Cited by 1,382T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisFOXO transcription factor regulation

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Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

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Thornton, Angela M, Korty, Patricia E, Tran, Dat Q, Wohlfert, Elizabeth A, Murray, Patrick E, Belkaid, Yasmine, Shevach, Ethan M·2010·The Journal of Immunology

DOI 10.4049/jimmunol.0904028PMC PMC3725574

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Abstract

Helios, a member of the Ikaros transcription factor family, is preferentially expressed at the mRNA level by regulatory T cells (Treg cells). We evaluated Helios protein expression using a newly generated mAb and demonstrated that it is expressed in all thymocytes at the double negative 2 stage of thymic development. Although Helios was expressed by 100% of CD4+CD8−Foxp3+ thymocytes, its expression in peripheral lymphoid tissues was restricted to a subpopulation (∼70%) of Foxp3+ T cells in mice and humans. Neither mouse nor human naive T cells induced to express Foxp3 in vitro by TCR stimulation in the presence of TGF-β expressed Helios. Ag-specific Foxp3+ T cells induced in vivo by Ag feeding also failed to express Helios. Collectively, these results demonstrate that Helios is potentially a specific marker of thymic-derived Treg cells and raises the possibility that a significant percentage of Foxp3+ Treg cells are generated extrathymically.

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Authors: Thornton, A. M., Korty, P. E., Tran, D. Q., Wohlfert, E. A., Murray, P. E., Belkaid, Y., & Shevach, E. M.
Affiliations: National Institutes of Health (US)
Laboratory of Immunology
ORCID: Thornton, Angela M
Tran, Dat Q
Wohlfert, Elizabeth A
Belkaid, Yasmine
Shevach, Ethan M
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2010-04-01
Volume: 184
Issue: 7
Pages: 3433-3441
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.0904028
PMC: PMC3725574
OpenAlex: W2111329034
Cited by: 1,382
References: 47
Citations by year: 2026: 44 · 2025: 55 · 2024: 63 · 2023: 50 · 2022: 70 · 2021: 57 · 2020: 70 · 2019: 84 · 2018: 82 · 2017: 74 · 2016: 97 · 2015: 119 · 2014: 110 · 2013: 144 · 2012: 129
FWCI: 55.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
Keywords: Helios, Foxp3+ regulatory T cells, T cell development, double-negative thymocytes, TGF-beta
MeSH terms: Animals, Cell Differentiation, Cell Separation, DNA-Binding Proteins, Female, Flow Cytometry, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Spleen, Thymus Gland, Transcription Factors, T-Lymphocyte Subsets, Cell Lineage, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocytes, Regulatory, Mice, Ikaros Transcription Factor, Forkhead Transcription Factors

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Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

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