Role of Reactive Oxygen Species-Related Enzymes in Neuropeptide Y and Proopiomelanocortin-Mediated Appetite Control: A Study Using Atypical Protein Kinase C Knockdown
Abstract
Aims: Studies have reported that redox signaling in the hypothalamus participates in nutrient sensing. The current study aimed to determine if the activation of reactive oxygen species-related enzymes (ROS-RE) in the hypothalamus participates in regulating neuropeptide Y (NPY)-mediated eating. Moreover, possible roles of proopiomelanocortin (POMC) and atypical protein kinase C (aPKC) were also investigated. Rats were treated daily with phenylpropanolamine (PPA) for 4 days. Changes in the expression levels of ROS-RE, POMC, NPY, and aPKC were assessed and compared. Results: Results showed that ROS-RE, POMC, and aPKC increased, with a maximal response on Day 2 (anorectic effect) and with a restoration to the normal level on Day 4 (tolerant effect). By contrast, NPY expression decreased, and the expression pattern of NPY proved opposite those of ROS-RE and POMC. Central inhibition of ROS production by ICV infusion of ROS scavenger attenuated PPA anorexia, revealing a crucial role of ROS in regulating eating. Cerebral aPKC knockdown by ICV infusion of antisense aPKC modulated the expression of ROS-RE, POMC, and NPY. Conclusion: Results suggest that ROS-RE/POMC- and NPY-containing neurons function reciprocally in regulating both the anorectic and tolerant effects of PPA, while aPKC is upstream of these regulators. Innovation: These results may further the understanding of ROS-RE and aPKC in the control of PPA anorexia. Antioxid. Redox Signal. 15, 2147–2159.
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Various kinases and transcription factors involved in neuropeptide regulation have been reported to be modulated by redox signaling.
“Various kinases and transcription factors, involved in neuropeptide regulation, have been reported to be modulated by redox signaling ([33](#B33), [91](#B91)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [91]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
Bethke, T. D. (2012) · Der Pneumologe · doi:10.1007/s10405-012-0601-3 · Cited by 3,286 · see citing works
Protein kinase C and lipid signaling for sustained cellular responses
Nishizuka, Y. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737456 · Cited by 2,499 · see citing works
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature · doi:10.1038/nature07181 · Cited by 710 · see citing works
Neuroendocrine control of food intake
Valassi, E., Scacchi, M., & Cavagnini, F. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.06.004 · Cited by 650 · see citing works
Glucoreceptors Controlling Feeding and Blood Glucose: Location in the Hindbrain
Ritter, R. C., Slusser, P. G., & Stone, S. L. (1981) · Science · doi:10.1126/science.6264602 · Cited by 470 · see citing works
Wynne, K., Stanley, S., McGowan, B. M., & Bloom, S. R. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05866 · Cited by 452 · see citing works
Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATPChannels
Ibrahim, N., Bosch, M. A., Smart, J. L., Qiu, J., Rubinstein, M., Rønnekleiv, O. K., Low, M. J., & Kelly, M. J. (2003) · Endocrinology · doi:10.1210/en.2002-221033 · Cited by 355 · see citing works
Mechanism of alcohol-induced oxidative stress and neuronal injury
Haorah, J., Ramirez, S. H., Floreani, N. A., Gorantla, S., Morsey, B., & Persidsky, Y. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.030 · Cited by 349 · see citing works
Numazawa, S., Ishikawa, M., Yoshida, A., Tanaka, S., & Yoshida, T. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00043.2003 · Cited by 316 · see citing works
Neuronal localisation of neuropeptide Y gene expression in rat brain
MORRIS, B. J. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902900305 · Cited by 292 · see citing works
Characterization of Glucosensing Neuron Subpopulations in the Arcuate Nucleus
Fioramonti, X., Contié, S., Song, Z., Routh, V. H., Lorsignol, A., & Pénicaud, L. (2007) · Diabetes · doi:10.2337/db06-0567 · Cited by 225 · see citing works
Guo, Z., Jiang, H., Xu, X. Z. S., Duan, W., & Mattson, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703753200 · Cited by 202 · see citing works
The melanocortin system and energy balance
Butler, A. A. (2006) · Peptides · doi:10.1016/j.peptides.2005.02.029 · Cited by 196 · see citing works
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis
Jordan, S. D., Könner, A. C., & Brüning, J. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0414-7 · Cited by 163 · see citing works
Horváth, T. L., Naftolin, F. N., Kalra, S. P., & Leranth, C. (1992) · Endocrinology · doi:10.1210/endo.131.5.1425443 · Cited by 161 · see citing works
Sternberger, L. A., & Sternberger, N. H. (1986) · Journal of Histochemistry & Cytochemistry · doi:10.1177/34.5.3517144 · Cited by 161 · see citing works
Fuel utilization by hypothalamic neurons: roles for ROS.
Horvath, T., Andrews, Z., & Diano, S. (2009) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2008.10.003 · Cited by 159 · see citing works
Widnell, K. L., Self, D. W., Lane, S. B., Russell, D., Vaidya, V. A., Miserendino, M. J. D., Rubin, C. S., Duman, R. S., & Nestler, E. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12267-2 · Cited by 156 · see citing works
Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: Behavioral correlates
Zhang, M., & Creese, I. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90299-z · Cited by 151 · see citing works
Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects
Giorgi, C., Agnoletto, C., Baldini, C., Bononi, A., Bonora, M., Marchi, S., Missiroli, S., Patergnani, S., Poletti, F., Rimessi, A., et al. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2825 · Cited by 150 · see citing works
Role for Mitochondrial Reactive Oxygen Species in Brain Lipid Sensing
Bénani, A., Troy, S., Carmona, M. C., Fioramonti, X., Lorsignol, A., Leloup, C., Casteilla, L., & Pénicaud, L. (2006) · Diabetes · doi:10.2337/db06-0440 · Cited by 127 · see citing works
Horváth, T. L. (1992) · Endocrinology · doi:10.1210/en.131.5.2461 · Cited by 91 · see citing works
Long, J., Gao, F., Tong, L., Cotman, C. W., Ames, B. N., & Liu, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9850-2 · Cited by 86 · see citing works
Zheng, H., Patterson, L. M., Rhodes, C. J., Louis, G. W., Skibicka, K. P., Grill, H. J., Myers, M. G., & Berthoud, H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00619.2009 · Cited by 84 · see citing works
Minor, R. K., Chang, J. W., & de Cabo, R. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.044 · Cited by 75 · see citing works
Review Paper: Current Strategies in the Development of Anti-obesity Drugs and Their Safety Concerns
Elangbam, C. S. (2008) · Veterinary Pathology · doi:10.1354/vp.46-1-10 · Cited by 66 · see citing works
Sharma, D., Sethi, P., Hussain, E., & Singh, R. (2008) · Biogerontology · doi:10.1007/s10522-008-9195-x · Cited by 64 · see citing works
Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition
Jaillard, T., Roger, M., Galinier, A., Guillou, P., Bénani, A., Leloup, C., Casteilla, L., Pénicaud, L., & Lorsignol, A. (2009) · Diabetes · doi:10.2337/db08-1039 · Cited by 64 · see citing works
Shao, L., Cui, J., Young, L. T., & Wang, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.041 · Cited by 63 · see citing works
Tsakiris, P., de la Rosette, J. J. M. C. H., Michel, M. C., & Oelke, M. (2007) · European Urology · doi:10.1016/j.eururo.2007.09.037 · Cited by 57 · see citing works
Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke
Yoon, B., Bae, H., Hong, K., Lee, S. M., Park, B., Yu, K. H., Han, M., Lee, Y. S., Chung, D. K., Park, J. M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000250351.38999.f2 · Cited by 56 · see citing works
Atypical Protein Kinase C in Neurodegenerative Disease I
Crary, J. F., Shao, C., Mirra, S. S., Hernandez, A. I., & Sacktor, T. C. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000218442.07664.04 · Cited by 50 · see citing works
Involvement of PKC‐ι in glioma proliferation
Patel, R. S., Win-Piazza, H., Desai, S., Patel, K., Matthews, J. A., & Acevedo-Duncan, M. E. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00506.x · Cited by 49 · see citing works
Ghosh, M. K., Ghosh, K., Dahl, O., & Cohen, J. S. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.24.5761 · Cited by 48 · see citing works
Wellman, P. J., & Davies, B. T. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90452-l · Cited by 44 · see citing works
Current Status of Antisense DNA Methods in Behavioral Studies
Ogawa, S., & Pfaff, D. W. (1998) · Chemical Senses · doi:10.1093/chemse/23.2.249 · Cited by 42 · see citing works
Chen, J., Zhang, Y., & Shen, P. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.008 · Cited by 36 · see citing works
Acute ethanol exposure disrupts actin cytoskeleton and generates reactive oxygen species in c6 cells
Loureiro, S. O., Heimfarth, L., Reis, K. P., Wild, L., Andrade, C. M. B., Guma, F. T. C. R., Gonçalves, C. A., & Pessoa‐Pureur, R. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.09.003 · Cited by 30 · see citing works
Sucajtys-Szulc, E., Turyn, J., Goyke, E., Korczyńska, J., Stelmańska, E., Slominska, E. M., Smolenski, R. T., Rutkowski, B., & Świerczyński, J. (2009) · Neuropeptides · doi:10.1016/j.npep.2009.11.005 · Cited by 30 · see citing works
Zhao, F., Ilbert, M., Varadan, R., Cremers, C. M., Hoyos, B. E., Acín‐Pérez, R., Vinogradov, V., Cowburn, D., Jakob, U., & Hämmerling, U. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3773 · Cited by 29 · see citing works
Hopf, F. W., Mailliard, W. S., Gonzalez, G. F., Diamond, I., & Bonci, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3099-04.2005 · Cited by 27 · see citing works
Thaler, J. P., Choi, S. J., Sajan, M. P., Ogimoto, K., Hồng, N. T., Matsen, M. E., Benoit, S. C., Wisse, B. E., Farese, R. V., & Schwartz, M. W. (2009) · Endocrinology · doi:10.1210/en.2009-0509 · Cited by 26 · see citing works
Phenylpropanolamine and stroke: The study, the FDA ruling, the implications
VIDT, D. G., & MERSFELDER, T. L. (2001) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.68.3.208 · Cited by 26 · cited 1× · see citing works
“PPA, now withdrawn from the market, had the risks of myocardial injury and hemorrhagic stroke (33, 44).”
Cheng, J., & Kuo, D. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00637-2 · Cited by 26 · see citing works
Self-citationCase report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction
Pilsczek, F. H., Karcic, A. A., & Freeman, I. (2003) · Heart & Lung · doi:10.1067/mhl.2003.27 · Cited by 22 · see citing works
Effect of MAO-B Inhibition against Ischemia-induced Oxidative Stress in the Rat Brain
Seif-El-Nasr, M., Atia, A., & Abdelsalam, R. M. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1296487 · Cited by 22 · see citing works
Roßner, S., Mehlhorn, G., Schliebs, R., & Bigl, V. (2001) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2001.01388.x · Cited by 21 · see citing works
Exogenous Leptin Increases Lipid Peroxidation in the Mouse Brain
Kutlu, S., Canpolat, S., Aydın, M., Yaşar, A., Tuzcu, M., & Baydaş, G. (2005) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.206.233 · Cited by 20 · see citing works
Stier, B. G., & Hennekens, C. H. (2005) · Annals of Epidemiology · doi:10.1016/j.annepidem.2005.01.012 · Cited by 20 · see citing works
Exacerbation of Psychosis by Phenylpropanolamine
GOODHUE, A., BARTEL, R. L., & SMITH, N. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.1021-a · Cited by 16 · see citing works
Penzner, J. H., Thompson, D. L., Arth, C., Fowler, J. K., Ary, A. W., & Szumlinski, K. K. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00101.x · Cited by 14 · see citing works
Atypical PKC-ζ and PKC-ι mediate opposing effects on MCF-7 Na+/K+ATPase activity
Muscella, A., Storelli, C., & Marsigliante, S. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20396 · Cited by 14 · see citing works
Biochemical assays for multiple activation states of protein kinase C
Yamamoto, T., Matsuzaki, H., Kamada, S., Ono, Y., & Kikkawa, U. (2006) · Nature Protocols · doi:10.1038/nprot.2006.420 · Cited by 14 · see citing works
Hsieh, Y., Yang, S., Chiou, H., & Kuo, D. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.933 · Cited by 13 · see citing works
Self-citationKuo, D., Yang, S., Chu, S., Chen, C.-H., Chen, P., & Hsieh, Y. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06843.x · Cited by 12 · see citing works
Self-citationCao, G., Gardner, A., & Westfall, T. C. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.003 · Cited by 11 · see citing works
Hsieh, Y., Hsu, J., Yang, S., & Kuo, D. (2004) · Peptides · doi:10.1016/j.peptides.2004.08.015 · Cited by 11 · see citing works
Self-citationHsieh, Y., Yang, S., Chu, S., & Kuo, D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04919.x · Cited by 10 · see citing works
Self-citationKuo, D., Yang, S., Chu, S., Chen, C.-H., & Hsieh, Y. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05909.x · Cited by 9 · see citing works
Self-citationInhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine
Zaloga, G. P., Clark, J. D., & Roberts, P. R. (2000) · Critical Care Medicine · doi:10.1097/00003246-200011000-00024 · Cited by 8 · see citing works
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Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works
Drougard, A., Fournel, A., Valet, P., & Knauf, C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00056 · Cited by 90 · see citing works
Gyengési, E., Paxinos, G., & Andrews, Z. B. (2012) · Current Neuropharmacology · doi:10.2174/157015912804499438 · Cited by 46 · see citing works
Gyengési, E., Paxinos, G., & Andrews, Z. B. (2012) · Current Neuropharmacology · doi:10.2174/157015912804143496 · Cited by 61 · see citing works
Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication
Toh, P., Nicholson, J. L., Vetter, A. M., Berry, M. J., & Torres, D. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315445 · Cited by 42 · see citing works
Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins
Gong, T., Torres, D. J., Berry, M. J., & Pitts, M. W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.038 · Cited by 37 · see citing works
Zhao, F., Ilbert, M., Varadan, R., Cremers, C. M., Hoyos, B. E., Acín‐Pérez, R., Vinogradov, V., Cowburn, D., Jakob, U., & Hämmerling, U. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3773 · Cited by 29 · see citing works
Fuentes‐Medel, E., Venegas, B., Muñoz‐Arenas, G., Morán, C., Vázquez‐Roque, R. A., Flores, G., Treviño, S., Díaz, A., & Guevara, J. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102237 · Cited by 28 · see citing works
The Anorexigenic Effect of Serotonin Is Mediated by the Generation of NADPH Oxidase-Dependent ROS
Fang, X.-L., Shu, G., Yu, J., Wang, L., Yang, J., Zeng, Q.-J., Cheng, X. L., Zhang, Z., Wang, S., Gao, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053142 · Cited by 27 · see citing works
Chu, S., Chen, P., Hsieh, Y., Yu, C., Lin, M., Lin, Y., & Kuo, D. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12667 · Cited by 27 · see citing works
Self-citationHigh- and low- selenium diets affect endocrine energy balance during early programming
Ojeda, M. L., Carreras, O., Díaz‐Castro, J., Murillo, M. L. O., & Nogales, F. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114744 · Cited by 20 · see citing works
Kuo, D., Chen, P., Yu, C., Kuo, M.-H., Hsieh, Y., & Chu, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.018 · Cited by 20 · see citing works
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Nguyen, P. H., Greene, E. S., Kong, B. C., Bottje, W. G., Anthony, N. B., & Dridi, S. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01079 · Cited by 20 · see citing works
Hsieh, Y., Chen, P., Yu, C., Chen, C., Tsai, T.-T., & Kuo, D. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.03.011 · Cited by 18 · see citing works
Self-citationFunakoshi, T., Aki, T., Unuma, K., & Uemura, K. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.056 · Cited by 18 · see citing works
Hsieh, Y., Chen, P. ‐., Yu, C. ‐., & Kuo, D. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12174 · Cited by 18 · see citing works
Self-citationBoth neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control
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Self-citationKuo, D., Chen, P., Chu, S., & Hsieh, Y. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0761-7 · Cited by 13 · see citing works
Self-citationHsieh, Y., Chen, P., Yu, C., Liao, J., & Kuo, D. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-46 · Cited by 13 · see citing works
Self-citationChen, A., Li, W., Chen, X., Shen, Y., Dai, W., Dong, Q., Li, X., Ou, C., & Chen, M. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0399-8 · Cited by 13 · see citing works
Chu, S., Chen, P., Chen, J., Yu, C., Hsieh, Y., & Kuo, D. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.12.019 · Cited by 13 · see citing works
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Self-citationChu, S., Yu, C., Chen, P., Hsieh, Y., & Kuo, D. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.025 · Cited by 8 · see citing works
Self-citationBudzyński, J., Ziółkowski, M., Kłopocka, M., & Czarnecki, D. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.10.004 · Cited by 8 · see citing works
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Self-citationYu, C., Hsieh, Y., Chen, P., Chen, J., & Kuo, D. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14120 · Cited by 7 · see citing works
Self-citationKuo, D., Chen, P., & Hsieh, Y. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1252-4 · Cited by 7 · see citing works
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Self-citationMarkkula, S. P., Lyons, D. J., Yueh, C.-Y., Riches, C. H., Hurst, P., Fielding, B. A., Heisler, L. K., & Evans, M. L. (2016) · Endocrinology · doi:10.1210/en.2015-2054 · Cited by 6 · see citing works
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Self-citationHsieh, Y., Chen, P., Kuo, M.-H., & Kuo, D. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0947-7 · Cited by 6 · see citing works
Self-citationTorres, D. J., Pitts, M. W., Seale, L. A., Hashimoto, A. C., An, K. J., Hanato, A. N., Hui, K. W., Remigio, S. M. A., Carlson, B. A., Hatfield, D. L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011010 · Cited by 5 · see citing works
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Chu, S., Chen, P., Yu, C., Hsieh, Y., & Kuo, D. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.08.301 · Cited by 5 · see citing works
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Erdogan, C. S., Yavuz, Y., Özgün, H. B., Bilgin, V. A., Ağuş, S., Kalkan, U. F., & Yılmaz, B. (2025) · Acta Physiologica · doi:10.1111/apha.70020 · Cited by 3 · see citing works
Simonds, S. E., Pryor, J. T., Lam, B., Dowsett, G. K. C., Mustafa, T., Munder, A. C., Elysee, K., Balland, É., Cowley, L. O., Yeo, G. S. H., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101936 · Cited by 2 · see citing works
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Lyngdoh, J., Wahlang, J. B., & Nongkynrih, B. (2015) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20151135 · Cited by 1 · see citing works
Yu, C., Chu, S., Chen, P. ‐., Hsieh, Y., & Kuo, D. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12360 · Cited by 1 · see citing works
Self-citationOrectic And Anorectic Peptides And Their Implication In Obesity And The Metabolic Syndrome
Bodea, A., & Popa, A. R. (2015) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.1515/rjdnmd-2015-0023
Amphetamine Acts Through the Melanocortin System to Regulate Metabolism and Cardiovascular FunctionPreprint
Simonds, S. E., Pryor, J. T., Lam, B., Dowsett, G. K. C., Mustafa, T., Munder, A. C., Elysee, K., Balland, É., Cowley, L. O., Yeo, G. S. H., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4088891
- Authors
- Kuo, D.-Y., Chen, P.-N., Yang, S.-F., Chu, S.-C., Chen, C.-H., Kuo, M.-H., Yu, C.-H., & Hsieh, Y.-S.
- Affiliations
- Chung Shan Medical University Hospital (TW)
- Central Taiwan University of Science and Technology (TW)
- National Taichung Second Senior High School
- Corresponding author
- Hsieh, Yih-Shou
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-10
- Volume
- 15
- Issue
- 8
- Pages
- 2147-2159
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2080681608
- Cited by
- 41
- References
- 63
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chung Shan Medical University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- reactive oxygen species, neuropeptide Y, proopiomelanocortin, atypical protein kinase C, appetite regulation, phenylpropanolamine, anorexia, tolerance (pharmacology and immunology), hypothalamus, redox signaling, ROS scavengers, antisense knockdown, dietary habits
- MeSH terms
- Animals, Appetite Regulation, Male, Neuropeptide Y, Phenylpropanolamine, Pro-Opiomelanocortin, Protein Kinase C, Blotting, Western, Rats, Wistar, Reactive Oxygen Species, Reverse Transcriptase Polymerase Chain Reaction, Rats
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