The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17
Abstract
Although IL-17-producing CD8+ T cells (Tc17 cells) have recently been identified, the detailed information about these cells still remains unclear. In this article we describe a study investigating the phenotype and differentiation of human Tc17 cells. Human Tc17 cells were detected in a minor population of CD8+ T cells and were predominantly found in CD27−/+CD28+CD45RA− memory subsets. They also expressed CCR6 and a high level of CCR5. Though most Tc17 cells produced IFN-γ, a small part of the Tc17 cell population was IFN-γ negative in some individuals. Analysis of the in vitro induction of Tc17 cells showed that these cells were induced from the CD27+CD28+CD45RA+ naive subset and that they expressed the CD27−CD28+CD45RA− and CCR6+ phenotype. These results together indicate that Tc17 cells have a unique phenotype and suggest that they differentiate from the same precursors that differentiate into IFN-γ-producing CD8+ T cells.
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Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · cited 1×
“Previous studies demonstrated that human Th17 cells are induced from precursors present among naive CD4 T cells by cell-cell contact with activated monocytes in the context of TCR ligation (19) or by stimulation with anti-CD3 and antiCD28 mAbs and then culturing them in the medium with IL1 , IL-6, IL-23, and TGF- (20).”
BackgroundSurface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“I nterleukin-17 is a group of inflammatory cytokines (1).”
BackgroundTh17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422
Volpe, E., Servant, N., Zollinger, R., Bogiatzi, S. I., Hupé, P., Barillot, E., & Soumelis, V. (2008) · Nature Immunology · doi:10.1038/ni.1613 · Cited by 938
Cited by
Interleukin-22: Immunobiology and Pathology
Dudakov, J. A., Hanash, A. M., & van den Brink, M. R. M. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112123 · Cited by 905
Inflammation, Immunity, and Hypertension
Harrison, D. G., Guzik, T. J., Lob, H. E., Madhur, M. S., Marvar, P. J., Thabet, S. R., Vinh, A., & Weyand, C. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.163576 · Cited by 871
The 3 major types of innate and adaptive cell-mediated effector immunity
Annunziato, F., Romagnani, C., & Romagnani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.001 · Cited by 818
CD161 is a marker of all human IL‐17‐producing T‐cell subsets and is induced by RORC
Maggi, L., Santarlasci, V., Capone, M., Peired, A., Frosali, F., Crome, S. Q., Querci, V., Fambrini, M., Liotta, F., Levings, M. K., et al. (2010) · European Journal of Immunology · doi:10.1002/eji.200940257 · Cited by 362
Heterogeneity in the Differentiation and Function of CD8+ T Cells
Mittrücker, H.-W., Visekruna, A., & Huber, M. (2014) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-014-0293-y · Cited by 325
Metadata
- Authors
- Kondo, T., Takata, H., Matsuki, F., & Takiguchi, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02
- Volume
- 182
- Issue
- 4
- Pages
- 1794-1798
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1577017898
- Cited by
- 170
- References
- 7
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kondo, T., Takata, H., Matsuki, F., & Takiguchi, M. (2009). Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0801347
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