Relation between human vasopressin 1a gene variance, fat intake, and diabetes
Open accessAbstract
Background Male arginine vasopressin 1a receptor knockout mice (V1aR(-/-)) display a phenotype of low triglycerides and high glucose concentrations and high-fat-diet-induced obesity and diabetes. Objective We investigated whether genetic variation of the human arginine vasopressin 1A (AVPR1A) gene is associated with phenotypic features resembling those of the V1aR(-/-) mouse. Design In a population-based cross-sectional study in southern Sweden, middle-aged individuals (n = 6,055) were examined in 1991-1994. Associations between 4 AVPR1A tag single nucleotide polymorphisms (rs1042615, rs10784339, rs7308855, and rs10747983) and diabetes status, glucose and triglyceride concentrations, and BMI were analyzed. Furthermore, rs1042615 was related to diabetes status, glucose, and triglycerides within sex-specific quartiles of dietary fat intake (Q1(Fat)-Q4(Fat)) and BMI (Q1(BMI)-Q4(BMI)). Results Subjects carrying the T allele of rs1042615 had lower concentrations of triglycerides than did CC carriers (1.36 +/- 0.77 compared with 1.42 +/- 0.89 mmol/L; P = 0.014), especially in nondiabetic subjects (P = 0.001). Carriers of the rs1042615 T allele had higher fasting blood glucose (5.20 +/- 1.44 mmol/L compared with 5.12 +/- 1.22 mmol/L; P = 0.036) and a tendency toward an increased prevalence of diabetes (odds ratio: 1.22; 95% CI: 0.99, 1.51; P = 0.067) compared with CC carriers. The less common rs10784339, rs7308855, and rs10747983 were not consistently associated with metabolic varia…
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In a large population sample, a frequent variant of the human AVPR1A gene is linked to disturbed glucose homeostasis.
“This experimental observation is in line with the association reported between a common genetic variant in the human AVPR1A gene and impaired glucose homeostasis in a large population-based sample [33].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [33]
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Self-citation
- Authors
- Enhörning, S., Leosdottir, M., Wallström, P., Gullberg, B., Berglund, G., Wirfält, E., & Melander, O.
- Affiliations
- Lund University (SE)
- Corresponding author
- Enhörning, Sofia
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 89
- Issue
- 1
- Pages
- 400-406
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2007724949
- Cited by
- 55
- References
- 17
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- genetic polymorphism, dietary fat intake, diabetes mellitus, triglycerides, fasting blood glucose, body mass index, obesity, type 2 diabetes risk, sex differences, genetic susceptibility to diabetes, middle-aged adults, Swedish population
- MeSH terms
- Alleles, Animals, Arginine, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Dietary Fats, Female, Humans, Male, Middle Aged, Obesity, Prospective Studies, Triglycerides, Genetic Variation, Hypertriglyceridemia, Cohort Studies, Body Mass Index, Prevalence, Receptors, Vasopressin, Mice, Knockout, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Mice
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