Cited by 124Regulation of Appetite and ObesityDiabetes Treatment and ManagementAdipokines, Inflammation, and Metabolic Diseases

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Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling ,

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Ronveaux, Charlotte C, Tomé, Daniel, Raybould, Helen E·2015·The Journal of Nutrition

DOI 10.3945/jn.114.206029PMC PMC4381768

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Abstract

Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior. Peripheral GLP-1 acts on VANs to inhibit food intake. The mechanism of the GLP-1 receptor (GLP-1R) is unlike other gut-derived receptors; GLP-1Rs change their cellular localization according to feeding status rather than their protein concentrations. It is possible that several gut peptides are involved in mediating GLP-1R translocation. The mechanism of peripheral GLP-1R translocation still needs to be elucidated. We review data supporting the role of peripheral GLP-1 acting on VANs in influencing glucose homeostasis and feeding behavior. We highlight evidence demonstrating that GLP-1 interacts with ghrelin and leptin to induce satiation. Our aim was to understand the mechanism of peripheral GLP-1 in the development of noninvasive antiobesity treatments.

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Authors: Ronveaux, C. C., Tomé, D., & Raybould, H. E.
Affiliations: AgroParisTech (FR)
University of California, Davis (US)
Corresponding author: Raybould, Helen E
ORCID: Tomé, Daniel
Raybould, Helen E
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2015-04
Volume: 145
Issue: 4
Pages: 672-680
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.114.206029
PMC: PMC4381768
OpenAlex: W2049375442
Cited by: 124
References: 122
Citations by year: 2026: 12 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 17 · 2017: 12 · 2016: 9 · 2015: 7
FWCI: 1.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2863 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK041004)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: glucagon-like peptide-1, GLP-1 receptor, vagal afferent neurons, ghrelin, leptin, glucose metabolism, food intake regulation, satiation, glucose homeostasis, receptor translocation, gut-brain signaling
MeSH terms: Glucagon-Like Peptide-1 Receptor, Animals, Blood Glucose, Eating, Humans, Neurons, Afferent, Satiation, Signal Transduction, Receptors, Glucagon, Leptin, Gastrointestinal Tract, Glucagon-Like Peptide 1, Ghrelin

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Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling ,

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