Arginine Metabolism Revisited

Arginine metabolism: nitric oxide and beyond

WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811

Protein Arginine Methylation in Mammals: Who, What, and Why

Bedford, M. T., & Clarke, S. G. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.013 · Cited by 1,810

An amino-acid taste receptor

Nelson, G., Chandrashekar, J. V., Hoon, M. A., Feng, L., Zhao, G., Ryba, N. J. P., & Zuker, C. S. (2002) · Nature · doi:10.1038/nature726 · Cited by 1,523

Arginine metabolism and nutrition in growth, health and disease

Wu, G., Bazer, F. W., Davis, T. A., Kim, S. W., Li, P., Marc Rhoads, J., Carey Satterfield, M., Smith, S. B., Spencer, T. E., & Yin, Y. (2009) · Amino Acids · doi:10.1007/s00726-008-0210-y · Cited by 1,362

Nutrient-sensing mechanisms and pathways

Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110

PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

Vossenaar, E. R., Zendman, A. J. W., VENROOIJ, W. J. V., & Pruijn, G. J. M. (2003) · BioEssays · doi:10.1002/bies.10357 · Cited by 986

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Wang, S., Tsun, Z.-Y., Wolfson, R. L., Shen, K., Wyant, G. A., Plovanich, M., Yuan, E. D., Jones, T. D., Chantranupong, L., Comb, W. C., et al. (2015) · Science · doi:10.1126/science.1257132 · Cited by 865

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Chantranupong, L., Scaria, S. M., Saxton, R. A., Gygi, M. P., Shen, K., Wyant, G. A., Wang, T., Harper, J. W., Gygi, S. P., & Sabatini, D. M. (2016) · Cell · doi:10.1016/j.cell.2016.02.035 · Cited by 843

Arginase: an emerging key player in the mammalian immune system

Munder, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00291.x · Cited by 725

CATs and HATs: the SLC7 family of amino acid transporters

Verrey, F., Closs, E. I., Wagner, C. A., Palacı́n, M., Endou, H., & Kanai, Y. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1086-z · Cited by 709

Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?

Shosha, E., Fouda, A. Y., Narayanan, S. P., Caldwell, R. W., & Caldwell, R. B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020425 · Cited by 26

Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis

Ma, C., Hunt, J. B., Selenica, M.-L. B., Sanneh, A., Sandusky-Beltran, L. A., Watler, M., Daas, R., Kovalenko, A., Liang, H., Placides, D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582998 · Cited by 24

Maternal Undernutrition during Pregnancy Alters Amino Acid Metabolism and Gene Expression Associated with Energy Metabolism and Angiogenesis in Fetal Calf Muscle

Muroya, S., Zhang, Y., Kinoshita, A., Otomaru, K., Oshima, K., Gotoh, Y., Oshima, I., Sano, M., Roh, S., Oe, M., et al. (2021) · Metabolites · doi:10.3390/metabo11090582 · Cited by 24

Daily 100% watermelon juice consumption and vascular function among postmenopausal women: A randomized controlled trial

Ellis, A. C., Mehta, T. S., Nagabooshanam, V. A., Dudenbostel, T., Locher, J. L., & Crowe-White, K. M. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.06.022 · Cited by 25

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Holzmüller, P., Geiger, A., Nzoumbou‐Boko, R., Pissarra, J., Hamrouni, S., Rodrigues, V., Dauchy, F., Lemesre, J.-L., Vincendeau, P., & Bras‐Gonçalves, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00778 · Cited by 23

From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury

Liu, Q., Zhu, X., & Guo, S. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1351 · Cited by 26

L-Arginine and immune modulation: A pharmacological perspective on inflammation and autoimmune disorders

Dimeji, I. Y., Abass, K. S., Audu, N. M., & Adekola, S. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177615 · Cited by 26

Endogenous Metabolic Modulators: Emerging Therapeutic Potential of Amino Acids

Hamill, M. J., Afeyan, R., Chakravarthy, M. V., & Tramontin, T. (2020) · iScience · doi:10.1016/j.isci.2020.101628 · Cited by 24

Predicting lung adenocarcinoma prognosis, immune escape, and pharmacomic profile from arginine and proline-related genes

Wang, Z., Zhang, J., Shi, S., Ma, H., Wang, D., Zuo, C., Zhang, Q., & Lian, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-42541-z · Cited by 21

Circulating arginine metabolites in Alzheimer’s disease and vascular dementia: A systematic review and meta-analysis

Zinellu, A., Tommasi, S., Sedda, S., & Mangoni, A. A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102139 · Cited by 22

Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients

Said, M. Y., Bollenbach, A., Minović, I., van Londen, M., Frenay, A.-R. S., de Borst, M. H., van den Berg, E., Kayacelebi, A. A., Tsikas, D., van Goor, H., et al. (2019) · Amino Acids · doi:10.1007/s00726-019-02725-2 · Cited by 22

Protective effects of distinct proline-rich oligopeptides from B. jararaca snake venom against oxidative stress-induced neurotoxicity

Querobino, S. M., Costa, M. S., & Alberto-Silva, C. (2019) · Toxicon · doi:10.1016/j.toxicon.2019.06.012 · Cited by 22

Preovulatory follicular fluid and serum metabolome profiles in lactating beef cows with thin, moderate, and obese body condition

Horn, E. J., Read, C. C., Edwards, J. L., Schrick, F. N., Rhinehart, J., Payton, R. R., Campagna, S. R., Klabnik, J. L., Clark, H. M., Myer, P. R., et al. (2022) · Journal of Animal Science · doi:10.1093/jas/skac152 · Cited by 21

Metabolic regulation of immune responses to cancer

Wißfeld, J., Werner, A., Yan, X., ten Bosch, N., & Cui, G. (2022) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0381 · Cited by 21

Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Zinellu, A., & Mangoni, A. A. (2023) · Cells · doi:10.3390/cells12172180 · Cited by 21

Mitochondria-engine with self-regulation to restore degenerated intervertebral disc cells via bioenergetic robust hydrogel design

Wang, J., Jiang, Y., Zhu, C., Liu, Z., Qi, L., Ding, H., Wang, J., Huang, Y. X., Li, Y., Song, Y., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.044 · Cited by 21

Analysis of serum metabolome of workers occupationally exposed to hexavalent chromium: A preliminary study

Long, C., Hu, G., Zheng, P., Chen, T., Su, Z., Zhang, Y., Ding, C., Peng, F., Yu, S., Wang, T., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.06.007 · Cited by 21

Effects of l-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials

Rad, E. Y., Nazarian, B., Saboori, S., Falahi, E., & Hekmatdoost, A. (2020) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2020.05.001 · Cited by 20

Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction

Buttner, P. G., Werner, S., Baskal, S., Tsikas, D., Adams, V., Lurz, P. C., Besler, C., Knauth, S., Bahls, M., Schwedhelm, E., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00216-7 · Cited by 20

Biofluids Metabolic Profiling Based on PS@Fe3O4-NH2 Magnetic Beads-Assisted LDI-MS for Liver Cancer Screening.

He, L.-Y., Wang, X., Chen, J.-Y., Li, Y.-Z., Wang, L., Xiong, C.-Q., & Nie, Z. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00654 · Cited by 18

Trichodelphinine A alleviates pulmonary fibrosis by inhibiting collagen synthesis via NOX4-ARG1/TGF-β signaling pathway

Liu, F., Yao, Y., Guo, C., Dai, P., Huang, J., Peng, P., Wang, M., Dawa, Z., Zhu, C., & Lin, C. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155755 · Cited by 20

New insights into the anti- hepatoma mechanism of triple-helix β- glucan by metabolomics profiling

Cai, L., Zhou, S., Wang, Y., Xu, X., Zhang, L., & Cai, Z. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118289 · Cited by 20

L-Arginine Depletion Improves Spinal Cord Injury via Immunomodulation and Nitric Oxide Reduction

Erens, C., Broeckhoven, J. V., Hoeks, C., Schabbauer, G., Cheng, P., Chen, L., Hellings, N., Broux, B., Lemmens, S., & Hendrix, S. (2022) · Biomedicines · doi:10.3390/biomedicines10020205 · Cited by 20

l-Arginine metabolism before and after 10 weeks of antipsychotic treatment in first-episode psychotic patients

Garip, B., Kayır, H., & Uzun, Ö. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.015 · Cited by 21

Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway

Zhang, L., Qu, S., Wang, L., Wang, C., Yu, Q., Zhang, Z., Diao, Y., Zhang, B., Li, Y., Shi, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.661129 · Cited by 20

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

van Gisbergen, M. W., Zwilling, E., & Dubois, L. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.653621 · Cited by 20

Circulating metabolites serve as diagnostic biomarkers for HER2‐positive breast cancer and have predictive value for trastuzumab therapy outcomes

Mao, C., Wang, M., Li, L., & Tang, J. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24212 · Cited by 19

Role of arginine supplementation on muscular metabolism and flesh quality of Pacific white shrimp (Litopenaeus vannamei) reared in freshwater

Li, M., Wen, H., Huang, F., Wu, M., Yu, L., Jiang, M., Lü, X., & Tian, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.980188 · Cited by 19

Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy

Wetzel, M. D., Gao, T., Stanley, K., Cooper, T. K., Morris, S. M., & Awad, A. S. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00518.2019 · Cited by 19

Acylated Homoserine Lactones Regulate the Response of Methane Metabolism and Nitrogen Metabolism to Florfenicol in Anaerobic Fermentation

Zhou, Q., Feng, F., Li, F. L., Liu, J., Wang, M., Huang, S., & Sun, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155035 · Cited by 19

BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

Chen, M., Sun, C., Zhao, R., Guan, X.-L., Li, M.-L., Zhang, F., Wan, Z.-H., Feng, J.-X., Yin, M., Lei, Q., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.05.035 · Cited by 18

Immunometabolism at the service of traditional Chinese medicine

Cui, H., Zhang, J., Cheng, X.-H., Zheng, J., Zhang, Q., Zheng, R., You, L., Han, D., & Shang, H. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106081 · Cited by 18

Approaches to Modulate Biofilm Ecology

Nascimento, M. M. (2019) · Dental Clinics of North America · doi:10.1016/j.cden.2019.07.002 · Cited by 18

Roles of nitric oxide and polyamines in brain tumor growth

Szeliga, M., & Albrecht, J. (2021) · Advances in Medical Sciences · doi:10.1016/j.advms.2021.02.006 · Cited by 17

Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease

Martínez‐González, K., Serrano-Cuevas, L., Almeida‐Gutiérrez, E., Flores, S., Mejía‐Aranguré, J. M., & Garcia-delaTorre, P. (2021) · Nutrition · doi:10.1016/j.nut.2021.111248 · Cited by 18

Dietary guanidinoacetic acid as arginine spare molecule for beef cows at late gestation: Effects on cow’s performance and metabolism, and offspring growth and development

de Sousa, L. C. O., Matos, E. M. A. D., Santos, M. M., Detmann, E., Sampaio, C. B., Sancler-Silva, Y. F. R., Rennó, L. N., Serão, N. V. L., Paulino, P. V. R., Resende, T. L., et al. (2024) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2024.116047 · Cited by 17

Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population

Bahls, M., Atzler, D., Markus, M. R. P., Friedrich, N., Böger, R. H., Völzke, H., Felix, S. B., Schwedhelm, E., & Dörr, M. (2018) · Biomolecules · doi:10.3390/biom8030063 · Cited by 17

Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants

Said, M. Y., Douwes, R. M., van Londen, M., Minović, I., Frenay, A.-R. S., de Borst, M. H., van den Berg, E., Heiner-Fokkema, M. R., Kayacelebi, A. A., Bollenbach, A., et al. (2019) · Amino Acids · doi:10.1007/s00726-018-02693-z · Cited by 17

Synthesis and biological evaluation of [18F](2S,4S)4-(3-fluoropropyl) arginine as a tumor imaging agent.

Wu, R.-B., Liu, S., Liu, Y.-J., Sun, Y., Cheng, X.-B., Huang, Y., Yang, Z., & Wu, Z.-H. (2019) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2019.111730 · Cited by 16

Clozapine-induced transcriptional changes in the zebrafish brain

Viana, J. F., Wildman, N., Hannon, E. J., Farbos, A., Neill, P. O., Moore, K., van Aerle, R., Paull, G. C., Santos, E. M., & Mill, J. S. (2020) · Schizophrenia · doi:10.1038/s41537-019-0092-x · Cited by 17

Metabolomics identifies disturbances in arginine, phenylalanine, and glycine metabolism as differentiating features of exacerbating atopic asthma in children

Cottrill, K. A., Chandler, J. D., Kobara, S., Stephenson, S. T., Mohammad, A. F., Tidwell, M., Mason, C., Dresser, M. V., Patrignani, J., Kamaleswaran, R., et al. (2023) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2023.100115 · Cited by 17

Enhancing Leukemia Treatment: The Role of Combined Therapies Based on Amino Acid Starvation

Chen, C., & Zhang, J. (2024) · Cancers · doi:10.3390/cancers16061171 · Cited by 18

Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression

Janssens, V., Chevronnay, H. P. G., Marie, S., Vincent, M., Smissen, P. V. D., Névo, N., Vainio, S. J., Nielsen, R., Christensen, E. I., Jouret, F., et al. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019040371 · Cited by 16

Synthesis, DFT, Spectroscopic Studies and Electronic Properties of Novel Arginine Derivatives

Almodarresiyeh, H. A., Shаhаb, S., Kaviani, S., Kuvaeva, Z. I., Karankevich, H. G., Маркович, М. М., Kaminskaya, V. A., Filippovich, L., & Sheikhi, M. (2023) · Russian Journal of Physical Chemistry B · doi:10.1134/s1990793123010165 · Cited by 15

Metabolomic Phenotype of Hepatic Steatosis and Fibrosis in Mexican Children Living with Obesity

Garibay-Nieto, N., Pedraza-Escudero, K., Omaña‐Guzmán, I., Garcés-Hernández, M. J., Villanueva-Ortega, E., Flores-Torres, M., Pérez-Hernández, J. L., León-Hernández, M., Laresgoiti‐Servitje, E., Palacios‐González, B., et al. (2023) · Medicina · doi:10.3390/medicina59101785 · Cited by 15

Effect of Air Drying on the Metabolic Profile of Fresh Wild and Artificial Cordyceps sinensis

Wang, T., Tang, C., Xiao, M., Cao, Z., He, M., Qi, J., Li, Y., & Li, X. (2023) · Foods · doi:10.3390/foods13010048 · Cited by 15

Transcriptomic and metabolomic analysis of the mechanisms underlying stress responses of the freshwater snail, Pomacea canaliculata, exposed to different levels of arsenic

Bi, X., Qiu, M., Li, D., Zhang, Y., Zhan, W., Wang, Z., Lv, Z., Li, H., & Chen, G. (2024) · Aquatic Toxicology · doi:10.1016/j.aquatox.2024.106835 · Cited by 15

An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics

Zhou, J., Wang, J., Li, D., Zhang, Z., Wang, C., Zhang, X., Xu, X., & Gao, J. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00214.2023 · Cited by 15

Physiological, transcriptomic and metabolomic analyses reveal that exogenous arginine alleviate the response of Sorghum bicolor L. to cadmium stress

Ye, L., Yu, J., Zhang, X., Yu, F., Zeng, T., Gu, L., Zhu, B., Wang, H., & Du, X. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.120970 · Cited by 15

Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer’s Disease: A Targeted Transcriptome Analysis

Ma, C., Hunt, J. B., Kovalenko, A., Liang, H., Selenica, M. B., Orr, M. B., Zhang, B., Gensel, J. C., Feola, D. J., Gordon, M. N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628156 · Cited by 16

New insights into arginine and arginine-sparing effects of guanidinoacetic acid and citrulline in broiler diets

Dao, H. T., & Swick, R. A. (2021) · World s Poultry Science Journal · doi:10.1080/00439339.2021.1967708 · Cited by 15

Shrunken pore syndrome, preeclampsia, and markers of NO metabolism in pregnant women during the first trimester

Campos, A. J., Risch, L., Baumann, M. U., Purde, M.-T., Neuber, S., Renz, H. E., Mosimann, B., Raio, L., Mohaupt, M. G., Surbek, D., et al. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1568150 · Cited by 14

Functional characterization of arginine metabolic pathway enzymes in the antibacterial immune response of penaeid shrimp

Huang, Z., Zhang, Y., Zheng, X., Liu, Z., Yao, D., Zhao, Y., Chen, X., & Aweya, J. J. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104293 · Cited by 14

Australian Native Plum: A Review of the Phytochemical and Health Effects

Li, J., Liu, H., Mazhar, M. S., Quddus, S., Ağar, O. T., & Suleria, H. A. R. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2172428 · Cited by 15

Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

Guo, T., Hu, S., Xu, W., Zhou, J., Chen, F., Gao, T., Qu, W., Chen, F., Lv, Z., & Lü, L. (2023) · iScience · doi:10.1016/j.isci.2023.106882 · Cited by 14

A systematic review and meta-analysis of nitric oxide-associated arginine metabolites in schizophrenia

Zinellu, A., Tommasi, S., Carru, C., Sotgia, S., & Mangoni, A. A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03157-7 · Cited by 15

Arginine promotes the activation of human lung fibroblasts independent of its metabolism

Hamanaka, R. B., Shin, K. W. D., Atalay, V., Çetin-Atalay, R., Shah, H., Szafran, J. C. H., Woods, P. S., Meliton, A. Y., Shamaa, O. R., Tian, Y., et al. (2025) · Biochemical Journal · doi:10.1042/bcj20253033 · Cited by 16

Integrative serum metabolomic analysis for preventive effects of Yaobitong capsule in adjuvant-induced rheumatoid arthritis rat based on RP/HILIC-UHPLC-Q-TOF MS

Shi, W., Deng, Y., Zhao, C., Xiao, W., Wang, Z., Xiong, Z., & Zhao, L. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114474 · Cited by 14

Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice

Didelija, I. C., Mohammad, M. A., & Marini, J. C. (2017) · Journal of Nutrition · doi:10.3945/jn.117.251249 · Cited by 14

Insight into stem cell regulation from sub-lethally irradiated worms

Rossi, L., Cassella, L., Iacopetti, P., Ghezzani, C., Tana, L., Gimenez, G., Ghigo, É., & Salvetti, A. (2018) · Gene · doi:10.1016/j.gene.2018.04.009 · Cited by 14

Combination of Electrochemistry and Mass Spectrometry to Study Nitric Oxide Metabolism and Its Modulation by Compound K in Breast Cancer Cells

Zhao, M., Liu, X. Z., Hou, Y., Yang, T., Xu, J., & Su, R. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c05492 · Cited by 13

The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice

Xiaowei, L., Zhou, L., Wang, S., Yuan, J., Chang, Z., Hu, Q., Chen, Y., Liu, Y., Huang, Y. F., Wang, B., et al. (2022) · Molecules · doi:10.3390/molecules27238237 · Cited by 13

LC–MS-based serum metabolomics analysis for the screening and monitoring of colorectal cancer

Yi, Y., Wang, J., Liang, C., Ren, C., Xu, L., Han, C., & Sun, W. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1173424 · Cited by 13

Liver Metabolome and Proteome Response of Turbot (Scophthalmus maximus) to Lysine and Leucine in Free and Dipeptide Forms

Wei, Y., Li, B., Xu, H., & Liang, M. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.691404 · Cited by 13

Integrated proteomics and metabolomics reveal variations in pulmonary fibrosis development and the potential therapeutic effect of Shuangshen Pingfei formula

Chen, Y., Li, X., & Fan, X. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115894 · Cited by 13

Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator

Wang, G., Xu, R., Zhang, B., Hong, X., Bartell, T. R., Pearson, C., Liang, L., & Wang, X. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01473-1 · Cited by 12

Advances and Perspectives in Relation to the Molecular Basis of Diabetic Retinopathy—A Review

Błaszkiewicz, M., Walulik, A., Florek, K., Górecki, I., Sławatyniec, O., & Gomułka, K. (2023) · Biomedicines · doi:10.3390/biomedicines11112951 · Cited by 14

Mechanism of electro-acupuncture in alleviating intestinal injury in septic mice via polyamine-related M2-macrophage polarization

Xu, X., Huang, X., Xiao, L., Wang, J., Yang, X., & Wu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1373876 · Cited by 14

Anti-Inflammation of Torachrysone-8-O-β-ᴅ-Glucoside by Hurdling Over Morphological Changes of Macrophages

Zhao, W., Xu, D., Zhang, L., Meng, H., Zheng, Q., & Wang, J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108548 · Cited by 12

The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer

Vadlakonda, L., Indracanti, M., Kalangi, S. K., Gayatri, B. M., Gajula, N. N., & Reddy, A. B. M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00566-5 · Cited by 11

Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system

Wu, X., Sun, X., Sharma, S., Lü, Q., Yegambaram, M., Hou, Y., Wang, T., Fineman, J. R., & Black, S. M. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.12.003 · Cited by 11

Altered Brain Arginine Metabolism and Polyamine System in a P301S Tauopathy Mouse Model: A Time-Course Study

Mein, H., Yu, J., Ahmad, F., Zhang, H., & Liu, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116039 · Cited by 11

Zinc Imidazole Framework‐8 Nanoparticles Disperse MRSA Biofilm by Inhibiting Arginine Biosynthesis and Down‐Regulating Adhesion‐Related Proteins

Tian, X., Liu, B., Wu, H., Cai, R., Yang, Y., Zhou, C., Zhao, Z., Bai, Q., Wang, Y., & Liu, T. (2024) · Advanced Materials Interfaces · doi:10.1002/admi.202300957 · Cited by 12

Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef bulls

Wang, J., Shen, C., Zhao, G., Hanigan, M. D., & Li, M. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.04.028 · Cited by 12

Multi-Omics Integrative Analyses Identified Two Endotypes of Hip Osteoarthritis

Huang, J., Liu, M., Zhang, H., Sun, G., Furey, A. J., Rahman, P., & Zhai, G. (2024) · Metabolites · doi:10.3390/metabo14090480 · Cited by 11

Metabolic Modulation of Yogurt Fermentation Kinetics and Storage Stability by Lactobacillus-Starter Culture Interactions

An, M., Zhao, Z., Zhao, L., Yang, J., Gao, H., Zhang, L., Zhao, G., Hou, B., He, J., Hung, W., et al. (2025) · Foods · doi:10.3390/foods14172935 · Cited by 11

Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

Demir, B., Çiçek, D., Orhan, C., Er, B., Erten, F., Tuzcu, M., Özercan, İ. H., Şahin, N., Komorowski, J. R., Ojalvo, S. P., et al. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03176-9 · Cited by 11

The effects of oral arginine on its metabolic pathways in Sprague–Dawley rats

Martin, S., & Desai, K. M. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519002691 · Cited by 11

Derangement of Arginine and Related Amino Acids in Children Undergoing Surgery for Congenital Heart Disease With Cardiopulmonary Bypass

Navaei, A., Shekerdemian, L. S., Mohammad, M. A., Coss‐Bu, J. A., Bastero, P., Ettinger, N., Orellana, R. A., Fernandes, C. J., & Marini, J. C. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000150 · Cited by 11

Flagellin From Pseudomonas Aeruginosa Stimulates ATB0,+ Transporter for Arginine and Neutral Amino Acids in Human Airway Epithelial Cells

Barilli, A., Visigalli, R., Ferrari, F., Borsani, G., Dall’Asta, V., & Rotoli, B. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.641563 · Cited by 11

Arginine catabolism metabolites and atrial fibrillation or heart failure risk: 2 case-control studies within the Prevención con Dieta Mediterránea (PREDIMED) trial

Goñi, L., Razquín, C., Toledo, E., Guasch‐Ferré, M., Clish, C. B., Babió, N., Wittenbecher, C., Atzeni, A., Li, J., Liang, L., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac139 · Cited by 11

The mechanism of formononetin/calycosin compound optimizing the effects of temozolomide on C6 malignant glioma based on metabolomics and network pharmacology

Li, S., Li, J., Fan, Y., Huang, T., Zhou, Y., Fan, H., Zhang, Q., & Qiu, R. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113418 · Cited by 11

Streptococcal arginine deiminase regulates endothelial inflammation, mTOR pathway and autophagy

Mammedova, J. T., Av, S., Burova, L. A., Karaseva, A. B., Грудинина, Н. А., Gorbunov, N., Malashicheva, A., Semenova, D., Kiseleva, E. P., & Старикова, Э. А. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152344 · Cited by 11

Arginine transportation mechanism through cationic amino acid transporter 1: insights from molecular dynamics studies

Afshinpour, M., & Mahdiuni, H. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2175374 · Cited by 10

The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis

Liu, T. Y. A., Stewart, T. M., & Casero, R. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158173 · Cited by 10

The influence of ancillary NCS− ions on structural, spectroscopic, magnetic and biological properties of copper(II) l-argininato complex

Wojciechowska, A., Janczak, J., Rytlewski, P., Sarewicz, M., Santos, A. C. F., Salgueiro, L., & Korabik, M. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134776 · Cited by 10

Peptide fraction from B. jararaca snake venom protects against oxidative stress-induced changes in neuronal PC12 cell but not in astrocyte-like C6 cell

Santos, H. Q. P., da Silva, J. C. A., da Silva, B. R., Echeverry, M. B., & Alberto-Silva, C. (2023) · Toxicon · doi:10.1016/j.toxicon.2023.107178 · Cited by 10

Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial

Tadié, J., Locher, C., Maamar, A., Reignier, J., Asfar, P., Commereuc, M., Lesouhaitier, M., Grégoire, M., Pabic, E. L., Bendavid, C., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04651-y · Cited by 11

Regulation of dendritic cell biology by amino acids and their transporters

Chen, S.-L., Li, G., Jiang, Z., Xu, Y., Aipire, A., & Li, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626973 · Cited by 13

The Sexual Effect of Chicken Embryos on the Yolk Metabolites and Liver Lipid Metabolism

Ding, P., Tong, Y., Wu, S., Yin, X., Liu, H., He, X., Song, Z., & Zhang, H. (2021) · Animals · doi:10.3390/ani12010071 · Cited by 10

Metabolomics approach to elucidate the importance of count size in commercial penaeid shrimps: white leg shrimp (Litopenaeus vannamei) and black tiger shrimp (Penaeus monodon)

Putri, S. L. E., Suantika, G., Situmorang, M. L., Putri, S. P., & Fukusaki, E. (2022) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2022.01.010 · Cited by 9

Metabolic regulation of type 2 immune response during tissue repair and regeneration

Ding, T., & Ge, S. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0422-665r · Cited by 10

Development of a novel Ultra Performance Liquid Chromatography Tandem-Mass Spectrometry (UPLC-MS/MS) method to measure l-arginine metabolites in plasma

Santucci, L., Lomuscio, S., Primiano, A., Calvani, R., Persichilli, S., Iavarone, F., Picca, A., Canu, F., Urbani, A., & Gervasoni, J. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117306 · Cited by 9

Poly(amino acids) towards sensing pathogenic bacteria: A review

Al-Hawary, S. I. S., Jawad, M. A., Jawhar, Z. H., Romero‐Parra, R. M., Ramírez‐Coronel, A. A., Fenjan, M. N., & Gabr, G. A. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108798 · Cited by 9

Comparative analysis of bile metabolic profile in patients with biliary obstruction complicated by Clonorchis sinensis infection

Zhang, X., Han, S., Jiang, X., Duan, S., Gao, Y., Ding, J., Li, X., Sun, B., Hu, X., Zhang, X., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1254016 · Cited by 9

Metabolomics analysis of the potential anticancer mechanism of annonaceous acetogenins on a multidrug resistant mammary adenocarcinoma cell

Ma, C., Li, Y., Wu, H., Ji, J., Sun, Q., Song, Y., Wang, S., Li, X., Chen, Y., & Chen, J. (2018) · Analytical Biochemistry · doi:10.1016/j.ab.2018.04.022 · Cited by 9

Lactoferrin Supplementation during Gestation and Lactation Is Efficient for Boosting Rat Pup Development

Blais, A., Lan, A., Boluktas, A., Grauso, M., Chaumontet, C., Blachier, F., & Davila, A. (2022) · Nutrients · doi:10.3390/nu14142814 · Cited by 9

Comparative analysis of biological aspects of Leishmania infantum strains

Ferreira-Paes, T., Charret, K. S., Ribeiro, M. R. D. S., Rodrigues, R. F., & Leon, L. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230545 · Cited by 9

Arginine at the host-pathogen interface

Ryan, B. E., & Mike, L. A. (2025) · Infection and Immunity · doi:10.1128/iai.00612-24 · Cited by 10

Arginine Metabolism: Boundaries of Our Knowledge

Morris, S. M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1602s · Cited by 649

Arginine metabolism: nitric oxide and beyond

WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811

Arginine: beyond protein

Morris, S. M. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.508s · Cited by 430

Enzymes of Arginine Metabolism

Morris, S. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2743s · Cited by 361

Arginine metabolism in vascular biology and disease

Morris, S. M. (2005) · Vascular Medicine · doi:10.1177/1358836x0501000112 · Cited by 85