Cited by 388Neurotransmitter Receptor Influence on BehaviorEating Disorders and BehaviorsRegulation of Appetite and Obesity

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior

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Avena, Nicole M., Rada, Pedro, Hoebel, Bartley G.·2009·The Journal of Nutrition

Abstract

Ingestion of different nutrients, such as fats and sugars, normally produces different effects on physiology, the brain, and behavior. However, they do share certain neural pathways for reinforcement of behavior, including the mesolimbic dopamine (DA) system. When these nutrients are consumed in the form of binges, this can release excessive DA, which causes compensatory changes that are comparable to the effects of drugs of abuse. In this article, we review data obtained with animal models of fat and sugar bingeing. The concept of "food addiction" is described and reviewed from both clinical and laboratory animal perspectives. Behavioral manifestations of addictive-like behavior and concomitant alterations in DA and opioid systems are compared for sugar and fat bingeing. Finally, in relation to eating disorders and obesity, we discuss how fat may be the macronutrient that results in excess body weight, and sweet taste in the absence of fat may be largely responsible for producing addictive-like behaviors that include a withdrawal syndrome.

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Metadata

Authors
Avena, N. M., Rada, P., & Hoebel, B. G.
Affiliations
Princeton University (US)
Corresponding author
Hoebel, Bartley G.
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2009-03
Volume
139
Issue
3
Pages
623-628
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2138737041
Cited by
388
References
73
Citations by year
2026: 8 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 14 · 2021: 24 · 2020: 62 · 2019: 19 · 2018: 25 · 2017: 21 · 2016: 25 · 2015: 28 · 2014: 22 · 2013: 23 · 2012: 38
FWCI
13.36
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (AA12882)
  • National Institute on Alcohol Abuse and Alcoholism (AA12882, R01AA012882)
  • National Institute on Drug Abuse
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-79793, F32DK079793)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
food addiction, mesolimbic dopamine system, opioid system, eating disorders, obesity, sweet taste, withdrawal syndrome, macronutrients
MeSH terms
Animals, Bulimia, Dietary Carbohydrates, Dietary Fats, Humans, Rats

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