Cited by 313Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismNatural Antidiabetic Agents Studies

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Dietary Blueberry Attenuates Whole-Body Insulin Resistance in High Fat-Fed Mice by Reducing Adipocyte Death and Its Inflammatory Sequelae

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DeFuria, Jason, Bennett, Grace, Strissel, Katherine J., James, W. Perfield, Milbury, Paul E., Greenberg, Andrew S., Obin, Martin S.·2009·The Journal of Nutrition

DOI 10.3945/jn.109.105155PMC PMC2709302

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Abstract

Adipose tissue (AT) inflammation promotes insulin resistance (IR) and other obesity complications. AT inflammation and IR are associated with oxidative stress, adipocyte death, and the scavenging of dead adipocytes by proinflammatory CD11c+ AT macrophages (ATMPhi). We tested the hypothesis that supplementation of an obesitogenic (high-fat) diet with whole blueberry (BB) powder protects against AT inflammation and IR. Male C57Bl/6j mice were maintained for 8 wk on 1 of 3 diets: low-fat (10% of energy) diet (LFD), high-fat (60% of energy) diet (HFD) or the HFD containing 4% (wt:wt) whole BB powder (1:1 Vaccinium ashei and V. corymbosum) (HFD+B). BB supplementation (2.7% of total energy) did not affect HFD-associated alterations in energy intake, metabolic rate, body weight, or adiposity. We observed an emerging pattern of gene expression in AT of HFD mice indicating a shift toward global upregulation of inflammatory genes (tumor necrosis factor-alpha, interleukin-6, monocyte chemoattractant protein 1, inducible nitric oxide synthase), increased M1-polarized ATMPhi (CD11c+), and increased oxidative stress (reduced glutathione peroxidase 3). This shift was attenuated or nonexistent in HFD+B-fed mice. Furthermore, mice fed the HFD+B were protected from IR and hyperglycemia coincident with reductions in adipocyte death. Salutary effects of BB on adipocyte physiology and ATMPhi gene expression may reflect the ability of BB anthocyanins to alter mitogen-activated protein kinase and nuclear factor-kappaB stress signaling pathways, which regulate cell fate and inflammatory genes. These results suggest that cytoprotective and antiinflammatory actions of dietary BB can provide metabolic benefits to combat obesity-associated pathology.

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“Increased adipocyte death in obesity is suggested (8) to reflect the elevated levels of cytotoxic stressors reported for obese AT (10,11,22).”
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Authors: DeFuria, J., Bennett, G., Strissel, K. J., James, W. P., Milbury, P. E., Greenberg, A. S., & Obin, M. S.
Affiliations: Tufts University (US)
Corresponding author: James, W. Perfield
Greenberg, Andrew S.
Obin, Martin S.
ORCID: Bennett, Grace
Greenberg, Andrew S.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2009-08
Volume: 139
Issue: 8
Pages: 1510-1516
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.109.105155
PMC: PMC2709302
OpenAlex: W2171102147
Cited by: 313
References: 36
Citations by year: 2026: 5 · 2025: 8 · 2024: 14 · 2023: 8 · 2022: 12 · 2021: 27 · 2020: 15 · 2019: 22 · 2018: 19 · 2017: 23 · 2016: 19 · 2015: 22 · 2014: 24 · 2013: 33 · 2012: 16
FWCI: 13.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4930 d)
Locations: Journal of Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
U.S. Department of Agriculture
National Institutes of Health
National Heart, Lung, and Blood Institute (TH32HL69772, T32HL069772)
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK062032)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: blueberry, insulin resistance, adipose tissue inflammation, adipocyte death, high-fat diet, obesity, adipose tissue macrophages, oxidative stress, anthocyanins, M1 macrophage polarization, NF-κB signaling, MAPK signaling, hyperglycemia, dietary supplementation
MeSH terms: Animals, Anthocyanins, Anti-Inflammatory Agents, Diet, Dietary Fats, Fruit, Glutathione Peroxidase, Hyperglycemia, Insulin Resistance, Macrophages, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Gene Expression, Cell Death, Adipocytes, Chemokine CCL2, Plant Preparations, Blueberry Plants, Adiposity, Mice, Nitric Oxide Synthase Type II

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Dietary Blueberry Attenuates Whole-Body Insulin Resistance in High Fat-Fed Mice by Reducing Adipocyte Death and Its Inflammatory Sequelae

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