The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Cell-Specific Gene Expression in Langerhans Cell Histiocytosis Lesions Reveals a Distinct Profile Compared with Epidermal Langerhans Cells
Open accessAbstract
Langerhans cell histiocytosis (LCH) is a rare disease characterized by heterogeneous lesions containing CD207+ Langerhans cells (LCs) and lymphocytes that can arise in almost any tissue and cause significant morbidity and mortality. After decades of research, the cause of LCH remains speculative. A prevailing model suggests that LCH arises from malignant transformation and metastasis of epidermal LCs. In this study, CD207+ cells and CD3+ T cells were isolated from LCH lesions to determine cell-specific gene expression. Compared with control epidermal CD207+ cells, the LCH CD207+ cells yielded 2113 differentially expressed genes (false discovery rate < 0.01). Surprisingly, the expression of many genes previously associated with LCH, including cell-cycle regulators, proinflammatory cytokines, and chemokines, were not significantly different from control LCs in our study. However, several novel genes whose products activate and recruit T cells to sites of inflammation, including SPP1 (osteopontin), were highly overexpressed in LCH CD207+ cells. Furthermore, several genes associated with immature myeloid dendritic cells were overexpressed in LCH CD207+ cells. Compared with the peripheral CD3+ cells from LCH patients, the LCH lesion CD3+ cells yielded only 162 differentially regulated genes (false discovery rate < 0.01), and the expression profile of the LCH lesion CD3+ cells was consistent with an activated regulatory T cell phenotype with increased expression of FOXP3, CTLA4, and SPP1. Results from this study support a model of LCH pathogenesis in which lesions do not arise from epidermal LCs but from accumulation of bone marrow-derived immature myeloid dendritic cells that recruit activated lymphocytes.
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Cited by
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Self-citationHistopathologic review of granulomatous inflammation
Shah, K. K., Pritt, B. S., & Alexander, M. P. (2017) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2017.02.001 · Cited by 371
Rodriguez-Galindo, C., & Allen, C. E. (2020) · Blood · doi:10.1182/blood.2019000934 · Cited by 361
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Metadata
- Authors
- Allen, C. E., Li, L., Peters, T. L., Leung, H.-C. E., Yu, A., Man, T.-K., Gurusiddappa, S., Phillips, M. T., Hicks, M. J., Gaikwad, A., Merad, M., & McClain, K. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04
- Volume
- 184
- Issue
- 8
- Pages
- 4557-4567
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2168827093
- Cited by
- 326
- References
- 50
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Allen, C. E., Li, L., Peters, T. L., Leung, H.-C. E., Yu, A., Man, T.-K., Gurusiddappa, S., Phillips, M. T., Hicks, M. J., Gaikwad, A., Merad, M., & McClain, K. L. (2010). Cell-Specific Gene Expression in Langerhans Cell Histiocytosis Lesions Reveals a Distinct Profile Compared with Epidermal Langerhans Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0902336
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