The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Acute Respiratory Distress Syndrome: Pathophysiology and Therapeutic Options
Open accessAbstract
UNLABELLED: Acute Respiratory Distress Syndrome (ARDS) is a common entity in critical care. ARDS is associated with many diagnoses, including trauma and sepsis, can lead to multiple organ failure and has high mortality. The present article is a narrative review of the literature on ARDS, including ARDS pathophysiology and therapeutic options currently being evaluated or in use in clinical practice. The literature review covers relevant publications until January 2011. Recent developments in the therapeutic approach to ARDS include refinements of mechanical ventilatory support with emphasis on protective lung ventilation using low tidal volumes, increased PEEP with use of recruitment maneuvers to promote reopening of collapsed lung alveoli, prone position as rescue therapy for severe hypoxemia, and high frequency ventilation. Supportive measures in the management of ARDS include attention to fluid balance, restrictive transfusion strategies, and minimization of sedatives and neuromuscular blocking agents. Inhaled bronchodilators such as inhaled nitric oxide and prostaglandins confer short term improvement without proven effect on survival, but are currently used in many centers. Use of corticosteroids is also important, and appropriate timely use may reduce mortality. Finally, extra corporeal oxygenation methods are very useful as rescue therapy in patients with intractable hypoxemia, even though a survival benefit has not, to this date been demonstrated. Despite intense ongoing research on the pathophysiology and treatment of ARDS, mortality remains high. Many pharmacologic and supportive strategies have shown promising results, but data from large randomized clinical trials are needed to fully evaluate the true effectiveness of these therapies. KEYWORDS: ARDS; Pathophysiology; Treatment.
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Cites
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Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
Lung recruitment in patients with the acute respiratory distress syndrome.
Gattinoni, L., Caironi, P., Cressoni, M., Chiumello, D., Ranieri, V. M., Quintel, M., Russo, S., Patroniti, N., Cornejo, R., & Bugedo, G. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052052 · Cited by 1,548
Effect of prone positioning on the survival of patients with acute respiratory failure.
Gattinoni, L., Tognoni, G., Pesenti, A., Taccone, P., Mascheroni, D., Labarta, V., Malacrida, R., Di Giulio, P., Fumagalli, R., Pelosi, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010043 · Cited by 1,271
BROCHARD, L., ROUDOT-THORAVAL, F., ROUPIE, E., DELCLAUX, C., CHASTRE, J., FERNANDEZ-MONDÉJAR, E., CLÉMENTI, E., MANCEBO, J., FACTOR, P., MATAMIS, D., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9801044 · Cited by 800
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Recruitment Maneuvers for Acute Lung Injury
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“Two RCTs [57, 58] and a meta-analysis by Puntes-Arruda et al [59] showed that administration of enteral nutrition containing high concentrations of eicosapentanoic acid and γ-linoleic acid and ω-3 fatty acids increased oxygenation and decreased ICU stay and 28-day mortality in ARDS.”
BackgroundMeduri, G. U., Muthiah, M. P., Carratù, P., Eltorky, M., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000091126 · Cited by 167
Cited by
The inflammatory response in sepsis
Bosmann, M., & Ward, P. A. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.09.004 · Cited by 558
Metadata
- Authors
- Pierrakos
- Venue
- Journal of Clinical Medicine Research
- Publisher
- Elmer Press, Inc.
- Published
- 2012
- Volume
- 4
- Issue
- 1
- Pages
- 7-16
- ISSN
- 1918-3003 (ISSN-L)
- OpenAlex
- W2001899439
- Cited by
- 175
- References
- 10
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
