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Cited by 121Food composition and propertiesNutritional Studies and DietAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Whole and Refined Grain Intakes Are Related to Inflammatory Protein Concentrations in Human Plasma

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Masters, Rachel C., Liese, Angela D., Haffner, Steven M., Wagenknecht, Lynne E., Hanley, Anthony J.·2010·The Journal of Nutrition
DOI 10.3945/jn.109.116640PMC PMC2821887
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Abstract

Inflammation may play a role in the pathogenesis of cardiovascular disease and type 2 diabetes, and it has been suggested that the protective effects of whole-grain consumption could be mediated by an effect on inflammation, although few studies have examined the relationships between grain intakes and inflammatory protein concentrations. Our objectives in this study were to examine the associations of whole grain and refined grain intake with plasminogen activator inhibitor type 1 (PAI-1), C-reactive protein (CRP), and fibrinogen plasma concentrations. Cross-sectional data from the Insulin Resistance Atherosclerosis Study were used to perform multiple regression analyses using dietary information on whole and refined grain intakes from a FFQ and clinical measures of plasma inflammatory protein concentrations in participants free of type 2 diabetes. After adjustment for demographic, lifestyle, and dietary variables, whole-grain intake was inversely related to log PAI-1 (beta = -0.102; SEM = 0.038; P = 0.0077) and log CRP (beta = -0.102; SEM = 0.048; P = 0.0340). Adding insulin sensitivity, waist circumference, and 2-h postload glucose to the model attenuated both associations to nonsignificance. Refined grain was positively related to log PAI-1 in the multivariate model (beta = 0.076; SEM = 0.034; P = 0.0251) and the relationship remained unchanged by additional adjustment for metabolic variables. Fibrinogen concentrations were not related to whole or refined grain intake. In summary, whole grain intake was inversely related to PAI-1 and CRP plasma concentrations, but these relationships were attenuated by the addition of metabolic variables to the model. Refined grain intake was positively independently related to plasma PAI-1 concentrations.

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Metadata

Authors
Masters, R. C., Liese, A. D., Haffner, S. M., Wagenknecht, L. E., & Hanley, A. J.
Affiliations
  • University of South Carolina (US)
  • The University of Texas at San Antonio Health Science Center (US)
  • Wake Forest University (US)
  • University of Toronto (CA)
Corresponding author
Hanley, Anthony J.
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2010-03
Volume
140
Issue
3
Pages
587-594
ISSN
0022-3166 (ISSN-L)
DOI
10.3945/jn.109.116640
PMC
PMC2821887
OpenAlex
W2129936669
Cited by
121
References
50
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 12 · 2018: 15 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 12 · 2013: 10 · 2012: 9
FWCI
8.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5u01hl047887-09, 5u01hl047889-09)
  • U.S. Public Health Service (R01-58329)
  • Canadian Institutes of Health Research
  • National Heart, Lung, and Blood Institute (U01HL047902, U01-HL 47889, U01-HL 47887, U01HL047892)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK029867, DK29867)
  • National Center for Research Resources (M01RR000043)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
whole grain intake, dietary fiber, inflammation, plasminogen activator inhibitor-1, C-reactive protein, fibrinogen, insulin sensitivity, type 2 diabetes, cardiovascular disease, Insulin Resistance Atherosclerosis Study
MeSH terms
Adult, C-Reactive Protein, Edible Grain, Diet, Female, Fibrinogen, Humans, Inflammation, Male, Middle Aged, Obesity, Sex Characteristics, Diet Records, Plasminogen Activator Inhibitor 1, Waist Circumference

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