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Plasma Concentrations of Trimethylamine-N-oxide Are Directly Associated with Dairy Food Consumption and Low-Grade Inflammation in a German Adult Population
Open accessAbstract
Background Trimethylamine-N-oxide (TMAO) is a metabolite of carnitine, choline, and phosphatidylcholine, which is inversely associated with survival of cardiovascular disease (CVD) patients.Objective We examined the associations of diet with plasma concentrations of TMAO, choline, and betaine and the associations of TMAO with plasma concentrations of various cytokines.Methods Plasma TMAO, choline, and betaine concentrations were measured using LC-high resolution mass spectrometry in 271 participants, ≥18 y old, of the Second Bavarian Food Consumption Survey, conducted in 2002 and 2003. Food consumption was assessed using at least two 24-h dietary recalls. Cytokines were measured in plasma with enzyme-linked immunosorbent assays. Geometric mean concentrations of TMAO, choline, and betaine by categories of meat, dairy food, egg, and fish consumption were computed, adjusted for sex, age, and BMI. Multivariable-adjusted geometric mean concentrations of cytokines [tumor necrosis factor-α (TNF-α), soluble TNF receptors (sTNF-R) p55, sTNF-R p75, interleukin-6 (IL-6), and C-reactive protein (CRP)] were computed by quartiles of TMAO concentration using general linear models.Results Meat, egg, or fish consumption was not associated with TMAO, choline, or betaine concentrations (all P-trend ≥ 0.05). With increases in milk and other dairy food consumption, the plasma TMAO concentration increased [geometric mean bottom quartile of milk consumption: 2.08 μM (95% CI: 1.69, 2.57 μM); compared with top quartile: 3.13 μM (95% CI: 2.56, 3.84 μM); P-trend = 0.008]. Participants in the top TMAO quartile had higher plasma concentrations of TNF-α, sTNF-R p55, and sTNF-R p75 than participants in the bottom quartile (percentage difference ranging between 14.4% and 17.3%; all P-trend < 0.05), but there were no differences in plasma concentrations of CRP and IL-6 (all P-trend ≥ 0.05).Conclusions Results of this study conducted among healthy adults from the general population do not indicate a strong effect of diet on plasma concentrations of TMAO, choline, or betaine, with the exception of a positive association between dairy food consumption and plasma TMAO concentrations. Also, plasma TMAO concentrations were positively associated with inflammation. Whether habitual diet is strongly linked to the plasma TMAO concentration, a potential marker of CVD risk, needs to be determined in further studies.
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“nowadays there is convincing evidence suggesting an association between TMAO and inflammation [8,9,10,11,12]”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [10]
In the citing paper
“The study performed by Rohrmann et al. [10] described a link between low grade inflammation and plasma TMAO levels. When the concentration of plasma TMAO was augmented there was an overexpression of TNF-α, IL-6 and C-reactive protein.”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [10]
In the citing paper
“In a small study in healthy Bavarian subjects, dietary intake of fish, meat, or eggs was not associated with plasma TMAO concentrations, but dairy intake was positively associated with plasma TMAO concentrations (94).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [94]
In the citing paper
“In a study involving 271 participants, consumption of meat, egg, or fish was not associated with TMAO, choline, or betaine concentrations [24].”
From Trimethylamine N-oxide: the good, the bad and the unknown. (2016) · cites this paper as [24]
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Citations
Cites
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,368
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Energy and protein requirements : report of a Joint FAO/WHO/UNU Expert Consultation
Fao, J., Energy, U. E. C. O., & Requirements, P. (1985) · Medical Entomology and Zoology · Cited by 1,857
Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223
Tang, W. H. W., Wang, Z., Fan, Y., Levison, B., Hazen, J. E., Donahue, L. M., Wu, Y., & Hazen, S. L. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.617 · Cited by 681
Wang, Z., Tang, W. H. W., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., Levison, B. S., Fan, Y., Wu, Y., & Hazen, S. L. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu002 · Cited by 559
Micha, R., Michas, G., & Mozaffarian, D. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0282-8 · Cited by 502
Trøseid, M., Ueland, T., Hov, J. R., Svardal, A., Gregersen, I., Dahl, C. P., Aakhus, S., Gude, E., Bjørndal, B., Halvorsen, B., et al. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12328 · Cited by 464
Abete, I., Romaguera, D., Vieira, A. R., Lopez de Munain, A., & Norat, T. (2014) · British Journal of Nutrition · doi:10.1017/s000711451400124x · Cited by 448
The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance
Warrier, M., Shih, D. M., Burrows, A. C., Ferguson, D., Gromovsky, A. D., Brown, A. L., Marshall, S., McDaniel, A., Schugar, R. C., Wang, Z., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.036 · Cited by 414
Shih, D. M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J. M., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m051680 · Cited by 335
Slimani, N., Deharveng, G., Charrondière, R. U., van Kappel, A. L., Ocké, M. C., Welch, A. A., Lagiou, A., van Liere, M. J., Agudo, A., Pala, V. M., et al. (1999) · Computer Methods and Programs in Biomedicine · doi:10.1016/s0169-2607(98)00088-1 · Cited by 330
Tang, W. H. W., Wang, Z., Shrestha, K., Borowski, A. G., Wu, Y., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.11.006 · Cited by 325
Wang, Z., Levison, B. S., Hazen, J. E., Donahue, L., Li, X.-M., & Hazen, S. L. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2014.03.016 · Cited by 320
Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies.
Zheng, J., Huang, T., Yu, Y., Hu, X., Yang, B., & Li, D. (2012) · Public Health Nutrition · doi:10.1017/s1368980011002254 · Cited by 311
Bae, S., Ulrich, C. M., Neuhouser, M. L., Malysheva, O., Bailey, L. B., Xiao, L., Brown, E. C., Cushing-Haugen, K. L., Zheng, Y., Cheng, T.-Y. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1835 · Cited by 253
Miller, C. A., Corbin, K. D., da Costa, K.-A., Zhang, S., Zhao, X., Galanko, J. A., Blevins, T., Bennett, B. J., O’Connor, A., & Zeisel, S. H. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.087692 · Cited by 240
Dietary Precursors of Trimethylamine in Man: A Pilot Study
Zhang, A. Q., Mitchell, S. C., & Smith, R. L. (1999) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00028-9 · Cited by 232
Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., McEntyre, C. J., Elmslie, J. L., Atkinson, W., Molyneux, S. L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114969 · Cited by 223
Mueller, D. M., Allenspach, M., Othman, A., Saely, C. H., Muendlein, A., Vonbank, A., Drexel, H., & von Eckardstein, A. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.091 · Cited by 217
Self-citation[Social class index in the Federal Health Survey].
Winkler, J., & Stolzenberg, H. (1999) · PubMed · Cited by 198
Red and processed meat consumption and risk of stroke: a meta-analysis of prospective cohort studies
Chen, G.-C., Lv, D.-B., Pang, Z., & Liu, Q.-F. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.180 · Cited by 184
Mondul, A. M., Moore, S. C., Weinstein, S. J., Karoly, E. D., Sampson, J. N., & Albanes, D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29576 · Cited by 179
Kaysen, G. A., Johansen, K. L., Chertow, G. M., Dalrymple, L. S., Kornak, J., Grimes, B., Dwyer, T., Chassy, A. W., & Fiehn, O. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2015.02.006 · Cited by 164
Fischer, L. M., Costa, K. A. D., Galanko, J. A., Sha, W., Stephenson, B., Vick, J. A., & Zeisel, S. H. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29459 · Cited by 141
Fish Consumption and the Risk of Stroke: A Dose–Response Meta-Analysis
Larsson, S., & Orsini, N. (2011) · Stroke · doi:10.1161/strokeaha.111.630319 · Cited by 115
Multiple Inflammatory Biomarkers in Relation to Cardiovascular Events and Mortality in the Community
Schnabel, R. B., Yin, X., Larson, M. G., Yamamoto, J. F., Fontes, J. D., Kathiresan, S., Rong, J., Levy, D. A., Keaney, J. F., Wang, T. J., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301174 · Cited by 104
TNF-alpha, soluble TNF receptor and interleukin-6 plasma levels in the general population.
Himmerich, H., Fulda, S., Linseisen, J., Seiler, H., Wolfram, G., Himmerich, S., Gedrich, K., & Pollmächer, T. (2006) · PubMed · Cited by 87
Self-citationThe Immunomodulatory Role of Bile Acids
Sipka, S., & Bruckner, G. G. (2014) · International Archives of Allergy and Immunology · doi:10.1159/000366100 · Cited by 83
Konstantinova, S. V., Tell, G. S., Vollset, S. E., Ulvik, A., Drevon, C. A., & Ueland, P. M. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26531 · Cited by 70
Srinivasa, S., Fitch, K. V., Lo, J., Kadar, H., Knight, R., Wong, K., Abbara, S., Gauguier, D., Capeau, J., Boccara, F., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000565 · Cited by 68
Urinary excretion of methylamines in men with varying intake of fish from the baltic sea
Svensson, B. ‐., Åkesson, B., Nilsson, A., & Paulsson, K. (1994) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399409531853 · Cited by 66
Spillmann, F., Linthout, S. V., Miteva, K., Lorenz, M., Stangl, V., Schultheiss, H., & Tschöpe, C. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.001 · Cited by 55
Abratte, C. M., Wang, W., Li, R., Axume, J., Moriarty, D. J., & Caudill, M. A. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.12.002 · Cited by 54
Voss, S., Charrondière, U. R., Slimani, N., Kroke, A., Ríboli, E., Wahrendorf, J., & Boeing, H. (1998) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s003940050021 · Cited by 52
Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders
Hamlin, J. C., Pauly, M., Melnyk, S., Pavliv, O., Starrett, W., Crook, T. A., & James, S. J. (2013) · Autism Research and Treatment · doi:10.1155/2013/578429 · Cited by 49
Soluble Tumor Necrosis Factor Receptors and Heart Failure Risk in Older Adults
Marti, C. N., Khan, H., Mann, D. L., Georgiopoulou, V. V., Bibbins-Domingo, K. B., Harris, T. B., Koster, A., Newman, A. B., Kritchevsky, S. B., Kalogeropoulos, A. P., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000344 · Cited by 49
Carlsson, A. C., Juhlin, C. C., Larsson, T. E., Larsson, A. O., Ingelsson, E., Sundström, J., Lind, L., & Ärnlöv, J. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.005 · Cited by 38
Soluble TNF Receptors and Kidney Dysfunction in the Elderly
Carlsson, A. C., Larsson, T. E., Helmersson‐Karlqvist, J., Larsson, A. O., Lind, L., & Ärnlöv, J. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080860 · Cited by 36
Eisert, R., Oftedal, O., Lever, M., Ramdohr, S., Breier, B. H., & Barrell, G. K. (2005) · Marine Ecology Progress Series · doi:10.3354/meps300213 · Cited by 35
West, A. A., Shih, Y., Wang, W., Oda, K., Jaceldo‐Siegl, K., Sabaté, J., Haddad, E. H., Rajaram, S., Caudill, M. A., & Burns‐Whitmore, B. (2014) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2014.02.012 · Cited by 29
Cortez‐Cooper, M. Y., Meaders, E., Stallings, J., Haddow, S., Kraj, B., Sloan, G. J., McCully, K. K., & Cannon, J. G. (2013) · Vascular Medicine · doi:10.1177/1358863x13508336 · Cited by 27
Guzmán, M. G., Medraño, J., Rallón, N. I., Echeverria-Urabayen, A., Benito, J. M., Restrepo, C., García–Álvarez, M., Vispo, E., Román, J. S., Sánchez‐Piedra, C., et al. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.08.006 · Cited by 22
Keaveney, E. M., Price, R. K., Hamill, L. L., Wallace, J. M. W., McNulty, H., Ward, M., Strain, J., Ueland, P. M., Molloy, A. M., Piironen, V. I., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003778 · Cited by 17
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Metadata
- Authors
- Rohrmann, S., Linseisen, J., Allenspach, M., von Eckardstein, A., & Müller, D.
- Affiliations
- University of Zurich (CH)
- Helmholtz Munich (DE)
- Corresponding author
- Rohrmann, Sabine
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 146
- Issue
- 2
- Pages
- 283-289
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2231380317
- Cited by
- 197
- References
- 47
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 18 · 2023: 19 · 2022: 22 · 2021: 25 · 2020: 33 · 2019: 17 · 2018: 15 · 2017: 13 · 2016: 5
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Site cant be reached (submittedVersion, cc-by)
- OPUS (Augsburg University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Ministry of Environment
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- trimethylamine N-oxide, milk consumption, choline, betaine, low-grade inflammation, cytokines, TNF-α, soluble TNF receptors, interleukin-6, C-reactive protein, dietary intake, cardiovascular risk, plasma biomarkers, German adults, dietary surveys, dietary assessment, 24-hour dietary recall
- MeSH terms
- Adult, Animals, Betaine, C-Reactive Protein, Choline, Dairy Products, Diet, Diet Surveys, Feeding Behavior, Female, Germany, Humans, Inflammation, Male, Methylamines, Middle Aged, Milk, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Tumor Necrosis Factor, Type I
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