B., Hoi, J. K. H., England, C. Y., Bajwa, K. K., & Gough, T. (2020) · Appetite · doi:10.1016/j.appet.2020.104631 · Cited by 28
Nonalcoholic fatty liver disease, insulin resistance, and sweeteners: a literature review
Kakleas, K., Christodouli, F., & Karavanaki, K. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1740588 · Cited by 26
Alsunni, A. A. (2020) · International Journal of General Medicine · doi:10.2147/ijgm.s274760 · Cited by 26
Low-calorie sweeteners and human health: a rapid review of systematic reviews
Andrade, L., Lee, K. M., Sylvetsky, A. C., & Kirkpatrick, S. I. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa123 · Cited by 31
Added sugars: Definitions, classifications, metabolism and health implications
Scapin, T., Fernandes, A. C., & Proença, R. P. D. C. (2017) · Revista de Nutrição · doi:10.1590/1678-98652017000500011 · Cited by 28
Solomi, L., Rees, G. A., & Redfern, K. M. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1585418 · Cited by 25
Non-nutritive Sweeteners and Glycaemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0814-6 · Cited by 30
Nadolsky, K. Z. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.06.013 · Cited by 29
Tey, S. L., Salleh, N. B., Henry, C. J., & Forde, C. G. (2018) · Nutrients · doi:10.3390/nu10020161 · Cited by 26
ÖRKÜ, Ş. E., Süyen, G. G., & Baş, M. (2022) · Nutrition · doi:10.1016/j.nut.2022.111885 · Cited by 25
Effects of different sweeteners on behavior and neurotransmitters release in mice
Yin, K., Xie, D., Zhao, L., Fan, G., Ren, J., Zhang, L., & Pan, S. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-04036-6 · Cited by 23
Hunt, K. J., Peter, J. V. S., Malek, A. M., Vrana-Diaz, C. J., Marriott, B. P., & Greenberg, D. (2020) · Nutrients · doi:10.3390/nu12092566 · Cited by 23
Lee, H. Y., Jack, M. M., Poon, T. H., Noori, D., Venditti, C. C., Hamamji, S., & Musa‐Veloso, K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa157 · Cited by 22
Russell, C., Dickie, S., Baker, P., & Lawrence, M. A. (2021) · Nutrients · doi:10.3390/nu13030898 · Cited by 23
Gentil, P. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0111-x · Cited by 22
Yeung, A. W. K., & Wong, N. S. M. (2020) · Nutrients · doi:10.3390/nu12103010 · Cited by 21
Mahfouz, A. A., Alsaleem, S. A., Alsaleem, M. A., & Ghazy, R. M. (2024) · Medicina · doi:10.3390/medicina60030347 · Cited by 21
Samaniego-Vaesken, M. D. L., Partearroyo, T., Cano, A. G., Urrialde, R., & Varela‐Moreiras, G. (2019) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2019.103234 · Cited by 21
Low-energy sweeteners and body weight: a citation network analysis
Normand, M., Ritz, C., Mela, D. J., & Raben, A. (2021) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000210 · Cited by 22
The Battle of Natural Sweeteners: A Comprehensive Guide to Monk Fruit and Stevia
Wazir, M., Verma, H., Singh, J., Singh, P., & Passey, S. (2025) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.13.1.2 · Cited by 20
Gallagher, A. M., Ashwell, M., Halford, J. C. G., Hardman, C. A., Maloney, N. G., & Raben, A. (2021) · Journal of Nutritional Science · doi:10.1017/jns.2020.59 · Cited by 23
Challenges and opportunities in the use of low‐energy sugar replacers
Buttriss, J. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12258 · Cited by 20
Low calorie sweeteners: Science and controversy
Mattes, R. D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.005 · Cited by 19
Wicks, M., Wright, H. H., & Wentzel‐Viljoen, E. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516004244 · Cited by 19
Romo-Romo, A., Aguilar-Salinas, C. A., López-Carrasco, M. G., Guillén-Pineda, L. E., Brito-Córdova, G. X., Gómez-Díaz, R. A., Gomez-Perez, F. J., & Almeda‐Valdés, P. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.03.018 · Cited by 19
Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity
Morissette, A., d’Oplinter, A. D. W., André, D. M., Lavoie, M., Marcotte, B., Varin, T. V., Trottier, J., Pilon, G., Pelletier, M., Cani, P. D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53587-y · Cited by 19
Kendig, M. D., Fu, M. X., Rehn, S., Martire, S. I., Boakes, R. A., & Rooney, K. B. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.008 · Cited by 18
Interactions of Non-Nutritive Artificial Sweeteners with the Microbiome in Metabolic Syndrome
Harrington, V. M., +, L. L., Crits‐Christoph, A., & Suez, J. (2022) · Immunometabolism · doi:10.20900/immunometab20220012 · Cited by 22
Logue, C., Dowey, L. R. C., Strain, J., Verhagen, H., & Gallagher, A. M. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115004310 · Cited by 20
Sickeningly Sweet: Does Sugar Cause Chronic Disease? No
Sievenpiper, J. L. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.05.006 · Cited by 19
Finding the Sweet Spot: Measurement, Modification, and Application of Sweet Hedonics in Humans
Cheon, E., Reister, E. J., Hunter, S., & Mattes, R. D. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab055 · Cited by 17
Mosdøl, A., Vist, G. E., Svendsen, C., Dirven, H. A. A. M., Lillegaard, I. T., Mathisen, G. H., & Husøy, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199558 · Cited by 20
Mehat, K., Chen, Y., & Corpe, C. P. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac072 · Cited by 16
Chen, Z., Cheng, W., Lamballais, S., Wang, K., Mou, Y., Xiao, Y., Luo, F., Bramer, W. M., Voortman, T., & Zhou, S. (2024) · Nutrition Journal · doi:10.1186/s12937-024-00985-7 · Cited by 16
Gil‐Campos, M., González, M. A. S. J., & Díaz, J. J. (2015) · Anales de Pediatría · doi:10.1016/j.anpedi.2015.02.013 · Cited by 16
Durán‐Agüero, S., Cornwall, J. R., Vega, C. E., de Ariza, J. S., Arrivillaga, K. R. C., Bujaico, M. D. P. C., Alzamora, S., & Espinoza-Bernardo, S. L. (2014) · PubMed · doi:10.3305/nh.2015.31.2.8026 · Cited by 18
Gil‐Campos, M., González, M. A. S. J., & Díaz, J. J. (2015) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2015.10.002 · Cited by 16
Bright, O.-J. M., Wang, D. D., Shams‐White, M., Bleich, S. N., Foreyt, J. P., Franz, M. J., Johnson, G., Manning, B. T., Mattes, R. D., Pi‐Sunyer, X., et al. (2017) · Current Developments in Nutrition · doi:10.3945/cdn.117.000547 · Cited by 17
Low-Calorie Beverage Consumption, Diet Quality and Cardiometabolic Risk Factors in British Adults
Patel, L., Alicandro, G., & Vecchia, C. L. (2018) · Nutrients · doi:10.3390/nu10091261 · Cited by 15
Mathur, P., & Bakshi, A. (2023) · Nutrition & Food Science · doi:10.1108/nfs-03-2023-0060 · Cited by 14
Russell, C., Baker, P., Grimes, C. A., & Lawrence, M. A. (2022) · Public Health Nutrition · doi:10.1017/s1368980022000234 · Cited by 16
Masic, U., Harrold, J. A., Christiansen, P., Cuthbertson, D. J., Hardman, C. A., Robinson, E., & Halford, J. C. G. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.12.012 · Cited by 15
Reducing Intake of Sugar-Sweetened Beverages Is Vital to Improving Our Nation’s Health
Johnson, R. K. (2016) · Circulation · doi:10.1161/circulationaha.115.020453 · Cited by 14
The impact of non-caloric artificial sweetener aspartame on female reproductive system in mice model
Naik, A. Q., Zafar, T., & Shrivastava, V. K. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01115-4 · Cited by 15
Dietary Sugar Intake and Risk of Noncommunicable Diseases
Mojto, V., Singh, R. B., Gvozdjáková, A., Mojtová, M., Kucharská, J., Jaglan, P., Vančová, O., & Takahashi, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813148-0.00017-7 · Cited by 13
Vilma Quitral, R., Arteaga, J., Rivera, M., Galleguillos, J., & Valdés, I. (2019) · Revista chilena de nutrición · doi:10.4067/s0717-75182019000300245 · Cited by 13
Durán‐Agüero, S., Batten, E. B., María del Pilar Rodríguez, N., Arrivillaga, K. R. C., de Ariza, J. S., Cornwall, J. R., Bujaico, M. D. P. C., Alzamora, S., Espinoza-Bernardo, S. L., & Vega, C. E. (2015) · Revista médica de Chile · doi:10.4067/s0034-98872015000300012 · Cited by 13
Glu–Phe from onion (Allium Cepa L.) attenuates lipogenesis in hepatocytes
Lee, Y. G., Cho, J., Hwang, E. J., Jeon, T., & Moon, J. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1303358 · Cited by 13
Movahedian, M., Golzan, S. A., Asbaghi, O., Prabahar, K., & Hekmatdoost, A. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2233615 · Cited by 14
Combating Excessive Eating: A Role for Four Evidence‐Based Remedies
Rogers, P. J. (2018) · Obesity · doi:10.1002/oby.22280 · Cited by 15
Guru, S. K., Li, Y., Savinova, O. V., & Zhang, Y. (2022) · PeerJ · doi:10.7717/peerj.13071 · Cited by 12
Health Implications Associated with Aspartame Consumption: A Substantial Review
Naik, A. Q., Zafar, T., & Shrivastav, V. K. (2018) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2018.127.134 · Cited by 12
Higgins, K., Rawal, R., Kramer, M., Baer, D. J., Yerke, A. M., & Klurfeld, D. M. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100239 · Cited by 12
Effects of artificial and natural sweeteners on host metabolic health: A double-edged sword
Xue, H., Kang, X., Hong, K., Gao, Y., Tang, Y., Lin, Y., Liu, X., Huang, W., Zhan, J., & You, Y. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117158 · Cited by 14
Do low-calorie sweeteners promote weight gain in rodents?
Glendinning, J. I. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.043 · Cited by 11
Higgins, K., Rawal, R., Baer, D. J., O’Connor, L. E., & Appleton, K. M. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac090 · Cited by 11
Evert, A. B., & Riddell, M. C. (2014) · Medical Clinics of North America · doi:10.1016/j.mcna.2014.09.001 · Cited by 16
Sylvetsky, A. C., Hiedacavage, A., Shah, N., Pokorney, P. E., Baldauf, S., Merrigan, K., Smith, V., Long, M. W., Black, R., Robien, K., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.334 · Cited by 10
Sánchez‐Delgado, M., Estrada, J. A., Cervantes, V. P., Kaufer‐Horwitz, M., & Contreras, I. (2019) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000611 · Cited by 13
Impacto del uso de edulcorantes no calóricos en la salud cardiometabólica
Manzur, F., Morales-Núñez, M. A., Ordosgoitia-Morales, J., Quiroz-Mendoza, R., Ramos-Villegas, Y., & Corrales-Santander, H. R. (2020) · Revista Colombiana de Cardiología · doi:10.1016/j.rccar.2019.11.003 · Cited by 11
Acero, D., Zoellner, J., Davy, B. M., & Hedrick, V. E. (2020) · Nutrients · doi:10.3390/nu12113428 · Cited by 10
Singh, A. K., Singh, A., Singh, R., Joshi, S., & Misra, A. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102829 · Cited by 10
Low-Calorie Sweeteners in Foods, Beverages, and Food and Beverage Additions: NHANES 2007–2012
DellaValle, D. M., Malek, A. M., Hunt, K. J., Peter, J. V. S., Greenberg, D., & Marriott, B. P. (2018) · Current Developments in Nutrition · doi:10.1093/cdn/nzy024 · Cited by 10
Metabolic Effects of Low‐Calorie Sweeteners: A Brief Review
Sylvetsky, A. C. (2018) · Obesity · doi:10.1002/oby.22252 · Cited by 11
Stadelmaier, J., Beyerbach, J., Roux, I., Harms, L., Eble, J., Nikolakopoulou, A., & Schwingshackl, L. (2024) · European Journal of Epidemiology · doi:10.1007/s10654-023-01058-5 · Cited by 9
Chatelan, A., Raeisi‐Dehkordi, H., & Salehi‐Abargouei, A. (2024) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2024.102105 · Cited by 10
Larsen, B. A., Litt, M. D., Huedo-Medina, T. B., & Duffy, V. B. (2019) · Nutrients · doi:10.3390/nu11020271 · Cited by 9
Li, H., Zhang, Y., He, Y., Huang, J., Yao, J., & Zhuang, X. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523001484 · Cited by 10
A Clinician’s Guide for Trending Cardiovascular Nutritional Controversies in 2026
Miller, M., Aggarwal, M., Allen, K., Bhattacharya, R., Dastmalchi, L. N., Kris‐Etherton, P. M., Klodas, E., Mozaffarian, D., Ostfeld, R. J., Petersen, K. S., et al. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.102591 · Cited by 9
Buso, M. E. C., Brouwer-Brolsma, E. M., Naomi, N. D., Harrold, J. A., Halford, J. C. G., Raben, A., & Feskens, E. J. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.889042 · Cited by 8
Individual differences in saccharin acceptance predict rats' food intake
Boakes, R. A., Martire, S. I., Rooney, K. B., & Kendig, M. D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.050 · Cited by 8
Non-caloric sweeteners and body weight.
Cavagnari, B. M. (2019) · Americanae (AECID Library) · Cited by 8
Question about a recent meta-analysis of low-calorie sweeteners and body weight
Pan, A., & Hu, F. B. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.098772 · Cited by 8
Potential Effects of Low-Calorie Sweeteners on Human Health
Chen, H.-P., Kao, Y., Lin, M., Lee, C., Wu, H., & Kuo, H. (2025) · Nutrients · doi:10.3390/nu17172726 · Cited by 7
Impact of Artificial Sweeteners on Inflammation Markers: A Systematic Review of Animal Studies
Raoul, P. C., Romano, M., Galli, F. S., Cintoni, M., Capristo, E., Mora, V., Mele, M. C., Gasbarrini, A., & Rinninella, E. (2025) · Nutrients · doi:10.3390/nu17203251 · Cited by 7
Buso, M. E. C., Brouwer-Brolsma, E. M., Naomi, N. D., Ngo, J., Soedamah‐Muthu, S. S., Mavrogianni, C., Harrold, J. A., Halford, J. C. G., Raben, A., Geleijnse, J. M., et al. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03192-y · Cited by 8
Zhang, J., Yan, L., Li, F., He, M., Li, J., Zhang, S., Zhao, W., Tang, Y., Li, Y., Xiong, J., et al. (2024) · Pediatric Obesity · doi:10.1111/ijpo.13096 · Cited by 6
The Bittersweet Reality: The Cardiovascular Risk of Artificial Sweeteners
Yeterian, M., Parikh, M. A., Frishman, W. H., & Peterson, S. J. (2024) · Cardiology in Review · doi:10.1097/crd.0000000000000748 · Cited by 7
Sweeteners: Regulatory Aspects
García‐Almeida, J. M., Cornejo-Pareja, I. M., Muñoz‐Garach, A., Gómez‐Pérez, A. M., & Garcı́a-Alemán, J. (2018) · Reference series in phytochemistry · doi:10.1007/978-3-319-27027-2_12 · Cited by 7
Martínez‐Magaña, J. J., Mendoza, A. D. G., Gallegos-Silva, I., López‐Narváez, M. L., Juárez‐Rojop, I. E., Díaz-Zagoya, J. C., Tovilla‐Zárate, C. A., González‐Castro, T. B., Nicolini, H., & Solis-Medina, A. (2024) · Nutrients · doi:10.3390/nu16040490 · Cited by 7
Jing, Y., Han, T. S., Alkhalaf, M. M., & Lean, M. E. J. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1716-z · Cited by 7
Hogenkamp, P. S. (2017) · Wiley eBooks · doi:10.1002/9781119044970.ch4 · Cited by 7
Antasouras, G., Dakanalis, A., Chrysafi, M., Papadopoulou, S. Κ., Trifonidi, I., Spanoudaki, M., Alexatou, O., Pritsa, A. A., Louka, A., & Giaginis, C. (2024) · Medical Sciences · doi:10.3390/medsci12020029 · Cited by 6
Stadelmaier, J., Bantle, G., Gorenflo, L., Kiesswetter, E., Nikolakopoulou, A., & Schwingshackl, L. (2025) · BMC Medicine · doi:10.1186/s12916-025-03860-2 · Cited by 6
Kołodziejczyk, A., & Nowak, J. (2025) · Nutrients · doi:10.3390/nu17111899 · Cited by 6
The association of artificial sweeteners intake and risk of cancer: an umbrella meta-analysis
Abu‐Zaid, A., Kutbi, E., Alshammari, N., AlJurayyan, A. N., Adly, H. M., Saleh, S. A. K., Baradwan, S., Jamal, M., Peer-Zada, F., Mohamed, S., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1647178 · Cited by 6
Metadata
- Authors
- Miller, P. E., & Perez, V.
- ORCID
- Miller, Paige E
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 100
- Issue
- 3
- Pages
- 765-777
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC4135487
- OpenAlex
- W1963564461
- Cited by
- 313
- References
- 61
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 21 · 2023: 23 · 2022: 21 · 2021: 20 · 2020: 34 · 2019: 31 · 2018: 40 · 2017: 30 · 2016: 32 · 2015: 24 · 2014: 7
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- artificial sweeteners, body weight, body composition, body mass index, fat mass, waist circumference, weight loss, weight maintenance, energy intake
- MeSH terms
- Energy Intake, Diet, Reducing, Humans, Patient Compliance, Prospective Studies, Recurrence, Reproducibility of Results, Cohort Studies, Weight Loss, Body Mass Index, Randomized Controlled Trials as Topic, Evidence-Based Medicine, Adiposity, Overweight, Non-Nutritive Sweeteners, Nutritive Sweeteners
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