Phenylpropanolamine and stroke: The study, the FDA ruling, the implications
Abstract
Following a recent case-control study that linked the use of phenylpropanolamine (PPA) in diet aids to the risk of hemorrhagic stroke, the Food and Drug Administration requested that drug companies stop marketing products that contain PPA. Dozens of over-the-counter and prescription diet aids and cough and cold remedies will need to be reformulated or discontinued. This paper reviews the study and its implications for physicians.
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The association of sympathomimetic amines with dose-related increases in blood pressure has been well established.
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From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [215]
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- Authors
- VIDT, D. G., & MERSFELDER, T. L.
- Affiliations
- Ferris State University (US)
- ORCID
- MERSFELDER, T. L.
- Venue
- Cleveland Clinic Journal of Medicine
- Publisher
- Cleveland Clinic Journal of Medicine
- Published
- 2001-03-01
- Volume
- 68
- Issue
- 3
- Pages
- 208-223
- ISSN
- 0891-1150 (ISSN-L)
- 1939-2869
- OpenAlex
- W2090310866
- Cited by
- 26
- References
- 0
- Citations by year
- 2025: 1 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cleveland Clinic Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- phenylpropanolamine, hemorrhagic stroke, weight loss supplements, drug safety, over-the-counter drugs, cough and cold remedies, case-control study
- MeSH terms
- Adolescent, Adrenergic alpha-Agonists, Adult, Age Factors, Appetite Depressants, Child, Data Interpretation, Statistical, Nonprescription Drugs, Ephedrine, Female, Humans, Male, Middle Aged, Phenylpropanolamine, Drug Prescriptions, Risk Factors, Sex Factors, Sympathomimetics, Time Factors, United States, United States Food and Drug Administration, Nasal Decongestants, Odds Ratio, Case-Control Studies, Stroke
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