Lack of Th17 Cell Generation in Patients with Severe Burn Injuries

Inatsu, Akihito; Kogiso, Mari; Jeschke, Marc G; Asai, Akira; Kobayashi, Makiko; Herndon, David N; Suzuki, Fujio

doi:10.4049/jimmunol.1003235

Cited by 34Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyBurn Injury Management and Outcomes

Lack of Th17 Cell Generation in Patients with Severe Burn Injuries

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Inatsu, Akihito, Kogiso, Mari, Jeschke, Marc G, Asai, Akira, Kobayashi, Makiko, Herndon, David N, Suzuki, Fujio·2011·The Journal of Immunology

DOI 10.4049/jimmunol.1003235PMC PMC3787521

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Abstract

Immunodeficient patients with severe burn injuries are extremely susceptible to infection with Candida albicans. In addition to Th1 cells, IL-17–producing CD4+ T cells (Th17 cells) have recently been described as an important effector cell in host anti-Candida resistance. In this study, therefore, we tried to induce Th17 cells in cultures of severely burned patient PBMC by stimulation with the C. albicans Ag (CAg). In the results, the biomarkers for Th17 cells (IL-17 production and intracellular expression of IL-17 and retinoic acid receptor-related orphan receptor γt) were not displayed by burn patient PBMC stimulated with CAg, whereas these biomarkers of Th17 cells were detected in cultures of healthy donor PBMC stimulated with CAg. Burn patient sera were shown to be inhibitory on CAg-stimulated Th17 cell generation in healthy donor PBMC cultures; however, Th17 cells were induced by CAg in healthy donor PBMC cultures supplemented with burn patient sera that were previously treated with anti–IL-10 mAb. Also, the biomarkers of Th17 cells were not induced by CAg in healthy donor PBMC cultures supplemented with rIL-10. IL-10 was detected in serum specimens derived from severely burned patients. These results indicate that Th17 cells are not generated in burn patient PBMC cultures supplemented with CAg. IL-10, produced in response to burn injuries, is shown to be inhibitory on Th17 cell generation. The high susceptibility of severely burned patients to C. albicans infection might be influenced if burn-associated IL-10 production is intervened.

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IL-17A is decreased at wound sites in severe burn wound patients who are highly susceptible to infections and sepsis.
“IL-17A is decreased at wound sites in severe burn wound patients who are highly susceptible to infections and sepsis.77”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [77]

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IL-10 desensitizes Th17 cells memorized with Candida antigen (34.9)
Inatsu, A., Jeschke, M. G., Yoshida, S., Asai, A., Kobayashi, M., Herndon, D. N., & Suzuki, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.34.9
Self-citation
Severe burn injury leads to spontaneous generation of Th17 CD4+ T cells in wound draining lymph nodes (42.18)
Neely, C. J., Maile, R., Wang, M.-J., Wolfgang, M. C., & Cairns, B. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.42.18
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Burn-associated Candida albicans infection caused by CD30+ type 2 T cells
Kobayashi, M., Kobayashi, H., Herndon, D. N., Pollard, R. B., & Suzuki, F. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.6.723 · Cited by 40 · see citing works
Self-citation
Burn induces a Th-17 inflammatory response at the injury site
Sasaki, J. R., Zhang, Q., & Schwacha, M. G. (2011) · Burns · doi:10.1016/j.burns.2011.01.028 · Cited by 48 · see citing works

Authors: Inatsu, A., Kogiso, M., Jeschke, M. G., Asai, A., Kobayashi, M., Herndon, D. N., & Suzuki, F.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Shriners Hospitals for Children - Galveston (US)
Corresponding author: Suzuki, Fujio
ORCID: Jeschke, Marc G
Asai, Akira
Kobayashi, Makiko
Herndon, David N
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2011-09-01
Volume: 187
Issue: 5
Pages: 2155-2161
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.1003235
PMC: PMC3787521
OpenAlex: W1654130958
Cited by: 34
References: 47
Citations by year: 2025: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 4
FWCI: 1.84
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (P50GM060338)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
Keywords: Th17 cells, severe burns, Candida albicans infection, IL-10, immunosuppression, CD4+ T cells, IL-17, Candida albicans antigen, anti-IL-10 antibody, fungal infection susceptibility
MeSH terms: Adult, Burns, Cells, Cultured, Child, Female, Humans, Male, Mycoses, Interleukin-10, Th17 Cells

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Lack of Th17 Cell Generation in Patients with Severe Burn Injuries

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