Flagellin as an Adjuvant: Cellular Mechanisms and Potential

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3. A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations
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4. An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non‐human primate neonates
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6. Protective Humoral Immunity Elicited by a Needle-Free Malaria Vaccine Comprised of a Chimeric Plasmodium falciparum Circumsporozoite Protein and a Toll-Like Receptor 5 Agonist, Flagellin
   Daniel Carapau, Robert A. Mitchell, Adéla Nacer, Alan R. SHAW, Caroline Othoro, Ute Frevert, Elizabeth Higgins Nardin · 2013 · Infection and Immunity
7. Immunization of chicken with flagellin adjuvanted Salmonella enteritidis bacterial ghosts confers complete protection against chicken salmonellosis
   Amal Senevirathne, Chamith Hewawaduge, John Hwa Lee · 2021 · Poultry Science
8. A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications
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9. Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs
   Yinglin Qi, Hongtao Kang, Xuexing Zheng, Hualei Wang, Yuwei Gao, Songtao Yang, Xianzhu Xia · 2015 · Frontiers in Microbiology
10. VHSV G glycoprotein major determinants implicated in triggering the host type I IFN antiviral response as DNA vaccine molecular adjuvants
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11. Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods
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12. Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract
    Delphine Fougeron, Laurye Van Maele, Pascal Songhet, Delphine Cayet, David Hot, Nico van Rooijen, Hans‐Joachim Mollenkopf, Wolf‐Dietrich Hardt, Arndt Benecke, Jean‐Claude Sirard · 2015 · Vaccine
13. Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity, reduced allergenicity, and intrinsic adjuvanticity
    Claudia Kitzmüller, Julia Kalser, Sonja Mutschlechner, Michael Hauser, Gerhard J. Zlabinger, Fátima Ferreira, Barbara Bohle · 2017 · Journal of Allergy and Clinical Immunology
14. Flagellin attenuates experimental sepsis in a macrophage-dependent manner
    Xiaoliang Yang, Yibing Yin, Xingxing Yan, Zebo Yu, Yi Liu, Ju Cao · 2019 · Critical Care
15. A Highly Sensitive Cell-Based TLR Reporter Platform for the Specific Detection of Bacterial TLR Ligands
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16. Overview of the recent advances in porcine epidemic diarrhea vaccines
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17. Transcriptome Sequencing Investigated the Tumor-Related Factors Changes After T. gondii Infection
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18. Constructing conjugate vaccine against Salmonella Typhimurium using lipid-A free lipopolysaccharide
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19. Flagellin/Virus-like Particle Hybrid Platform with High Immunogenicity, Safety, and Versatility for Vaccine Development
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20. Use of recombinant flagellin in oil-in-water emulsions enhances hemagglutinin-specific mucosal IgA production and IL-17 secreting T cells against H5N1 avian influenza virus infection
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21. Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin
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22. Effects of recombinant flagellin B and its ND1 domain from Vibrio anguillarum on macrophages from gilthead seabream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss, W.)
    Roxana González‐Stegmaier, Alex Romero, A. Estepa, Jana Montero, Víctoriano Mulero, Luis A. Mercado · 2014 · Fish & Shellfish Immunology
23. Incorporation of membrane-anchored flagellin into Salmonella Gallinarum bacterial ghosts induces early immune responses and protection against fowl typhoid in young layer chickens
    Irshad Ahmed Hajam, Kim Je Hyoung, John Hwa Lee · 2018 · Veterinary Immunology and Immunopathology
24. A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen
    Neal Van Hoeven, Steven R. Wiley, Emily Gage, Andrew J. Fiore-Gartland, Brian Granger, Sean A. Gray, Christopher B. Fox, David E. Clements, D E Parks, Scott B. Winram et al. · 2018 · npj Vaccines
25. Salmonella flagellin is a potent carrier–adjuvant for peptide conjugate to induce peptide-specific antibody response in mice
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26. Chicken Immune Response after In Ovo Immunization with Chimeric TLR5 Activating Flagellin of Campylobacter jejuni
    Katarzyna A. Radomska, Mahdi M. Vaezirad, Koen M. H. W. Verstappen, Marc M. S. M. Wösten, Jaap A. Wagenaar, Jos P. M. van Putten · 2016 · PLoS ONE
27. Adjuvants and Delivery Methods: Current and Novel
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28. Flagellin: a unique microbe-associated molecular pattern and a multi-faceted immunomodulator
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29. Immunogenicity Associated with Aesthetic Botulinumtoxin A: A Survey of Asia-Pacific Physicians’ Experiences and Recommendations
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30. Efficacy of Soluble Recombinant FliC Protein from Salmonella enterica Serovar Enteritidis as a Potential Vaccine Candidate Against Homologous Challenge in Chickens
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31. Enhancement of Host Immune Responses by Oral Vaccination to Salmonella enterica serovar Typhimurium Harboring Both FliC and FljB Flagella
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32. Amino acids 89–96 of Salmonella typhimurium flagellin represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response
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33. Induction of IFN-γ cytokine response against hepatitis B surface antigen using melittin.
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34. Dengue and Zika Virus Domain III-Flagellin Fusion and Glycan-Masking E Antigen for Prime-Boost Immunization
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35. Improving immunogenicity and safety of flagellin as vaccine carrier by high-density display on virus-like particle surface
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36. High mobility group box 1 acts as an adjuvant for tuberculosis subunit vaccines
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37. Toll-like receptor 5 gene polymorphism is associated with breast cancer susceptibility
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38. Immunogenicity of Recombinant Proteins Consisting of Plasmodium vivax Circumsporozoite Protein Allelic Variant-Derived Epitopes Fused with Salmonella enterica Serovar Typhimurium Flagellin
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40. Helicobacter pylori flagellin: TLR5 evasion and fusion-based conversion into a TLR5 agonist
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41. Efficacy of chitosan-based nanoparticle vaccine administered to broiler birds challenged with Salmonella
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42. Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC
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43. Adjuvants in Fish Vaccines
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44. Toward innovative veterinary nanoparticle vaccines
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45. Immunity Elicited by an Experimental Vaccine Based on Recombinant Flagellin-Porcine Circovirus Type 2 Cap Fusion Protein in Piglets
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46. Host‐ and pathogen‐derived adjuvant coatings on protein nanoparticle vaccines
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47. N-terminus of Flagellin Fused to an Antigen Improves Vaccine Efficacy against Pasteurella Multocida Infection in Chickens
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48. Skin Vaccination with Dissolvable Microneedle Patches Incorporating Influenza Neuraminidase and Flagellin Protein Nanoparticles Induces Broad Immune Protection against Multiple Influenza Viruses
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49. Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model
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50. Using Immunoinformatics and Structural Approaches to Design a Novel HHV8 Vaccine
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51. Developing inexpensive malaria vaccines from plants and algae
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52. Full recombinant flagellin B from Vibrio anguillarum (rFLA) and its recombinant D1 domain (rND1) promote a pro-inflammatory state and improve vaccination against P. salmonis in Atlantic salmon (S. salar)
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53. Clinical Improvement After Treatment With IncobotulinumtoxinA (XEOMIN®) in Patients With Cervical Dystonia Resistant to Botulinum Toxin Preparations Containing Complexing Proteins
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54. TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium
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55. Expression of recombinant Newcastle disease virus F protein in Pichia pastoris and its immunogenicity using flagellin as the adjuvant
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57. Pseudomonas aeruginosa flagellin as an adjuvant: superiority of a conjugated form of flagellin versus a mixture with a human immunodeficiency virus type 1 vaccine candidate in the induction of immune responses
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58. Immunization of Broiler Chickens With a Killed Chitosan Nanoparticle Salmonella Vaccine Decreases Salmonella Enterica Serovar Enteritidis Load
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59. Rapid CD4+ T‐cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9
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60. Advantages and Limitations of Integrated Flagellin Adjuvants for HIV-Based Nanoparticle B-Cell Vaccines
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61. Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity
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62. Preparation of Pseudomonas aeruginosa alginate-flagellin immunoconjugate
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64. Innate immune responses to Proteus mirabilis flagellin in the urinary tract
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68. Expression of a hepatitis A virus antigen in Lactococcus lactis and Escherichia coli and evaluation of its immunogenicity
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69. Flagellin Encoded in Gene-Based Vector Vaccines Is a Route-Dependent Immune Adjuvant
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71. Nonconservation of TLR5 activation site in Edwardsiella tarda flagellin decreases expression of interleukin-1β and NF-κB genes in Japanese flounder, Paralichthys olivaceus
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72. FliC’s Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses
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79. NLRC4 Inflammasome-Driven Immunogenicity of a Recombinant MVA Mucosal Vaccine Encoding Flagellin
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80. Flagellar regulation mediated by the Rcs pathway is required for virulence in the fish pathogen Yersinia ruckeri
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81. Parenteral immunization of Salmonella Typhimurium ghosts with surface-displayed Escherichia coli flagellin enhancesTLR-5 mediated activation of immune responses that protect the chicken against Salmonella infection
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90. Flagellin-rPAc vaccine inhibits biofilm formation but not proliferation ofS. mutans
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91. Neutrophils and IL17A mediate flagellar hook protein FlgE-induced mouse acute lung inflammation
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92. A rationally designed flagellin-L2 fusion protein induced serum and mucosal neutralizing antibodies against multiple HPV types
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93. The N‐terminal D1 domain of Treponema pallidum flagellin binding to TLR5 is required but not sufficient in activation of TLR5
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95. The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon
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96. Evaluation of immunogenicity and protective effect of DNA vaccine encoding surface antigen1 (SAG1) of Toxoplasma gondii and TLR-5 ligand as a genetic adjuvant against acute toxoplasmosis in BALB/c mice
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97. Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate
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98. Immunizing Adult Female Mice with a TcpA-A2-CTB Chimera Provides a High Level of Protection for Their Pups in the Infant Mouse Model of Cholera
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