The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation
Open accessAbstract
Constipation is a common and burdensome gastrointestinal disorder that may result from altered gastrointestinal motility. The effect of probiotics on constipation has been increasingly investigated in both animal and human studies, showing promising results. However, there is still uncertainty regarding the mechanisms of action of probiotics on gut motility and constipation. Several factors are vital to normal gut motility, including immune and nervous system function, bile acid metabolism and mucus secretion, and the gastrointestinal microbiota and fermentation; an imbalance or dysfunction in any of these components may contribute to aberrant gut motility and, consequently, symptoms of constipation. For example, adults with functional constipation have significantly decreased numbers of bifidobacteria (with one study showing a mean difference of 1 log 10/g) and lactobacilli (mean difference, 1.4 log 10/g) in stool samples, as well as higher breath methane, compared with control subjects. Modifying the gut luminal environment with certain probiotic strains may affect motility and secretion in the gut and, hence, provide a benefit for patients with constipation. Therefore, this review explores the mechanisms through which probiotics may exert an effect on gut motility and constipation. Nevertheless, the majority of current evidence is derived from animal studies, and therefore, further human studies are needed to determine the mechanisms through specific probiotic strains that might be effective in constipation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Gut microbiota, which comprises a complex community of micro-organisms inhabiting the gastrointestinal tract, including bacteria, viruses, fungi and other micro-organisms, plays a crucial role in gut motility.6”
In the citing paper
“Patients with chronic constipation often exhibit increased proliferation of T cells and lymphocytes such as CD4 + T cells and CD8 + T cells, indicating the activation of T cellmediated cellular immunity.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
In the citing paper
“Inf lammation-induced adherence and immune responses by CD8 + T cells on intestinal neurons can lead to acute neuronal injury, colorectal dilation, and slowed colonic water transport, which can result in the development or worsening of constipation symptoms [27].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
In the citing paper
“In addition, substance P (SP) stored in visceral neurons stimulates smooth muscle contraction and amplifies visceral pain; when constipation occurs in central nervous system disorders, nerves containing SP are stimulated, leading to the release of stored SP and resulting in abdominal pain [8,22,27].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
In the citing paper
“The production of endogenous substances by the intestinal microbiota can also affect intestinal motility [27,31,38].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 1×
“The gastrointestinal microbiota plays a crucial role in the normal development of the CNS (23) and seems to interact with both the CNS and gut (24) through microbiota–enterochromaffin cells–vagal afferent nerve signaling (25).”
Background
Flagged first, then by citations
Research works printed but not linked: 1
- Farmer, 1982, The effect of betamethasone on altered responsiveness of isolated intestine from rats infected with Nippostrongylus brasiliensis (abstr), Br J Pharmacol, 76, 192P
Cited by
Sorted by citations
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,143
Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview
Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102534 · Cited by 642
Advancing human gut microbiota research by considering gut transit time
Procházková, N., Falony, G., Dragsted, L. O., Licht, T. R., Raes, J., & Roager, H. M. (2022) · Gut · doi:10.1136/gutjnl-2022-328166 · Cited by 349
Probiotics in Medicine: A Long Debate
Stavropoulou, E., & Bezirtzoglou, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02192 · Cited by 312
Postbiotics in Human Health: A Narrative Review
Ma, L., Tu, H., & Chen, T. (2023) · Nutrients · doi:10.3390/nu15020291 · Cited by 259
Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study
Tan, A. H., Lim, S.-Y., Chong, K. K., A Manap, M. A. A., Hor, J. W., Lim, J. L., Low, S. C., Chong, C. W., Mahadeva, S., & Lang, A. E. (2021) · Neurology · doi:10.1212/wnl.0000000000010998 · Cited by 226
Blue poo: impact of gut transit time on the gut microbiome using a novel marker
Asnicar, F., Leeming, E. R., Dimidi, E., Mazidi, M., Franks, P. W., Khatib, H. A., Valdes, A. M., Davies, R., Bakker, E., Francis, L., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323877 · Cited by 208
Self-citationWernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 244
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health
Wan, Z., Zheng, J., Zhu, Z., Sang, L., Zhu, J., Luo, S., Zhao, Y., Wang, R., Zhang, Y., Hao, K., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1031502 · Cited by 213
Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases
Biazzo, M., & Deidda, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144119 · Cited by 172
Probiotics for Parkinson’s Disease
Gazerani, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174121 · Cited by 156
Cisplatin Mouse Models: Treatment, Toxicity and Translatability
Perše, M. (2021) · Biomedicines · doi:10.3390/biomedicines9101406 · Cited by 145
Horve, P. F., Lloyd, S., Mhuireach, G. Á., Dietz, L. G., Fretz, M., MacCrone, G., Wymelenberg, K. G. V. D., & Ishaq, S. L. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-019-0157-y · Cited by 133
Ballini, A., Santacroce, L., Cantore, S., Bottalico, L., Dipalma, G., Topi, S., Saini, R., Vito, D. D., & Inchingolo, F. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666181221150352 · Cited by 132
Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.005 · Cited by 131
Wang, L., Cen, S., Wang, G., Lee, Y. K., Zhao, J., Zhang, H., & Chen, W. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103953 · Cited by 123
Pesticide exposure and the microbiota-gut-brain axis
Matsuzaki, R., Gunnigle, E., Geissen, V., Clarke, G. A., Nagpal, J. K., & Cryan, J. F. (2023) · The ISME Journal · doi:10.1038/s41396-023-01450-9 · Cited by 129
Probiotic mechanisms of action
Halloran, K., & Underwood, M. A. (2019) · Early Human Development · doi:10.1016/j.earlhumdev.2019.05.010 · Cited by 123
Prebiotics and Probiotics for Gastrointestinal Disorders
Rau, S., Gregg, A., Yaceczko, S. D., & Limketkai, B. N. (2024) · Nutrients · doi:10.3390/nu16060778 · Cited by 127
Dixon, A., Robertson, K., Yung, A. E., Que, M. S., Randall, H., Wellalagodage, D., Cox, T., Robertson, D., Chi, C., & Sun, J. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01080-y · Cited by 118
Probiotics for constipation and gut microbiota in Parkinson's disease
Du, Y., Li, Y., Xu, X., Li, R., Zhang, M., Cui, Y., Zhang, L., Wei, Z. Z., Wang, S., & Tuo, H. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.08.022 · Cited by 103
Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation
Wang, J.-K., & Yao, S.-K. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/5560310 · Cited by 98
Rao, S. S. C., & Brenner, D. M. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001222 · Cited by 97
Effect of intrapartum antibiotics on the intestinal microbiota of infants: a systematic review
Zimmermann, P., & Curtis, N. C. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-316659 · Cited by 97
Microbial Colonization From the Fetus to Early Childhood—A Comprehensive Review
Senn, V., Bassler, D., Choudhury, R. A., Scholkmann, F., Righini‐Grunder, F., Vuille-dit-Bille, R. N., & Restin, T. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.573735 · Cited by 103
Wang, J., Liang, Q., Zhao, Q., Tang, Q., Ahmed, A. F., Zhang, Y., & Kang, W. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112305 · Cited by 96
Wegh, C. A. M., Baaleman, D. F., Tabbers, M. M., Smidt, H., & Benninga, M. A. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.09.010 · Cited by 104
Bajramagić, S., Hodžić, E., Mulabdić, A., Holjan, S., Vinčević-Smajlović, S., & Rovcanin, A. (2019) · Medical Archives · doi:10.5455/medarh.2019.73.316-320 · Cited by 94
Dimidi, E., Scott, S. M., & Whelan, K. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000934 · Cited by 90
Self-citationA key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation
Zhang, C., Yu, L., Ma, C., Jiang, S., Zhang, Y., Wang, S., Tian, F., Xue, Y., Zhao, J., Zhang, H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.10.011 · Cited by 98
Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review
Cheng, J., Laitila, A., & Ouwehand, A. C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.790561 · Cited by 93
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R., Dimidi, E., Fikree, A., Ford, A. C., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14050 · Cited by 97
Self-citationDimidi, E., Zdanaviciene, A., Christodoulides, S., Taheri, S., Louis, P., Duncan, P. I., Emami, N., Crabbé, R., De Castro, C. A., McLean, P., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15073 · Cited by 80
Self-citationAction Mode of Gut Motility, Fluid and Electrolyte Transport in Chronic Constipation
Zhao, Q., Chen, Y., Xu, D., Yue, S., Fu, R., Yang, J., Xing, L.-M., & Tang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.630249 · Cited by 87
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2022) · Kompass Nutrition & Dietetics · doi:10.1159/000523712 · Cited by 79
Leta, V., Chaudhuri, К. R., Milner, O., Chung‐Faye, G., Metta, V., Pariante, C. M., & Borsini, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.026 · Cited by 79
Yang, Z., Ye, S., Xu, Z., Su, H., Tian, X., Han, B. R., Shen, B., Liao, Q., Xie, Z., & Hong, Y. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110569 · Cited by 74
Takeda, T., Asaoka, D., Nojiri, S., Yanagisawa, N., Nishizaki, Y., Osada, T., Koido, S., Nagahara, A., Katsumata, N., Odamaki, T., et al. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002028 · Cited by 76
Saviano, A., Brigida, M., Migneco, A., Gunawardena, G., Zanza, C., Candelli, M., Franceschi, F., & Ojetti, V. (2021) · Medicina · doi:10.3390/medicina57070643 · Cited by 73
Wang, G., Yang, S., Sun, S., Si, Q., Wang, L., Zhang, Q., Wu, G., Zhao, J., Zhang, H., & Chen, W. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00423 · Cited by 75
Xu, Y., Shao, M., Fang, X., Tang, W., Zhou, C., Hu, X., Zhang, X., & Su, K. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.014 · Cited by 72
Chamberlain, C. A., Hatch, M., & Garrett, T. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222393 · Cited by 69
Chu, J. R., Kang, S.-Y., Kim, S.-E., Lee, S.-J., Lee, Y., & Sung, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i40.6129 · Cited by 72
Dysbiosis in Functional Bowel Disorders
Enck, P., & Mazurak, N. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000488773 · Cited by 73
Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice
Wang, L., Chai, M., Wang, J., Yu, Q., Wang, G., Zhang, H., Zhao, J., & Chen, W. (2022) · Food & Function · doi:10.1039/d1fo04151g · Cited by 69
Chronic Kidney Disease, Gut Dysbiosis, and Constipation: A Burdensome Triplet
Ikee, R., Sasaki, N., Yasuda, T., & Fukazawa, S. (2020) · Microorganisms · doi:10.3390/microorganisms8121862 · Cited by 65
Chen, C.-M., Wu, C.-C., Huang, C.-L., Chang, M.-Y., Cheng, S.-H., Lin, C.-T., & Tsai, Y.-C. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09814-3 · Cited by 67
Characterization of gut contractility and microbiota in patients with severe chronic constipation
Рашидовна, Я. Д., Ulfatovich, S. M., Андреевич, С. К., Arzamastseva, A. A., Shaidullov, I. F., Markelova, M., Grigoryeva, T. V., Karpukhin, O. Y., & Ситдикова, Г. Ф. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235985 · Cited by 62
Musthaq, S., Mazuy, A., & Jakus, J. R. (2018) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2018.03.012 · Cited by 64
The Interaction of Microbiome and Pancreas in Acute Pancreatitis
Zhang, C., Li, G., Lu, T., Liu, L., Sui, Y., Bai, R., Li, L., & Sun, B. (2023) · Biomolecules · doi:10.3390/biom14010059 · Cited by 61
Zhang, X., Zheng, J., Jiang, N., Sun, G., Bao, X., Kong, M., Cheng, X., Lin, A., & Liu, H. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105676 · Cited by 61
Gu, Y., Qin, X., Zhou, G., Wang, C., Mu, C., Liu, X., Zhong, W., Xu, X. J., Wang, B., Jiang, K., et al. (2022) · Food & Function · doi:10.1039/d2fo01900k · Cited by 61
Yak Milk: Nutritional Value, Functional Activity, and Current Applications
Wang, D., Zhou, Y., Zheng, X., Guo, J., Duan, H., Zhou, S., & Yan, W. (2023) · Foods · doi:10.3390/foods12112090 · Cited by 65
Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies
Zhu, Y., Mei, Q., Fu, Y., & Zeng, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111850 · Cited by 64
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
Yang, L., Wan, Y., Li, W., Liu, C., Li, H., Dong, Z., Zhu, K., Jiang, S., Shang, E., Qian, D., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11813-5 · Cited by 59
Araújo, M. M., & Botelho, P. B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.935830 · Cited by 58
Pre-, pro- and synbiotics in cancer prevention and treatment—a review of basic and clinical research
Scott, A. J., Merrifield, C. A., Younes, J. A., & Pekelharing, E. P. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.869 · Cited by 59
Xie, L., Chen, X., Fan, Y., Li, Y., Wang, Y., Zhang, X., Yu, S., Wang, J., Chai, R., Zhao, Z., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03152-2 · Cited by 57
Revisiting the intestinal microbiome and its role in Diarrhea and constipation
Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53
Kang, S., Park, M. Y., Brooks, I., Lee, J., Kim, S. H., Kim, J. Y., Oh, B., Kim, J. W., & Kwon, O. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110428 · Cited by 53
Fu, R., Li, Z., Zhou, R., Li, C., Shao, S., & Li, J. (2021) · Bioengineered · doi:10.1080/21655979.2021.1973356 · Cited by 53
Pediococcus acidilactici Strains Improve Constipation Symptoms and Regulate Intestinal Flora in Mice
Qiao, Y., Qiu, Z., Tian, F., Yu, L., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.655258 · Cited by 50
Probiotics in Functional Gastrointestinal Disorders
Hojsak, I. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_321 · Cited by 53
Probiotic-driven advancement: Exploring the intricacies of mineral absorption in the human body
Varvara, R.-A., & Vodnar, D. C. (2023) · Food Chemistry X · doi:10.1016/j.fochx.2023.101067 · Cited by 48
Šola, K. F., Vladimir‐Knežević, S., Hrabač, P., Mucalo, I., Saso, L., & Verbanac, D. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-022-01189-0 · Cited by 47
Taverniti, V., Cesari, V., Gargari, G., Rossi, U. G., Biddau, C., Lecchi, C., Fiore, W., Arioli, S., Toschi, I., & Guglielmetti, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.706135 · Cited by 48
The protective effects of yellow tea extract against loperamide-induced constipation in mice
Cao, P.-Q., Li, X., Ouyang, J., Jiang, R., Huang, F.-F., Wen, B., Zhang, X.-N., Huang, J., & Liu, Z. (2021) · Food & Function · doi:10.1039/d0fo02969f · Cited by 47
Probiotics in Irritable Bowel Syndrome: A Review of Their Therapeutic Role
Kumar, L. S., Pugalenthi, L. S., Ahmad, M., Reddy, S., Barkhane, Z., & Elmadi, J. (2022) · Cureus · doi:10.7759/cureus.24240 · Cited by 59
Microbial treatment: the potential application for Parkinson’s disease
Fang, X. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3641-6 · Cited by 45
Botelho, P. B., Ferreira, M. V. R., Araújo, A. D. M., Mendes, M. M., & Nakano, E. Y. (2020) · Nutrition · doi:10.1016/j.nut.2020.110890 · Cited by 47
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight
Angoa‐Pérez, M., & Kuhn, D. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000144 · Cited by 44
Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism
Wang, M., Cha, R., Hao, W., Du, R., Zhang, P., Hu, Y., & Jiang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c05809 · Cited by 43
Qu, L., Li, Y., Liu, F., Fang, Y., He, J., Ma, J., Xu, T., Wang, L., Lei, P., Dong, H., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0823-2 · Cited by 46
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04894-5 · Cited by 46
Cao, J., Wang, K., Li, N., Zhang, L., Qin, L., He, Y., Wang, J., Qu, C., & Miao, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.243 · Cited by 42
Zhao, X., Qian, Y., Li, G., Yi, R., Park, K., & Song, J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15206 · Cited by 44
Constipation in chronic kidney disease: it is time to reconsider
Ikee, R., Yano, K., & Tsuru, T. (2019) · Renal Replacement Therapy · doi:10.1186/s41100-019-0246-3 · Cited by 41
Zhang, C., Wang, L., Liu, X., Wang, G., Guo, X., Liu, X., Zhao, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15194230 · Cited by 42
Wegh, C. A. M., Benninga, M. A., & Tabbers, M. M. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001054 · Cited by 40
Effects of Probiotics and Prebiotics on Frailty and Ageing: A Narrative Review
Jayanama, K., & Theou, O. (2019) · Current Clinical Pharmacology · doi:10.2174/1574884714666191120124548 · Cited by 43
Probiotic Potential of Bacillus licheniformis and Bacillus pumilus Isolated from Tibetan Yaks, China
Zeng, Z., Zhang, J., Li, Y., Li, K., Gong, S., Li, F., Wang, P., Iqbal, M., Kulyar, M. F., & Li, J. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09939-z · Cited by 42
Qi, B., Zhang, Y., Ren, D., Qin, X., Wang, N., & Yang, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07709 · Cited by 39
Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials
Hong, C., Chen, J., & Huang, T. (2022) · Aging · doi:10.18632/aging.204266 · Cited by 41
Food supplements and diet as treatment options in irritable bowel syndrome
Dimidi, E., & Whelan, K. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13951 · Cited by 40
Self-citationFang, S., Wu, S., Ji, L., Fan, Y., Wang, X., & Yang, K. (2021) · Medicine · doi:10.1097/md.0000000000025390 · Cited by 40
Liu, L., Tian, F., Li, G.-Y., Xu, W., & Xia, R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1012087 · Cited by 40
Deidda, G., & Biazzo, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.753915 · Cited by 37
Effects of probiotics on loperamide-induced constipation in rats
Inatomi, T., & Honma, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02931-7 · Cited by 37
Efficacy and safety of probiotics in Parkinson’s constipation: A systematic review and meta-analysis
Xie, L., Chen, D., Xinghui, Z., & Cheng, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1007654 · Cited by 37
Characteristics of the Gut Microbiome and Serum Metabolome in Patients with Functional Constipation
Wang, J., Wang, L., Yu, Q., Tang, N., Mei, C., Zhang, H., Wang, G., Lu, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15071779 · Cited by 38
Araújo, M. M., Montalvão-Sousa, T. M., Teixeira, P. D. C., Figueiredo, A. C. M. G., & Botelho, P. B. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac069 · Cited by 40
Guo, Y., Song, L., Huang, Y., Li, X., Xiao, Y., Wang, Z., & Ren, Z. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1039403 · Cited by 40
Fruit Juices as Probiotic Foods
Pimentel, T. C., Klososki, S. J., Rosset, M., Barão, C. E., & Marcolino, V. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815851-7.00014-0 · Cited by 35
Jomehzadeh, N., Javaherizadeh, H., Amin, M., Rashno, M. M., & Teimoori, A. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s250755 · Cited by 35
Tang, T., Wang, J., Jiang, Y., Zhu, X., Zhang, Z., Wang, Y., Shu, X., Deng, Y., & Zhang, F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.890314 · Cited by 35
Probiotics alleviate constipation and inflammation in late gestating and lactating sows
Ma, T., Huang, W., Li, Y., Jin, H., Kwok, L., Sun, Z., & Zhang, H. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00434-z · Cited by 36
Zhang, J., Deji, C., Fan, J., Chang, L., Miao, X., Xiao, Y., Zhu, Y., & Li, S. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110058 · Cited by 34
Zhang, M., Zou, W., Xu, C., Jia, R., Liu, K., Xu, Q., & Xu, H. (2021) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002184 · Cited by 34
Yu, Z., Zhao, J., Qin, Y., Wang, Y., Zhang, Y., & Sun, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.850425 · Cited by 34
Chronic constipation and gut microbiota: current research insights and therapeutic implications
Xu, X., Wang, Y., Long, Y., & Cheng, Y. (2024) · Postgraduate Medical Journal · doi:10.1093/postmj/qgae112 · Cited by 32
Metadata
- Authors
- Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K.
- Affiliations
- Queen Mary University of London (GB)
- King's College London (GB)
- Corresponding author
- Whelan, Kevin
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 8
- Issue
- 3
- Pages
- 484-494
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC5421123
- OpenAlex
- W2615801135
- Cited by
- 468
- References
- 108
- Citations by year
- 2026: 36 · 2025: 68 · 2024: 90 · 2023: 70 · 2022: 73 · 2021: 52 · 2020: 39 · 2019: 23 · 2018: 14 · 2017: 3
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, constipation, intestinal motility, gut microbiota, Bifidobacterium, lactobacilli, bile acid metabolism, mucus secretion, gut fermentation, breath methane, functional constipation, immune function, nervous system function
- MeSH terms
- Gastrointestinal Microbiome, Animals, Constipation, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Probiotics, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
