Flagellin as an Adjuvant: Cellular Mechanisms and Potential

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131 · see citing works

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works

Control of B-cell responses by Toll-like receptors

Pasare, C., & Medzhitov, R. M. (2005) · Nature · doi:10.1038/nature04267 · Cited by 752 · see citing works

The Conduit System Transports Soluble Antigens from the Afferent Lymph to Resident Dendritic Cells in the T Cell Area of the Lymph Node

Sixt, M., Kanazawa, N., Selg, M., Samson, T., Roos, G., Reinhardt, D. P., Pabst, R., Lutz, M. B., & Sorokin, L. M. (2005) · Immunity · doi:10.1016/j.immuni.2004.11.013 · Cited by 749 · see citing works

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

Uematsu, S., Fujimoto, K., Jang, M. H., Yang, B., Jung, Y.-J., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., et al. (2008) · Nature Immunology · doi:10.1038/ni.1622 · Cited by 746 · see citing works

Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos

Agrawal, S., Agrawal, A., Doughty, B. L., Gerwitz, A., Blenis, J., Dyke, T. E. V., & Pulendran, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4984 · Cited by 726 · see citing works

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

Lightfield, K. L., Persson, J., Brubaker, S. W., Witte, C. E., von Moltke, J., Dunipace, E. A., Henry, T., Sun, Y., Cado, D., Dietrich, W. F., et al. (2008) · Nature Immunology · doi:10.1038/ni.1646 · Cited by 487 · see citing works

The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells

Means, T. K., Hayashi, F., Smith, K. D., Aderem, A. A., & Luster, A. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5165 · Cited by 411 · see citing works

Direct Stimulation of Human T Cells via TLR5 and TLR7/8: Flagellin and R-848 Up-Regulate Proliferation and IFN-γ Production by Memory CD4+ T Cells

Caron, G., Duluc, D., Frémaux, I., Jeannin, P., David, C., Gascan, H., & Delneste, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1551 · Cited by 410 · see citing works

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

Huleatt, J. W., Nakaar, V., Desai, P., Huang, Y., Hewitt, D., Jacobs, A., Tang, J. T., McDonald, W. F., Song, L., Evans, R. K., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.10.062 · Cited by 382 · see citing works

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

Crellin, N. K., García, R., Hadisfar, O., Allan, S., Steiner, T. S., & Levings, M. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8051 · Cited by 375 · see citing works

Flagellin Promotes Myeloid Differentiation Factor 88-Dependent Development of Th2-Type Response

Didierlaurent, A. M., Ferrero, I., Otten, L., Dubois, B., Reinhardt, M., Carlsen, H., Blomhoff, R., Akira, S., Kraehenbühl, J.-P., & Sirard, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6922 · Cited by 310 · see citing works

Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity

Huleatt, J. W., Jacobs, A. R., Tang, J. T., Desai, P., Kopp, E. B., Huang, Y., Song, L., Nakaar, V., & Powell, T. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.08.013 · Cited by 300 · see citing works

A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

Datta, S. K., Redecke, V., Prilliman, K. R., Takabayashi, K., Corr, M., Tallant, T. C., DiDonato, J. A., Dziarski, R., Akira, S., Schoenberger, S. P., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4102 · Cited by 300 · see citing works

Flagellin Is an Effective Adjuvant for Immunization against Lethal Respiratory Challenge withYersinia pestis

Honko, A. N., Sriranganathan, N., Lees, C. J., & Mizel, S. B. (2006) · Infection and Immunity · doi:10.1128/iai.74.2.1113-1120.2006 · Cited by 279 · see citing works

Characterization of CD4+ T Cell Responses During Natural Infection with Salmonella typhimurium

McSorley, S. J., Cookson, B. T., & Jenkins, M. K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.986 · Cited by 239 · see citing works

A Bacterial Flagellin, Vibrio vulnificus FlaB, Has a Strong Mucosal Adjuvant Activity To Induce Protective Immunity

Lee, S. E., Kim, S. Y., Jeong, B. C., Kim, Y. R., Bae, S. J., Ahn, O. S., Lee, J., Song, H.-C., Kim, J. M., Choy, H. E., et al. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.694-702.2006 · Cited by 226 · see citing works

Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses

Cuadros, C., López-Hernández, F. J., Dominguez, A. L., McClelland, M., & Lustgarten, J. (2004) · Infection and Immunity · doi:10.1128/iai.72.5.2810-2816.2004 · Cited by 188 · see citing works

A West Nile Virus Recombinant Protein Vaccine That Coactivates Innate and Adaptive Immunity

McDonald, W. F., Huleatt, J. W., Foellmer, H. G., Hewitt, D., Tang, J. T., Desai, P., Price, A., Jacobs, A., Takahashi, V., Huang, Y., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/517613 · Cited by 185 · see citing works

Effects of Flagellin on Innate and Adaptive Immunity

Honko, A. N., & Mizel, S. B. (2005) · Immunologic Research · doi:10.1385/ir:33:1:083 · Cited by 171 · see citing works

High-Affinity Interaction between Gram-Negative Flagellin and a Cell Surface Polypeptide Results in Human Monocyte Activation

McDermott, P. F., Ciacci-Woolwine, F., Snipes, J. A., & Mizel, S. B. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5525-5529.2000 · Cited by 161 · see citing works

Role of Toll‐like receptors in costimulating cytotoxic T cell responses

Schwarz, K., Storni, T., Manolova, V., Didierlaurent, A. M., Sirard, J., Röthlisberger, P., & Bachmann, M. F. (2003) · European Journal of Immunology · doi:10.1002/eji.200323919 · Cited by 155 · see citing works

SalmonellaFlagellin Induces Tumor Necrosis Factor Alpha in a Human Promonocytic Cell Line

Ciacci-Woolwine, F., Blomfield, I. C., Richardson, S. H., & Mizel, S. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1127-1134.1998 · Cited by 154 · see citing works

Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative Flagellin

Mizel, S. B., West, A. P., & Hantgan, R. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303481200 · Cited by 153 · see citing works

Two Nonadjacent Regions in Enteroaggregative Escherichia coli Flagellin Are Required for Activation of Toll-like Receptor 5

Donnelly, M. A., & Steiner, T. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206851200 · Cited by 144 · see citing works

Salmonella Flagellin-Dependent Proinflammatory Responses Are Localized to the Conserved Amino and Carboxyl Regions of the Protein

Eaves-Pyles, T. D., Wong, H. R., Odoms, K., & Pyles, R. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.7009 · Cited by 141 · see citing works

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

Wang, B., Quan, F., Kang, S., Bozja, J., Skountzou, I., & Compans, R. W. (2008) · Journal of Virology · doi:10.1128/jvi.01076-08 · Cited by 138 · see citing works

Flagellin-F1-V Fusion Protein Is an Effective Plague Vaccine in Mice and Two Species of Nonhuman Primates

Mizel, S. B., Graff, A. H., Sriranganathan, N., Ervin, S. E., Lees, C. J., Lively, M. O., Hantgan, R. R., Thomas, M. J., Wood, J. F., & Bell, B. A. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00333-08 · Cited by 137 · see citing works

Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1

Cunningham, A. F., Khan, M., Ball, J., Toellner, K., Serre, K., Mohr, E., & MacLennan, I. C. M. (2004) · European Journal of Immunology · doi:10.1002/eji.200425403 · Cited by 134 · see citing works

New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin

Bargieri, D. Y., Rosa, D. S., Braga, C. J. M., Carvalho, B. O., Costa, F. T. M., Espíndola, N. M., Vaz, A. J., Soares, I. S., Ferreira, L. C. D. S., & Rodrigues, M. M. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.08.070 · Cited by 132 · see citing works

Identification of Conserved Domains in Salmonella muenchen Flagellin That Are Essential for Its Ability to Activate TLR5 and to Induce an Inflammatory Response in Vitro

Murthy, K. G. K., Deb, A., Goonesekera, S. D., Szabó, C., & Salzman, A. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307759200 · Cited by 128 · see citing works

Mucosal Administration of Flagellin Induces Innate Immunity in the Mouse Lung

Honko, A. N., & Mizel, S. B. (2004) · Infection and Immunity · doi:10.1128/iai.72.11.6676-6679.2004 · Cited by 125 · see citing works

Gram-negative Flagellin-induced Self-tolerance Is Associated with a Block in Interleukin-1 Receptor-associated Kinase Release from Toll-like Receptor 5

Mizel, S. B., & Snipes, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201762200 · Cited by 123 · see citing works

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

Pegu, A., Qin, S., Junecko, B. A. F., Nisato, R. E., Pepper, M. S., & Reinhart, T. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3399 · Cited by 120 · see citing works

Humoral Immune Response to Flagellin Requires T Cells and Activation of Innate Immunity

Sanders, C. J., Yu, Y., Moore, D. A., Williams, I. R., & Gewirtz, A. T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2810 · Cited by 117 · see citing works

Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination

Salman, H. H., Irache, J. M., & Gamazo, C. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.091 · Cited by 107 · see citing works

Evaluation of a Truncated Recombinant Flagellin Subunit Vaccine against Campylobacter jejuni

Lee, L. H., Burg, E. F., Baqar, S., Bourgeois, A. L., Burr, D. H., Ewing, C. P., Trevor J. TRUST, & Guerry, P. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.5799-5805.1999 · Cited by 97 · see citing works

Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice

Strindelius, L., Filler, M., & Sjöholm, I. (2004) · Vaccine · doi:10.1016/j.vaccine.2003.12.035 · Cited by 97 · see citing works

A universal epitope-based influenza vaccine and its efficacy against H5N1

Adar, Y., Singer, Y., Levi, R., Tzehoval, E., Perk, S., Banet-Noach, C., Nagar, S., Arnon, R., & Ben-Yedidia, T. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.02.011 · Cited by 97 · see citing works

Immunosenescence and Influenza Vaccine Efficacy

Sambhara, S. R., & McElhaney, J. E. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-92165-3_20 · Cited by 96 · see citing works

Activation of Interleukin-1 Receptor-Associated Kinase by Gram-Negative Flagellin

Moors, M. A., Li, L., & Mizel, S. B. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4424-4429.2001 · Cited by 92 · see citing works

Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin

Song, L., Zhang, Y., Yun, N. E., Poussard, A. L., Smith, J. N., Smith, J. K., Borisevich, V., Linde, J., Zacks, M. A., Li, H., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.07.060 · Cited by 92 · see citing works

Synthetic recombinant vaccine expressing influenza haemagglutinin epitope in Salmonella flagellin leads to partial protection in mice

McEwen, J. G., Levi, R., Horwitz, R. J., & Arnon, R. (1992) · Vaccine · doi:10.1016/0264-410x(92)90071-q · Cited by 92 · see citing works

Synthetic recombinant influenza vaccine induces efficient long-term immunity and cross-strain protection

Levi, R. (1996) · Vaccine · doi:10.1016/0264-410x(95)00088-i · Cited by 90 · see citing works

A Fusion Protein Vaccine Containing OprF Epitope 8, OprI, and Type A and B Flagellins Promotes Enhanced Clearance of Nonmucoid Pseudomonas aeruginosa

Weimer, E. T., Lu, H., Kock, N. D., Wozniak, D. J., & Mizel, S. B. (2009) · Infection and Immunity · doi:10.1128/iai.00054-09 · Cited by 87 · see citing works

Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions

Tsujimoto, H., Uchida, T., Efron, P. A., Scumpia, P. O., Verma, A., Matsumoto, T., Tschoeke, S. K., Ungaro, R. F., Ono, S., Seki, S., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0105051 · Cited by 87 · see citing works

Direct Stimulation of tlr5+/+ CD11c+ Cells Is Necessary for the Adjuvant Activity of Flagellin

Bates, J. T., Uematsu, S., Akira, S., & Mizel, S. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804225 · Cited by 86 · see citing works

Human Intestinal Microvascular Endothelial Cells Express Toll-Like Receptor 5: A Binding Partner for Bacterial Flagellin

Maaser, C., Heidemann, J., von Eiff, C., Lügering, A., Spahn, T. W., Binion, D. G., Domschke, W., Lügering, N., & Kucharzik, T. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.5056 · Cited by 85 · see citing works

Activated Human Neonatal CD8+ T Cells Are Subject to Immunomodulation by Direct TLR2 or TLR5 Stimulation

McCarron, M. J., & Reen, D. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.55 · Cited by 79 · see citing works

Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors

Benkő, S., Magyarics, Z., Szabó, A., & Rajnavölgyi, É. (2008) · Biological Chemistry · doi:10.1515/bc.2008.054 · Cited by 66 · see citing works

Immunization of young African green monkeys with OprF epitope 8–OprI–type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonasaeruginosa

Weimer, E. T., Ervin, S. E., Wozniak, D. J., & Mizel, S. B. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.08.080 · Cited by 65 · see citing works

Intranasal immunization with synthetic recombinant vaccine containing multiple epitopes of influenza virus

Jeon, S. H., Ben-Yedidia, T., & Arnon, R. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00187-1 · Cited by 64 · see citing works

Salmonella Flagellin Induces Bystander Activation of Splenic Dendritic Cells and Hinders Bacterial Replication In Vivo

Salazar-Gonzalez, R.-M., Srinivasan, A., Griffin, A., Muralimohan, G., Ertelt, J. M., Ravindran, R., Vella, A. T., & McSorley, S. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6169 · Cited by 64 · see citing works

Mucosal adjuvant activity of flagellin in aged mice

Bates, J. T., Honko, A. N., Graff, A. H., Kock, N. D., & Mizel, S. B. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.01.009 · Cited by 63 · see citing works

Effect of pre-existing carrier immunity on the efficacy of synthetic influenza vaccine

Ben-Yedidia, T., & Arnon, R. (1998) · Immunology Letters · doi:10.1016/s0165-2478(98)00073-x · Cited by 60 · see citing works

Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection

Ben-Yedidia, T., Marcus, H., Reisner, Y., & Arnon, R. (1999) · International Immunology · doi:10.1093/intimm/11.7.1043 · Cited by 60 · see citing works

A Recombinant Flagellin-Poxvirus Fusion Protein Vaccine Elicits Complement-Dependent Protection Against Respiratory Challenge with Vaccinia Virus in Mice

Delaney, K. N., Phipps, J. P., Johnson, J. B., & Mizel, S. B. (2010) · Viral Immunology · doi:10.1089/vim.2009.0107 · Cited by 59 · see citing works

CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein

Braga, C. J. M., Massis, L. M., Sbrogio-Almeida, M. E., de Alencar, B. C., Bargieri, D. Y., Boscardin, S. B., Rodrigues, M. M., & Ferreira, L. C. D. S. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.11.003 · Cited by 56 · see citing works

Cellular Mechanisms of the Adjuvant Activity of the Flagellin Component FljB ofSalmonella entericaSerovar Typhimurium To Potentiate Mucosal and Systemic Responses

Pino, O., Martin, M., & Michalek, S. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6763-6770.2005 · Cited by 56 · see citing works

TLR5 ligation by flagellin converts tolerogenic dendritic cells into activating antigen-presenting cells that preferentially induce T-helper 1 responses

Vicente-Suarez, I., Brayer, J. B., Villagra, A., Cheng, F., & Sotomayor, E. M. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.06.007 · Cited by 55 · see citing works

Induction of Cytokine Synthesis by Flagella from Gram-Negative Bacteria May Be Dependent on the Activation or Differentiation State of Human Monocytes

Ciacci-Woolwine, F., McDermott, P. F., & Mizel, S. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.10.5176-5185.1999 · Cited by 55 · see citing works

Both Radioresistant and Hemopoietic Cells Promote Innate and Adaptive Immune Responses to Flagellin

Sanders, C. J., Moore, D. A., Williams, I. R., & Gewirtz, A. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7184 · Cited by 53 · see citing works

Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella Typhimurium

Bargieri, D. Y., Leite, J. A., Lopes, S. C. P., Sbrogio-Almeida, M. E., Braga, C. J. M., Ferreira, L. C. D. S., Soares, I. S., Costa, F. T. M., & Rodrigues, M. M. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.004 · Cited by 49 · see citing works

Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection bySchistosoma mansoni

Ben-Yedidia, T., Tarrab-Hazdai, R., Schechtman, D., & Arnon, R. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4360-4366.1999 · Cited by 42 · see citing works

Efficacy of anti-influenza peptide vaccine in aged mice

Ben-Yedidia, T., Abel, L., Arnon, R., & Globerson, A. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00045-1 · Cited by 41 · see citing works

Gangliosides Inhibit Flagellin Signaling in the Absence of an Effect on Flagellin Binding to Toll-like Receptor 5

West, A. P., Dancho, B. A., & Mizel, S. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411875200 · Cited by 39 · see citing works

Inhibition of Airway Allergic Disease by Co-Administration of Flagellin with Allergen

Lee, S. E., Koh, Y., Kim, M.-K., Kim, Y. R., Kim, S. Y., Nam, J. H., Choi, Y. D., Bae, S. J., Ko, Y. J., Ryu, H.-J., et al. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9138-3 · Cited by 33 · see citing works

Antibody response against Escherichia coli heat-stable enterotoxin expressed as fusions to flagellin

Pereira, C. M., Guth, B. E. C., Sbrogio-Almeida, M. E., & Castilho, B. A. (2001) · Microbiology · doi:10.1099/00221287-147-4-861 · Cited by 32 · see citing works

Bacterial flagellin inhibits T cell receptor-mediated activation of T cells by inducing suppressor of cytokine signalling-1 (SOCS-1)

Okugawa, S., Yanagimoto, S., Tsukada, K., Kitazawa, T., Koike, K., Kimura, S., Nagase, H., Hirai, K., & Ota, Y. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00731.x · Cited by 27 · see citing works

Engineered Expression of the TLR5 Ligand Flagellin Enhances Paramyxovirus Activation of Human Dendritic Cell Function

Arimilli, S., Johnson, J. B., Clark, K. M., Graff, A. H., Alexander‐Miller, M. A., Mizel, S. B., & Parks, G. D. (2008) · Journal of Virology · doi:10.1128/jvi.01288-08 · Cited by 24 · see citing works

Stimulation of Human CD4+ T Lymphocytes via TLR3, TLR5 and TLR7/8 Up-Regulates Expression of Costimulatory and Modulates Proliferation

Simone, R., Floriani, A., & Saverino, D. (2009) · The Open Microbiology Journal · doi:10.2174/1874285800903010001 · Cited by 18 · see citing works

Immunogenicity of cholera toxin B epitope inserted in Salmonella flagellin expressed on bacteria and administered as DNA vaccine

Chauhan, N., Kumar, R., Badhai, J., Preet, A., & Yadava, P. K. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-2240-z · Cited by 15 · see citing works

IgA response of BALB/c mice to orally administered Salmonella typhimurium flagellin‐displaying T2 bacteriophages

Synnott, A. J., Ohshima, K., Nakai, Y., & Tanji, Y. (2009) · Biotechnology Progress · doi:10.1002/btpr.132 · Cited by 11 · see citing works

flagellin fused with a linear epitope of colonization factor antigen I (CFA/I) can prime antibody responses against homologous and heterologous fimbriae of enterotoxigenic

de Luna, M. D. G., Sardella, F. F., & Ferreira, L. C. D. S. (2000) · Research in Microbiology · doi:10.1016/s0923-2508(00)00227-8 · Cited by 9 · see citing works

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works

Modern Subunit Vaccines: Development, Components, and Research Opportunities

Moyle, P. M., & Tóth, I. (2013) · ChemMedChem · doi:10.1002/cmdc.201200487 · Cited by 464 · see citing works

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works

Bacterial flagellin—a potent immunomodulatory agent

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Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs

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A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

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