The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Defective Regulatory T Cells In Patients with Severe Drug Eruptions: Timing of the Dysfunction Is Associated with the Pathological Phenotype and Outcome
Abstract
Toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) represent two ends of a spectrum of severe drug eruptions: DIHS is unique in that severe epidermal damage seen in TEN is absent, sequential reactivations of herpesviruses occur, and autoimmunity often ensues. To investigate whether changes in regulatory T (Treg) cell function would contribute to variability in the clinical manifestations, we examined the frequency, phenotype, and function of Treg cells both during the acute stage and again long after clinical resolution of both diseases. Dramatic expansions of functional Treg cells were found in the acute stage of DIHS. In contrast, Treg function was profoundly impaired in TEN, although present in normal frequency. Skin homing addressins were more preferentially expressed on Treg cells in DIHS than in TEN. Indeed, Treg cells were more abundantly present in the skin lesions of DIHS. Surprisingly, Treg cells contracted upon resolution of DIHS became functionally deficient, whereas their functional defects in TEN were restored upon recovery. These findings indicate that a transitory impairment in their function during the acute stage of TEN may be related to severe epidermal damage, while a gradual loss of their function after resolution of DIHS may increase the risk of subsequently developing autoimmune disease.
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Cites
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“Nevertheless, it was also possible that the increased frequency of Treg cells observed in DIHS merely reflects the overall status of activation of T cells, because recent studies on human Treg cells have demonstrated that TCR stimulation alone with anti-CD3 and anti-CD28 induces Foxp3 expression without acquisition of…”
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Cited by
Severe cutaneous adverse reactions to drugs
Duong, T. A., Valeyrie-Allanore, L., Wolkenstein, P., & Chosidow, O. (2017) · The Lancet · doi:10.1016/s0140-6736(16)30378-6 · Cited by 445
Praga, M., Sevillano, A., Auñón, P., & González, E. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu326 · Cited by 147
Metadata
- Authors
- Takahashi, R., Kano, Y., Yamazaki, Y., Kimishima, M., Mizukawa, Y., & Shiohara, T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06
- Volume
- 182
- Issue
- 12
- Pages
- 8071-8079
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1513629354
- Cited by
- 276
- References
- 39
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Takahashi, R., Kano, Y., Yamazaki, Y., Kimishima, M., Mizukawa, Y., & Shiohara, T. (2009). Defective Regulatory T Cells In Patients with Severe Drug Eruptions: Timing of the Dysfunction Is Associated with the Pathological Phenotype and Outcome. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0804002
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