The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Role of IL-23/IL-17 Axis in Lupus Nephritis
Open accessAbstract
T cells that express IL-17 infiltrate the kidneys of patients with systemic lupus erythematosus. A significant proportion of these cells are CD3+CD4−CD8− double-negative T cells. In this study, we show that double-negative T cells from MRL/lpr mice express high amounts of IL-17 and that as disease progressively worsens, the expression of IL-17 and of IL-23 receptor in lymphocytes from these mice increases. Lymph node cells from lupus-prone mice, but not control mice, treated in vitro with IL-23 induce nephritis when transferred to non-autoimmune, lymphocyte-deficient Rag-1−/− mice. Kidney specimens from these recipient mice show significant Ig and complement deposition. The data indicate that an aberrantly active IL-23/IL-17 axis contributes to the development of nephritis in lupus-prone mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.566 · Cited by 1,536
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · cited 2×
“This is in keeping with the finding that IL-17F plays a role in host defense, but it is not essential for disease development in a either experimental encephalomyelitis or arthritis (14).”
BackgroundResult
Cited by
CD3(+)CD4(-)CD8(-) (Double-negative) T cells in inflammation, immune disorders and cancer
Wu, Z., Zheng, Y., Sheng, J., Han, Y., Yang, Y., Pan, H., & Yao, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.816005 · Cited by 265
Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis
Pisitkun, P., Ha, H.-L., Wang, H., Claudio, E., Tivy, C. C., Zhou, H., Mayadas, T. N., Illei, G. G., & Siebenlist, U. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.014 · Cited by 174
Ramani, K., Pawaria, S., Maers, K., Huppler, A. R., Gaffen, S. L., & Biswas, P. S. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0414-184r · Cited by 48
Update on the role of Interleukin 17 in rheumatologic autoimmune diseases
Konya, C., Paz, Z., Apostolidis, S. A., & Tsokos, G. C. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.003 · Cited by 35
Self-citationInnate lymphoid cell-derived cytokines in autoimmune diseases
Li, S., Yang, D., Peng, T., Wu, Y., Tian, Z., & Ni, B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.05.001 · Cited by 19
Metadata
- Authors
- Zhang, Z., Kyttaris, V. C., & Tsokos, G. C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-01
- Volume
- 183
- Issue
- 5
- Pages
- 3160-3169
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1536123386
- Cited by
- 303
- References
- 3
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Role of IL-23/IL-17 Axis in Lupus Nephritis. https://app.cochat.ai/papers/10.4049/jimmunol.0900385
- The paper
- Zhang, Z., Kyttaris, V. C., & Tsokos, G. C. (2009). The Role of IL-23/IL-17 Axis in Lupus Nephritis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0900385
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
