The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cutting Edge: Lung Mucosal Th17-Mediated Responses Induce Polymeric Ig Receptor Expression by the Airway Epithelium and Elevate Secretory IgA Levels
Open accessAbstract
Polymeric Ig receptor (pIgR) is a central player in mucosal immunity that mediates the delivery of polymeric IgA and IgM to the apical surface of epithelial cells via transcytosis. Emerging evidence suggests that Th17 cells not only mediate autoimmunity but also play key roles in mucosal host defense against pathogens. We demonstrate that OVA-specific CD4+ Th17 cells, in addition to causing neutrophilic inflammation in mice, mediated a pronounced influx of CD19+ B cells into the lungs following Ag inhalation. Coincident with this recruitment was a striking induction in pIgR expression by the bronchial epithelium and a subsequent increase in airway IgM and secretory IgA levels. Intranasal administration of IL-17 revealed a crucial role for this cytokine in inducing pIgR expression by the epithelium. These findings support a key role for Th17 cells in pulmonary immune defense against respiratory pathogens by promoting pIgR-mediated transport of secretory IgA and IgM into the airway.
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Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Cited by
Immunoglobulin Responses at the Mucosal Interface
Cerutti, A., Chen, K., & Chorny, A. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101317 · Cited by 395
Johansen, F.-E., & Kaetzel, C. S. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.37 · Cited by 368
The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT
Clements, J. D., & Norton, E. B. (2018) · mSphere · doi:10.1128/msphere.00215-18 · Cited by 177
Th17 cell pathogenicity in autoimmune disease
Park, E., & Ciofani, M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01535-9 · Cited by 75
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
Jie, Z., Yang, J.-Y., Gu, M., Wang, H., Xie, X., Li, Y., Liu, T., Zhu, L., Shi, J., Zhang, L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0206-z · Cited by 50
Metadata
- Authors
- Jaffar, Z., Ferrini, M. E., Herritt, L. A., & Roberts, K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04
- Volume
- 182
- Issue
- 8
- Pages
- 4507-4511
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1751404917
- Cited by
- 165
- References
- 2
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jaffar, Z., Ferrini, M. E., Herritt, L. A., & Roberts, K. (2009). Cutting Edge: Lung Mucosal Th17-Mediated Responses Induce Polymeric Ig Receptor Expression by the Airway Epithelium and Elevate Secretory IgA Levels. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0900237
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