The fabricated collagen-based Nano-hydroxyapatite/β-tricalcium phosphate scaffolds
Open accessAbstract
The biphasic calcium phosphate (BCP) concept was introduced to overcome disadvantages of single phase biomaterials. In this study, we prepared BCP from nanoHA and β-TCP that were synthesized via a solid state reaction. Three different ratios of pure BCP and collagen-based BCP scaffolds (%HA/%β-TCP; 30/70, 40/60 and 50/50) were produced using a polymeric sponge method. Physical and mechanical properties of all materials and scaffolds were investigated. XRD pattern proved the purity of each HA, β-TCP and BCP. SEM showed overall distribution of macropores (80-200 µm) with appropriate interconnected porosities. Total porosity of pure BCP (93% ± 2) was found to be higher than collagen-based BCP (85%± 3). It was observed that dimensional shrinkage of larger scaffold (39% ± 4) is lower than smaller one (42% ± 5) and scaffolds with higher HA (50%) ratio experienced greater shrinkage than those with higher β-TCP (70%) ratio (45% ±3 and 36% ±1 respectively). Mechanical properties of both groups tend to be very low and collagen coating had no influence on mechanical behavior. Further studies may improve the physical properties of these composite BCP.
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The compressive stress of nano-HA/collagen composite is almost equal to that of bioceramics (nano-HA/β-TCP).
“Compressive stress of composite is [96] | almost equal to that of bioceramics | (nano-HA/β-TCP)”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [96]
Cites
Johnson, A. J. W., & Herschler, B. A. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.012 · Cited by 632 · see citing works
Weinreb, M., SHINAR, D. M., & Rodan, G. A. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650050806 · Cited by 438 · see citing works
Calcium orthophosphate-based biocomposites and hybrid biomaterials
Dorozhkin, S. V. (2009) · Journal of Materials Science · doi:10.1007/s10853-008-3124-x · Cited by 300 · see citing works
An improvement in sintering property of β-tricalcium phosphate by addition of calcium pyrophosphate
Ryu, H.-S., Youn, H.-J., Hong, K. S., et al. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00201-0 · Cited by 272 · see citing works
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57 · see citing works
- Authors
- Ebrahimi, M., Monmaturapoj, N., Suttapreyasri, S., & Pripatnanont, P.
- Affiliations
- Prince of Songkla University (TH)
- Thailand National Metal and Materials Technology Center (TH)
- Venue
- Advanced Materials Research
- Publisher
- Trans Tech Publications, Ltd.
- Published
- 2012-04
- Volume
- 506
- Pages
- 57-60
- ISSN
- 1022-6680 (ISSN-L)
- 1662-8985
- OpenAlex
- W2091678640
- Cited by
- 7
- References
- 4
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2019: 1 · 2012: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advanced materials research (publishedVersion, cc-by)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- biphasic calcium phosphate, hydroxyapatite nanoparticles, beta-tricalcium phosphate, collagen coating, scaffolds, solid-state synthesis, porosity, dimensional shrinkage, mechanical properties, bone tissue engineering
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