Cited by 288Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

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Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats

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Jobgen, Wenjuan, Meininger, Cynthia J., Jobgen, Scott C., Li, Peng, Lee, Mi-Jeong, Smith, Stephen B., Spencer, Thomas E., Fried, Susan K., Wu, Guoyao·2009·The Journal of Nutrition

DOI 10.3945/jn.108.096362PMC PMC3151442

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Abstract

Previous studies showed that dietary L-arginine supplementation decreased white fat mass in genetically obese rats. This study tested the effectiveness of L-arginine in diet-induced obesity. Male Sprague-Dawley rats were fed for 15 wk a high-fat (HF) (40% energy) or low-fat (LF) (10% energy) diet beginning at 4 wk of age, resulting in 18% higher body weight gains and 74% higher weights of major white fat pads (retroperitoneal, epididymal, subcutaneous, and mesenteric adipose tissues) in HF than in LF fed rats. Starting at 19 wk of age, rats in each dietary group were supplemented for 12 wk with 1.51% L-arginine-HCl or 2.55% L-alanine (isonitrogenous control) (n = 8 per treatment) in drinking water and arginine groups were individually pair-fed to alanine controls. Despite similar energy intake, absolute weights of white fat pads increased by 98% in control rats over a 12-wk period but only by 35% in arginine-supplemented rats. The arginine treatment reduced the relative weights of white fat pads by 30% and enhanced those of soleus muscle by 13%, extensor digitorum longus muscle by 11%, and brown fat by 34% compared with control rats. Serum concentrations of insulin, adiponectin, growth hormone, corticosterone, triiodothyronine, and thyroxine did not differ between control and arginine-supplemented rats. However, arginine treatment resulted in lower serum concentrations of leptin, glucose, triglycerides, urea, glutamine, and branched-chain amino acids, higher serum concentrations of nitric-oxide metabolites, and improvement in glucose tolerance. Thus, dietary arginine supplementation shifts nutrient partitioning to promote muscle over fat gain and may provide a useful treatment for improving the metabolic profile and reducing body white fat in diet-induced obese rats.

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Authors: Jobgen, W., Meininger, C. J., Jobgen, S. C., Li, P., Lee, M.-J., Smith, S. B., Spencer, T. E., Fried, S. K., & Wu, G.
Affiliations: Texas A&M University (US)
University of Maryland, Baltimore (US)
Corresponding author: Wu, Guoyao
ORCID: Meininger, Cynthia J.
Lee, Mi-Jeong
Smith, Stephen B.
Spencer, Thomas E.
Fried, Susan K.
Wu, Guoyao
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2009-02
Volume: 139
Issue: 2
Pages: 230-237
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.108.096362
PMC: PMC3151442
OpenAlex: W2062237920
Cited by: 288
References: 42
Citations by year: 2026: 7 · 2025: 14 · 2024: 9 · 2023: 12 · 2022: 19 · 2021: 15 · 2020: 19 · 2019: 16 · 2018: 16 · 2017: 19 · 2016: 18 · 2015: 22 · 2014: 24 · 2013: 16 · 2012: 19
FWCI: 9.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5113 d)
Locations: Journal of Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
American Heart Association (#0755024Y)
Cooperative State Research, Education, and Extension Service
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072488)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: arginine supplementation, diet-induced obesity, white adipose tissue, brown adipose tissue, skeletal muscle mass, high-fat diet, nutrient partitioning, glucose tolerance, nitric oxide metabolites, leptin, branched-chain amino acids, glutamine, growth hormone, corticosterone, thyroxine, adiponectin, insulin
MeSH terms: Adipose Tissue, Amino Acids, Animals, Arginine, Blood Glucose, Body Weight, Adipose Tissue, Brown, Diet, Glucose Tolerance Test, Male, Nitric Oxide, Obesity, Organ Size, Rats, Sprague-Dawley, Muscle, Skeletal, Dietary Supplements, Leptin, Rats

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Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats

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