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Cited by 276

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Defective Regulatory T Cells In Patients with Severe Drug Eruptions: Timing of the Dysfunction Is Associated with the Pathological Phenotype and Outcome

Takahashi, Ryo, Kano, Yoko, Yamazaki, Yoshimi, Kimishima, Momoko, Mizukawa, Yoshiko, Shiohara, Tetsuo·2009·The Journal of Immunology
DOI 10.4049/jimmunol.0804002
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Abstract

Toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) represent two ends of a spectrum of severe drug eruptions: DIHS is unique in that severe epidermal damage seen in TEN is absent, sequential reactivations of herpesviruses occur, and autoimmunity often ensues. To investigate whether changes in regulatory T (Treg) cell function would contribute to variability in the clinical manifestations, we examined the frequency, phenotype, and function of Treg cells both during the acute stage and again long after clinical resolution of both diseases. Dramatic expansions of functional Treg cells were found in the acute stage of DIHS. In contrast, Treg function was profoundly impaired in TEN, although present in normal frequency. Skin homing addressins were more preferentially expressed on Treg cells in DIHS than in TEN. Indeed, Treg cells were more abundantly present in the skin lesions of DIHS. Surprisingly, Treg cells contracted upon resolution of DIHS became functionally deficient, whereas their functional defects in TEN were restored upon recovery. These findings indicate that a transitory impairment in their function during the acute stage of TEN may be related to severe epidermal damage, while a gradual loss of their function after resolution of DIHS may increase the risk of subsequently developing autoimmune disease.

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Metadata

Authors
Takahashi, R., Kano, Y., Yamazaki, Y., Kimishima, M., Mizukawa, Y., & Shiohara, T.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2009-06
Volume
182
Issue
12
Pages
8071-8079
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.0804002
OpenAlex
W1513629354
Cited by
276
References
39
FWCI
8.75
Type
journal article
Language
en
Open access
closed

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