The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation
Open accessAbstract
Constipation is a common and burdensome gastrointestinal disorder that may result from altered gastrointestinal motility. The effect of probiotics on constipation has been increasingly investigated in both animal and human studies, showing promising results. However, there is still uncertainty regarding the mechanisms of action of probiotics on gut motility and constipation. Several factors are vital to normal gut motility, including immune and nervous system function, bile acid metabolism and mucus secretion, and the gastrointestinal microbiota and fermentation; an imbalance or dysfunction in any of these components may contribute to aberrant gut motility and, consequently, symptoms of constipation. For example, adults with functional constipation have significantly decreased numbers of bifidobacteria (with one study showing a mean difference of 1 log 10/g) and lactobacilli (mean difference, 1.4 log 10/g) in stool samples, as well as higher breath methane, compared with control subjects. Modifying the gut luminal environment with certain probiotic strains may affect motility and secretion in the gut and, hence, provide a benefit for patients with constipation. Therefore, this review explores the mechanisms through which probiotics may exert an effect on gut motility and constipation. Nevertheless, the majority of current evidence is derived from animal studies, and therefore, further human studies are needed to determine the mechanisms through specific probiotic strains that might be effective in constipation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Gut microbiota, which comprises a complex community of micro-organisms inhabiting the gastrointestinal tract, including bacteria, viruses, fungi and other micro-organisms, plays a crucial role in gut motility.6”
In the citing paper
“Patients with chronic constipation often exhibit increased proliferation of T cells and lymphocytes such as CD4 + T cells and CD8 + T cells, indicating the activation of T cellmediated cellular immunity.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
In the citing paper
“Inf lammation-induced adherence and immune responses by CD8 + T cells on intestinal neurons can lead to acute neuronal injury, colorectal dilation, and slowed colonic water transport, which can result in the development or worsening of constipation symptoms [27].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
In the citing paper
“In addition, substance P (SP) stored in visceral neurons stimulates smooth muscle contraction and amplifies visceral pain; when constipation occurs in central nervous system disorders, nerves containing SP are stimulated, leading to the release of stored SP and resulting in abdominal pain [8,22,27].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
In the citing paper
“The production of endogenous substances by the intestinal microbiota can also affect intestinal motility [27,31,38].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 1×
“The gastrointestinal microbiota plays a crucial role in the normal development of the CNS (23) and seems to interact with both the CNS and gut (24) through microbiota–enterochromaffin cells–vagal afferent nerve signaling (25).”
Background
Research works printed but not linked: 1
- Farmer, 1982, The effect of betamethasone on altered responsiveness of isolated intestine from rats infected with Nippostrongylus brasiliensis (abstr), Br J Pharmacol, 76, 192P
Cited by
Sorted by citations
Items 201–300 of 473
Tryptophan Metabolism in Postmenopausal Women with Functional Constipation
Błońska, A., Chojnacki, M., Macieja, A., Błasiak, J., Majsterek, I., Chojnacki, J., & Popławski, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010273 · Cited by 14
Human milk oligosaccharides: bridging the gap in intestinal microbiota between mothers and infants
Sun, W. C., Tao, L., Qian, C., Xue, P., Du, S.-S., & Tao, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1386421 · Cited by 16
Shin, M., Ban, O., Jung, Y. H., Yang, J., & Kim, Y. (2021) · Letters in Applied Microbiology · doi:10.1111/lam.13449 · Cited by 13
Zhang, Y.-X., Wang, H.-X., Li, Q.-X., Chen, A.-X., Wang, X., Zhou, S., Xie, S.-T., Li, H., Wang, J., Zhang, Q., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113344 · Cited by 14
Gan, D., Chen, J., Tang, X., Xiao, L., Martoni, C., Leyer, G. J., Huang, G., & Li, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.985308 · Cited by 17
Medications for constipation in 2020
Medina-Centeno, R. (2020) · Current opinion in pediatrics · doi:10.1097/mop.0000000000000938 · Cited by 10
Preventive effect of kiwi berry ( Actinidia arguta ) on loperamide-induced constipation
Zhang, J., Li, B., Gao, N., Li, H., Cui, X., Jiang, H., Tang, S., Jin, C., & Tian, J. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250119 · Cited by 12
Kong, X., Zhao, J. W., Gao, H., Wang, W., Wang, J., & Tan, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103808 · Cited by 12
Silva, A. T. D. A., Cavalcanti, I. D. L., Fernandes, M. A. D. L., Coimbra, C. G. D. O., & Lima, G. M. D. S. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.04.002 · Cited by 12
Alyousif, Z., Miller, J. L., Auger, J., Sandoval, M., Piano, A., Tompkins, T. A., & Dahl, W. J. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1535 · Cited by 11
“Probiotics have been suggested as a potential therapeutic agent for alleviating symptoms of constipation through regulating motility, although specific mechanisms remain unclear (Dimidi et al., 2017).”
BackgroundEkwudo, M. N., Masson, B. A., Natale, M. R. D., Kiridena, P., van de Garde, N., Lei, E., Sarkar, S. K., Narayana, V. K., Renoir, T., Furness, J. B., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106074 · Cited by 11
Deng, M., Ye, J., Zhang, R., Zhang, S., Dong, L., Su, D., Zhang, M., & Huang, F. (2024) · Food & Function · doi:10.1039/d4fo02765e · Cited by 11
Luk-in, S., Leepiyasakulchai, C., Saelee, C., Keeratichamroen, A., Srisangwan, N., Ponprachanuvut, P., Chammari, K., Chatsuwan, T., Wannigama, D. L., Shein, A. M. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-79465-1 · Cited by 11
Maltodextrin alleviates constipation induced by loperamide hydrochloride in mice
Zhen, Y., Chen, Q., Ren, Y., Shi, J., Xu, Z., Xue, Y., & Geng, Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105675 · Cited by 11
Drago, L., Meroni, G., Chiaretti, A., Laforgia, N., Cucchiara, S., Baldassarre, M. E., & on behalf of the Surveyflor Group (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103080 · Cited by 12
Blending Three Probiotics Alleviates Loperamide-Induced Constipation in Sprague-Dawley (SD)-Rats
Jang, Y.-J., Moon, J. S., Kim, J. E., Kim, D., Choi, H. S., & Oh, I. (2023) · Food Science of Animal Resources · doi:10.5851/kosfa.2023.e61 · Cited by 10
Wemelle, E., Carneiro, L., Abot, A., Lésage, J., Cani, P. D., & Knauf, C. (2022) · Nutrients · doi:10.3390/nu14102176 · Cited by 10
Wu, P.-N., Xiong, S., Zhong, P., Yang, W., Chen, M., & Tang, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.956204 · Cited by 13
Tierney, B. T., Versalovic, J. A., Fasano, A., Petrosino, J. F., Chumpitazi, B. P., Mayer, E. A., Boetes, J., Smits, G., Parkar, S. G., Voreades, N., et al. (2022) · Pediatric Research · doi:10.1038/s41390-022-02289-0 · Cited by 10
Luo, M., Xiong, L., Zhang, L., & Xu, Q. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-02884-3 · Cited by 13
Fukuoka, H., Toyama, H., Mizumoto, T., Ishida, J., Asari, S., Goto, T., Nanno, Y., Urade, T., Fukushima, K., Gon, H., et al. (2023) · World Journal of Surgery · doi:10.1007/s00268-023-07104-3 · Cited by 9
Liu, Q., Ke, D., Chen, Y., Shen, A., Liu, L., Hu, L., Ren, Y., Fang, W., Zhao, P., Sferraf, T. J., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1337078 · Cited by 12
Gut Microbiota and Metabolite Profiles Associated With Functional Constipation Severity
Wang, J., He, J., Liu, D., Zhang, T., Wu, Y., & Xie, M. (2024) · Microbiology and Immunology · doi:10.1111/1348-0421.13187 · Cited by 10
Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance
Zhu, L., & Yang, X. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s504616 · Cited by 9
Poly-γ-glutamic acid alleviates slow transit constipation by regulating aquaporin and gut microbes
Wang, X., Zhou, J., Sun, Z., Jia, R., Huang, D., Tang, D., Xia, T., & Xiao, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-92783-2 · Cited by 10
Qiao, L., Wang, L.-J., Wang, Y., Chen, Y., Zhang, H., & Zhang, S. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000345 · Cited by 9
Li, Y., Yu, Y., Wu, X., Liu, B., Ma, H., Zhao, X., Cao, S., Ding, S., Li, T., Wang, X., et al. (2022) · Nutrition · doi:10.1016/j.nut.2022.111802 · Cited by 10
Zhao, T., Lu, J., Qin, J., Chen, Y., Shi, Z., Wei, W., Xiong, P., Ma, D., & Song, X. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1117028 · Cited by 10
Probiotics for functional constipation in children: an overview of overlapping systematic reviews
Zhang, Y., Li, A., Qiu, J., Wen, H., Zhang, H., & Sun, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1323521 · Cited by 11
Chojnacki, C. J., Mędrek-Socha, M., Błońska, A., Błasiak, J., Popławski, T., Chojnacki, J., & Gąsiorowska, A. (2024) · Nutrients · doi:10.3390/nu16071027 · Cited by 9
Minas Frescal Cheese as a Probiotic Carrier
Pimentel, T. C., Marcolino, V. A., Barão, C. E., Klososki, S. J., & Rosset, M. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-54528-8_66-1 · Cited by 9
Cecal motility and the impact of Lactobacillus in feather pecking laying hens
van Staaveren, N., Krumma, J., Forsythe, P., Kjær, J. B., Kwon, I. Y., Mao, Y., West, C. L., Kunze, W., & Harlander-Matauschek, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69928-6 · Cited by 11
The influence of constipation on asthma: A real‐world, population‐based cohort study
Huang, Y., Wu, M., Wang, Y., & Wei, J. C. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14540 · Cited by 9
Bi, D., Jiang, H., Yang, K., Guan, T., Hou, L., & Shu, G. (2023) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2022.1089 · Cited by 8
Lora, A. T., Penadés, B. F., Oliva, S. L., Arponen, S., Okutan, G., Niño, G. M. S., & Martín, I. S. M. (2023) · Gastroenterology report · doi:10.1093/gastro/goae101 · Cited by 10
Fang, L., Yi, X., Shen, J., Deng, N., & Peng, X. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1539277 · Cited by 8
He, X., Zhang, Y., Fang, H., Ma, N., Yan, X., Yang, H., Cao, L., Xu, L., Hu, H., & Liu, H. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106841 · Cited by 9
Li, C., Wu, Y., Liang, H., Dong, Y., Fang, S., Jeong, P.-Y., Kim, H., & Gu, S. (2025) · Nutrients · doi:10.3390/nu17101729 · Cited by 9
Dimidi, E. (2025) · Proceedings of The Nutrition Society · doi:10.1017/s0029665125100694 · Cited by 10
Self-citationLee, Y.-F., Wu, M., Sheng‐Kai, K., Huang, J., & Wei, J. C. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1116239 · Cited by 8
Kafoury, B. M. E., Ebrahim, A. T., Hamid, M. S. A.-E., Mehanna, N. S., Ramadan, G. E.-S. I., & Morsy, W. E. (2023) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-230026 · Cited by 8
Xiao, H., Qin, Z., Xu, B., Long, M., Wu, Q., Guo, X., Zhang, H., Li, Z., & Wu, W. (2023) · Toxins · doi:10.3390/toxins16010014 · Cited by 8
Microbiota treatment of functional constipation: Current status and future prospects
Li, Y., Zhang, X., & Wang, Z.-K. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i5.776 · Cited by 10
Zhang, X., Jia, Y., Li, X., Wang, X., Li, L., Zhang, P., Dong, X., Ze, X., An, Y., & Li, J. (2017) · Beneficial Microbes · doi:10.1163/18762891-bja00039 · Cited by 8
Kaur, M., Aran, K. R., & Paswan, R. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06708-4 · Cited by 8
Słupecka‐Ziemilska, M., Grzesiak, P., Kowalczyk, P., Wychowański, P., & Woliński, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.693150 · Cited by 8
Белкина, Т. В., Averina, O. V., Savenkova, E. V., & Даниленко, В. Н. (2021) · Biology Bulletin Reviews · doi:10.1134/s2079086421040034 · Cited by 7
Managing constipation in children with ASD – A challenge worth tackling
Mulay, K. V., & Karthik, S. V. (2022) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2021.11.009 · Cited by 10
Layunta, E., Forcén, R., & Grasa, L. (2022) · Cells · doi:10.3390/cells11111791 · Cited by 8
Brunelli, L., Vitis, V. D., Ferrari, R., Minuzzo, M., Fiore, W., Jäger, R., Taverniti, V., & Guglielmetti, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.857987 · Cited by 11
Shen, X., Xu, Y., Yin, L., Cheng, J., Yin, D., Zhao, R., Dai, Y., Hu, X., Hou, H., Qian, K., et al. (2022) · Foods · doi:10.3390/foods12010079 · Cited by 8
Nagamine, T., & Nakamura, M. (2020) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2020-022 · Cited by 8
Wu, L.-Q., Yuan, Q., Wu, L., Xia, H. H., Zhong, M., Liu, T., Ye, X., Luo, D.-P., Xu, J., Xie, W.-R., et al. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-02929-7 · Cited by 7
Li, J., Zheng, H., Liu, J., Ding, J., Guo, Q., & Zhang, N. (2024) · Antioxidants · doi:10.3390/antiox14010014 · Cited by 9
Probiotics enhance vitamin absorption in the intestine: influencing factors and potential mechanisms
Hu, P., Tan, H., Xu, W., Liu, S., Song, J., Chen, X., & Suo, H. (2025) · Food & Function · doi:10.1039/d4fo04252b · Cited by 7
Modulation of Intestinal Smooth Muscle Cell Function by BL-99 Postbiotics in Functional Constipation
Zhao, W., Liu, M., Lan, H., Wang, R., Hung, W., He, J., & Fang, B. (2025) · Foods · doi:10.3390/foods14193441 · Cited by 7
Ren, Z., Zhao, A., Zhang, J., Yang, C., Zhong, W., Mao, S., Wang, S., Yuan, Q., Wang, P., & Zhang, Y. (2022) · Beneficial Microbes · doi:10.3920/bm2021.0132 · Cited by 7
Recombinant Probiotic Preparations: Current State, Development and Application Prospects
Khablenko, A., Danylenko, S., Yalovenko, O., Дуган, О. М., Potemska, O., & Prykhodko, D. (2023) · Innovative Biosystems and Bioengineering · doi:10.20535/ibb.2022.6.3-4.268349 · Cited by 8
Li, X., Wang, X., Wang, Z., & Guan, J. (2023) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12351 · Cited by 7
Qiu, Y., Yan, F., Yu, H., Li, H., Xia, S., Zhang, J., & Zhu, J. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114642 · Cited by 7
Probiotics in Functional Gastrointestinal Disorders
Hojsak, I. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_10 · Cited by 9
Salo, E., Roche, D., Gomez-Martinez, V. B., Cruz-Domenech, J. M., Garcia-Mora, L. G., Gabernet-Castello, C., & Freixenet, N. (2017) · Beneficial Microbes · doi:10.1163/18762891-bja00038 · Cited by 7
Ward, C., Perelman, D., Durand, L. R., Robinson, J. L., Cunanan, K. M., Sudakaran, S., Sabetan, R., Madrigal-Moeller, M. J., Dant, C. C., Sonnenburg, E. D., et al. (2025) · Contemporary Clinical Trials · doi:10.1016/j.cct.2025.107834 · Cited by 7
Arab, A., Karimi, E., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220415114343 · Cited by 7
The Management of Recurrent Urinary Tract Infection: Non-Antibiotic Bundle Treatment
Venturini, S., Reffo, I., Avolio, M., Basaglia, G., Fabro, G. D., Callegari, A., Tonizzo, M., Sabena, A., Rondinella, S., Mancini, W., et al. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10141-y · Cited by 7
Li, Z., Guo, Q., Lin, F., Li, C., Yan, L., Zhou, H., Huang, Y., Lin, B., Xie, B., Lin, Z., et al. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103216 · Cited by 7
Li, M., Zhang, Q., Zhao, W., Chen, J., Liu, Y., Zhou, L., Liu, Y., Wang, L., Guan, Y., He, J., et al. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100598 · Cited by 6
Huang, X., Youguang, X., Kai, H., Wei-wei, Q., Qing, L., Qing, Z., & Jingbo, X. (2023) · PubMed Central · doi:10.19852/j.cnki.jtcm.2023.06.008 · Cited by 6
Chen, K., Zhou, Z., Nie, Y., Cao, Y., Yang, P., Zhang, Y., Xu, P., Yu, Q., Shen, Y., Ma, W., et al. (2024) · Brazilian Journal of Microbiology · doi:10.1007/s42770-024-01276-3 · Cited by 12
Hu, X., Feng, J., Lü, J., Pang, R., Zhang, A., Liu, J., Gou, X., Bai, X., Wang, J., Chang, C., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1395671 · Cited by 8
Tian, R., Wang, W., Bai, Y., Tang, Y., Zhang, Q., & Yue, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1492047 · Cited by 6
Tarantino, G., Cataldi, M., & Citro, V. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1319897 · Cited by 7
Development of technical regulations for the capsulated probiotic manufacture
Paliy, А., Gujvinska, S. O., & Kalashnyk, M. V. (2020) · Ukrainian Journal of Ecology · doi:10.15421/2020_226 · Cited by 6
The effect of sodium carboxymethyl starch with high degree of substitution on defecation
Lu, W.-D., Wu, M., Zhang, J., Huang, T., Du, S., & Cao, Y.-X. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257012 · Cited by 7
Yasuda, R., Kamada, K., Murakami, T., Inoüe, R., Mizushima, K., Hirose, R., Inoue, K., Dohi, O., Yoshida, N., Katada, K., et al. (2022) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000756 · Cited by 6
Haghighi, D., Yazdani, S., Farzanehpour, M., & Gouvarchinghaleh, H. E. (2022) · Infectious Agents and Cancer · doi:10.1186/s13027-022-00464-w · Cited by 6
Zhao, Y., Zhang, C., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2022) · Food & Function · doi:10.1039/d2fo02675a · Cited by 6
Liu, Y., Ye, F., & Ma, L. (2024) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.40.4.8514 · Cited by 6
Zhang, J., Li, D., Tian, Q., Ding, Y., Jiang, H., Xin, G., Cheng, S., Tang, S., Jin, C., Tian, J., et al. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0001 · Cited by 6
Huang, R., Zhang, B.-B., Wang, J., Zhao, W., Huang, Y., Liu, Y. M., Sun, L., & Deng, Z. (2024) · Animals · doi:10.3390/ani14172523 · Cited by 5
Liang, X., Wan, D., Li, X.-L., Peng, Y., & Chen, L. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1524327 · Cited by 5
Microbiota—A Rescuing Modulator in Children Struggling with Functional Constipation
Tomsa, N., Meliţ, L. E., Popescu, T., Najjar, K., Văsieșiu, A.-M., Pop, A. V., & Balas, R. B. (2025) · Microorganisms · doi:10.3390/microorganisms13071504 · Cited by 6
Dudun, A. A., Chesnokova, D. V., Voinova, V. V., Bonartsev, A. P., & Bonartseva, G. A. (2023) · Polymers · doi:10.3390/polym15173649 · Cited by 6
Fu, H., Fan, D., Wang, J., Kou, R., Wang, Y., Wu, Y., & Wang, S. (2024) · Food Quality and Safety · doi:10.1093/fqsafe/fyae043 · Cited by 6
Wang, L.-S., Wu, J.-X., Zhang, F., Huang, Y., Jiang, Y.-X., & Li, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1455824 · Cited by 5
Zhang, J., & Zhang, P.-F. (2024) · Medicine · doi:10.1097/md.0000000000040137 · Cited by 6
Jang, J. H., Chang, Y. B., Kim, S. M., Han, K., Sim, W., Hong, K., Suh, H. J., & Han, S. (2024) · Food & Function · doi:10.1039/d4fo04237a · Cited by 6
Sun, Z., Su, X., Zhao, X., Yao, Y., Zhao, Y., Zhang, P., Li, Z., & Fu, S. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12432 · Cited by 5
Stimulatory Effect of Lactobacillus Metabolites on Colonic Contractions in Newborn Rats
Sobol, C. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010662 · Cited by 5
Constipation anti-aging effects by dairy-based lactic acid bacteria
Jaafar, M. H., Xu, P., Mageswary, M. U., Balasubramaniam, S.-D., Solayappan, M., Woon, J. J., Teh, C. S. J., Todorov, S. D., Park, Y.-H., Liu, G., et al. (2023) · Journal of Animal Science and Technology · doi:10.5187/jast.2023.e93 · Cited by 5
Pierro, F. D., Zerbinati, N., Cazzaniga, M., Bertuccioli, A., Palazzi, C. M., Cavecchia, I., Matera, M., Labrini, E., Sagheddu, V., & Soldi, S. (2024) · Microorganisms · doi:10.3390/microorganisms12081626 · Cited by 5
Lu, W. F., Liu, L., Zhang, Y. H., & Liu, H. (2024) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002060 · Cited by 5
The Potential of Polysaccharides from Various Plants as Constipation Treatment
Sari, Y. P., & Candraruna, D. B. (2023) · Journal of Applied Food Technology · doi:10.17728/jaft.20621 · Cited by 5
The impact of carbohydrate quality on gut health: Insights from the NHANES
Hu, L., Huang, X., Liu, S., Fang, L., Zhang, J., & Tang, X. (2025) · PLoS ONE · doi:10.1371/journal.pone.0315795 · Cited by 4
Wang, N., Wu, P., & Chen, X. D. (2025) · Foods · doi:10.3390/foods14081335 · Cited by 4
Niu, L., Duan, H., Wang, J., Jia, Z., Li, H., Guo, J., Zhang, S., Liu, N., Miao, Y., Ge, J., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1606626 · Cited by 4
Wang, C., Zhang, Q., Wei, C., & Jin, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149010 · Cited by 4
Naranjani, B., Hossain, S., Tjakra, M., Azhand, P., Bergström, C. A. S., Sinko, P. D., & Larsson, P. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2607779 · Cited by 4
Yang, F., Wang, G., Huang, M., Liu, X., Tang, S., Li, W., Luo, Y., Bai, J., & Huang, L. (2026) · Foods · doi:10.3390/foods15020240 · Cited by 4
Cheng, S., Cui, H., Zhang, J., Wang, Q., & Duan, Z. (2024) · Scientific Reports · doi:10.1038/s41598-024-51497-7 · Cited by 5
Metadata
- Authors
- Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K.
- Affiliations
- Queen Mary University of London (GB)
- King's College London (GB)
- Corresponding author
- Whelan, Kevin
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 8
- Issue
- 3
- Pages
- 484-494
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC5421123
- OpenAlex
- W2615801135
- Cited by
- 468
- References
- 108
- Citations by year
- 2026: 36 · 2025: 68 · 2024: 90 · 2023: 70 · 2022: 73 · 2021: 52 · 2020: 39 · 2019: 23 · 2018: 14 · 2017: 3
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, constipation, intestinal motility, gut microbiota, Bifidobacterium, lactobacilli, bile acid metabolism, mucus secretion, gut fermentation, breath methane, functional constipation, immune function, nervous system function
- MeSH terms
- Gastrointestinal Microbiome, Animals, Constipation, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Probiotics, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
