The DOI matches its Crossref record; 118 of the 122 references it cites were found in a registry or an index.
Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling ,
Open accessAbstract
Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior. Peripheral GLP-1 acts on VANs to inhibit food intake. The mechanism of the GLP-1 receptor (GLP-1R) is unlike other gut-derived receptors; GLP-1Rs change their cellular localization according to feeding status rather than their protein concentrations. It is possible that several gut peptides are involved in mediating GLP-1R translocation. The mechanism of peripheral GLP-1R translocation still needs to be elucidated. We review data supporting the role of peripheral GLP-1 acting on VANs in influencing glucose homeostasis and feeding behavior. We highlight evidence demonstrating that GLP-1 interacts with ghrelin and leptin to induce satiation. Our aim was to understand the mechanism of peripheral GLP-1 in the development of noninvasive antiobesity treatments.
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“GLP‐1 and GIP work synergistically to potentiate glucose‐stimulated insulin secretion by pancreatic β‐cells 21.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [21]
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“A major target for gut‐derived hormones is the vagal afferent neurons (VANs) 21.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [21]
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“Ghrelin attenuates insulin production and increases blood glucose concentration by promoting the intracellular localization of the pancreatic β‐cell GLP‐1R under fasting conditions, thus counteracting GLP‐1 signaling 21.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [21]
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Metadata
- Authors
- Ronveaux, C. C., Tomé, D., & Raybould, H. E.
- Affiliations
- AgroParisTech (FR)
- University of California, Davis (US)
- Corresponding author
- Raybould, Helen E
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 145
- Issue
- 4
- Pages
- 672-680
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC4381768
- OpenAlex
- W2049375442
- Cited by
- 124
- References
- 122
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 17 · 2017: 12 · 2016: 9 · 2015: 7
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK041004)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- glucagon-like peptide-1, GLP-1 receptor, vagal afferent neurons, ghrelin, leptin, glucose metabolism, food intake regulation, satiation, glucose homeostasis, receptor translocation, gut-brain signaling
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Blood Glucose, Eating, Humans, Neurons, Afferent, Satiation, Signal Transduction, Receptors, Glucagon, Leptin, Gastrointestinal Tract, Glucagon-Like Peptide 1, Ghrelin
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