Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Open accessAbstract
Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We also found a decrease in resident microglia in the spinal cord with disease progression. Prior to disease onset, splenic Ly6Chi monocytes expressed a polarized macrophage phenotype (M1 signature), which included increased levels of chemokine receptor CCR2. As disease onset neared, microglia expressed increased CCL2 and other chemotaxis-associated molecules, which led to the recruitment of monocytes to the CNS by spinal cord-derived microglia. Treatment with anti-Ly6C mAb modulated the Ly6Chi monocyte cytokine profile, reduced monocyte recruitment to the spinal cord, diminished neuronal loss, and extended survival. In humans with ALS, the analogous monocytes (CD14+CD16-) exhibited an ALS-specific microRNA inflammatory signature similar to that observed in the ALS mouse model, linking the animal model and the human disease. Thus, the profile of monocytes in ALS patients may serve as a biomarker for disease stage or progression. Our results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peripheral macrophages that infiltrate motor axons during amyotrophic lateral sclerosis progression may also be neurotoxic.
“peripheral macrophages that infiltrate motor axons during disease progression may also be neurotoxic (152)”
From Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017) · cites this paper as [152]
SIGLEC1/CD169 is not expressed in microglia in health or disease and has been proposed as a marker for invading monocyte-derived macrophages in the CNS.
“sialoadhesin (SIGLEC1; also known as CD169) is a marker for mature dendritic cells and macrophages in both mice and humans48 and has been proposed as a marker for invading monocyte-derived macrophages in the CNS as it is not expressed in microglia in health or disease49–52.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · see citing works
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257 · see citing works
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605 · see citing works
Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,478 · see citing works
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature · doi:10.1038/nature07511 · Cited by 2,349 · see citing works
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works
Direct multiplexed measurement of gene expression with color-coded probe pairs
Geiss, G. K., Bumgarner, R. E., Birditt, B., Dahl, T., Dowidar, N., Dunaway, D. L., Fell, H. P., Ferree, S., George, R. D., Grogan, T., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1385 · Cited by 2,066 · see citing works
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866 · see citing works
lincRNAs act in the circuitry controlling pluripotency and differentiation
Guttman, M., Donaghey, J., Carey, B. W., Garber, M. G., Grenier, J. K., Munson, G., Young, G., Lucas, A. B., Ach, R. A., Bruhn, L., et al. (2011) · Nature · doi:10.1038/nature10398 · Cited by 1,845 · see citing works
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623 · see citing works
Physiological and pathological roles for microRNAs in the immune system
O’Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature reviews. Immunology · doi:10.1038/nri2708 · Cited by 1,546 · see citing works
Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1
Bruijn, L. I., Houseweart, M. K., Kato, S., Anderson, K. L., Anderson, S., Ohama, E., Reaume, A. G., Scott, R. W., & Cleveland, D. W. (1998) · Science · doi:10.1126/science.281.5384.1851 · Cited by 1,231 · see citing works
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183 · see citing works
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107 · see citing works
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089 · see citing works
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061 · see citing works
Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
Lu, L., Boldin, M., Chaudhry, A., Lin, L.-L., Taganov, K. D., Hanada, T., Yoshimura, A., Baltimore, D., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.08.012 · Cited by 1,003 · see citing works
MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development
O'Connell, R. M., Kahn, D., Gibson, W. S. J., Round, J. L., Scholz, R. L., Chaudhuri, A. A., Kahn, M. E., Rao, D. S., & Baltimore, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.009 · Cited by 889 · see citing works
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Gabriely, G., Wurdinger, T., Kesari, S., Esau, C. C., Burchard, J., Linsley, P. S., & Krichevsky, A. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00479-08 · Cited by 888 · cited 1× · see citing works
“ed using the ΔCt method as described elsewhere (81) and normalized to”
Self-citationThe myeloid cells of the central nervous system parenchyma
Ransohoff, R. M., & Cardona, A. E. (2010) · Nature · doi:10.1038/nature09615 · Cited by 804 · see citing works
Lu, L., Thai, T., Calado, D. P., Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G. B., Lee, H., Yoshimura, A., Rajewsky, K., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.010 · Cited by 784 · see citing works
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G. D., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3113 · Cited by 780 · see citing works
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
Ischiropoulos, H., & Beckman, J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317638 · Cited by 748 · see citing works
Beers, D. R., Henkel, J. S., Xiao, Q., Zhao, W., Wang, J., Yen, A. A., Siklos, L., McKercher, S. R., & Appel, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607423103 · Cited by 733 · see citing works
Ceppi, M., Pereira, P. M., Dunand-Sauthier, I., Barras, E., Reith, W., Santos, M. A. S., & Pierre, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811073106 · Cited by 718 · see citing works
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649 · see citing works
Björkqvist, M., Wild, E. J., Thiele, J., Silvestroni, A., André, R., Lahiri, N., Raibon, E., Lee, R. V., Benn, C., Soulet, D., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080178 · Cited by 646 · see citing works
Saederup, N., Cardona, A. E., Croft, K., Mizutani, M., Cotleur, A. C., Tsou, C.-L., Ransohoff, R. M., & Charo, I. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013693 · Cited by 599 · see citing works
Junker, A., Krumbholz, M., Eisele, S., Mohan, H., Augstein, F., Bittner, R., Lassmann, H., Wekerle, H., Hohlfeld, R., & Meinl, E. (2009) · Brain · doi:10.1093/brain/awp300 · Cited by 595 · see citing works
Henkel-Tigges, J., Engelhardt, J., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R., & Appel, S. H. (2003) · Annals of Neurology · doi:10.1002/ana.10805 · Cited by 554 · see citing works
Inflammatory processes in amyotrophic lateral sclerosis
McGeer, P. L., & McGeer, E. G. (2002) · Muscle & Nerve · doi:10.1002/mus.10191 · Cited by 470 · see citing works
Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., & Appel, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807419105 · Cited by 468 · see citing works
Asano, K., Nabeyama, A., Miyake, Y., Qiu, C., Kurita, A., Tomura, M., Kanagawa, O., Fujii, S., & Tanaka, M. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.011 · Cited by 454 · see citing works
Mildner, A., Mack, M., Schmidt, H., Brück, W., Djukic, M., Zabel, M. D., Hille, A., Priller, J., & Prinz, M. (2009) · Brain · doi:10.1093/brain/awp144 · Cited by 445 · see citing works
King, I. L., Dickendesher, T. L., & Segal, B. M. (2009) · Blood · doi:10.1182/blood-2008-07-168575 · Cited by 444 · see citing works
Urushitani, M., Sik, A., Sakurai, T., Nukina, N., Takahashi, R., & Julien, J.-P. (2006) · Nature Neuroscience · doi:10.1038/nn1603 · Cited by 419 · see citing works
Offner, H., Subramanian, S., Parker, S. M., Wang, C., Afentoulis, M. E., Lewis, A. D., Vandenbark, A. A., & Hurn, P. D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6523 · Cited by 412 · see citing works
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
Chiu, I., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S., Vartanian, T., Brown, R. H., & Carroll, M. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0804610105 · Cited by 374 · see citing works
Absence of the Chemokine Receptor CCR2 Protects Against Cerebral Ischemia/Reperfusion Injury in Mice
Dimitrijevic, O. B., Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2007) · Stroke · doi:10.1161/01.str.0000259709.16654.8f · Cited by 368 · see citing works
Bandrés, E., Bitarte, N., Arias, F., Agorreta, J., Fortes, P., Agirre, X., Zárate, R., Díaz-González, J. A., Ramírez, N., Sola, J. J., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1818 · Cited by 346 · see citing works
Li, T., Morgan, M. J., Choksi, S., Zhang, Y., Kim, Y., & Liu, Z.-G. (2010) · Nature Immunology · doi:10.1038/ni.1918 · Cited by 339 · see citing works
Swarup, V., Phaneuf, D., Dupré, N., Petri, S., Strong, M. J., Križ, J., & Julien, J. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20111313 · Cited by 338 · see citing works
Park, J. M., Greten, F. R., Wong, A. W., Westrick, R. J., Arthur, J. S. C., Otsu, K., Hoffmann, A., Montminy, M., & Karin, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.08.010 · Cited by 320 · see citing works
Digital Multiplexed Gene Expression Analysis Using the NanoString nCounter System
Kulkarni, M. M. (2011) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb25b10s94 · Cited by 309 · see citing works
Trial of celecoxib in amyotrophic lateral sclerosis
Cudkowicz, M., Shefner, J. M., Schoenfeld, D., Zhang, H., Andreasson, K. I., Rothstein, J. D., & Drachman, D. B. (2006) · Annals of Neurology · doi:10.1002/ana.20903 · Cited by 302 · see citing works
Self-citationSilencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis
Murugaiyan, G., Beynon, V., Mittal, A., Joller, N., & Weiner, H. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003952 · Cited by 289 · see citing works
Self-citationKim, D. W., Gazourian, L., Quadri, S. A., Raphaëlle, Sherr, D. H., & Sonenshein, G. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203945 · Cited by 280 · see citing works
The spleen contributes to stroke‐induced neurodegeneration
Ajmo, C. T., Vernon, D. O. L., Collier, L. A., Hall, A. A., Garbuzova-Davis, S. N., Willing, A. E., & Pennypacker, K. R. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21661 · Cited by 272 · see citing works
Proinflammatory Role for let-7 MicroRNAS in Experimental Asthma
Polikepahad, S., Knight, J. M., Naghavi, A. O., Oplt, T., Creighton, C. J., Shaw, C. A., Benham, A. L., Kim, J. K., Soibam, B., Harris, R. A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145698 · Cited by 242 · see citing works
Kim, Y., Kamada, N., Shaw, M. H., Warner, N. E., Chen, G., Franchi, L., & Núñez, G. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.013 · Cited by 242 · see citing works
Zhou, R., Hu, G.-K., Liu, J., Gong, A., Drescher, K., & Chen, X.-M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000681 · Cited by 209 · see citing works
Targeting of SMAD5 links microRNA-155 to the TGF-β pathway and lymphomagenesis
Rai, D., Kim, S., McKeller, M. R., Dahia, P. L. M., & Aguiar, R. C. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910667107 · Cited by 204 · see citing works
MicroRNA-155 Targets SMAD2 and Modulates the Response of Macrophages to Transforming Growth Factor-β
Louafi, F., Martínez-Nuñez, R. T., & Sánchez-Elsner, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146852 · Cited by 201 · see citing works
Hsieh, T., Tsai, C., Hsu, C., Kuo, P., Lee, J., Chai, C., Wang, S., & Tsai, E. (2011) · The FASEB Journal · doi:10.1096/fj.11-191742 · Cited by 199 · see citing works
Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
Banerjee, R., Mosley, R. L., Reynolds, A. D., Dhar, A., Jackson-Lewis, V. R., Gordon, P. H., Przedborski, S., & Gendelman, H. E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002740 · Cited by 198 · see citing works
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
Chiu, I. M., Phatnani, H. P., Kuligowski, M., Tapia, J. C., Carrasco, M. A., Zhang, M., Maniatis, T., & Carroll, M. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911405106 · Cited by 194 · see citing works
Mantovani, S., Garbelli, S., Pasini, A., Alimonti, D., Perotti, C. G., Melazzini, M. G., Bendotti, C., & Mora, G. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.012 · Cited by 190 · see citing works
Wu, D., Nishimura, N., Kuo, V., Fiehn, O., Shahbaz, S., Winkle, L. S. V., Matsumura, F., & Vogel, C. F. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220202 · Cited by 186 · see citing works
Jennewein, C., von Knethen, A., Schmid, T., & Brüne, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.066399 · Cited by 183 · see citing works
Braun, N., Sévigny, J., Robson, S. C., Enjyoji, K., Guckelberger, O., Hammer, K., Virgilio, F. D., & Zimmermann, H. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01342.x · Cited by 169 · see citing works
Malkov, V. A., Serikawa, K. A., BALANTAC, N., Watters, J., Geiss, G. K., Mashadi-Hossein, A., & Fare, T. L. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-80 · Cited by 161 · see citing works
Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Etzrodt, M., Cortez‐Retamozo, V., Newton, A., Zhao, J. L., Ng, A., Wildgruber, M., Romero, P. J., Wurdinger, T. D., Xavier, R. J., Geissmann, F., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.009 · Cited by 117 · see citing works
Lincecum, J. M., Vieira, F. G., Wang, M. Z., Thompson, K., Zutter, G. S. D., Kidd, J. D., Moreno, A., Sànchez, R., Carrion, I. J., Levine, B. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.557 · Cited by 114 · see citing works
Schaefer, J. S., Montufar‐Solis, D., Vigneswaran, N., & Klein, J. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100922 · Cited by 109 · see citing works
Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation
Drachman, D. B., Chaudhry, V., Cornblath, D. R., Kuncl, R. W., Pestronk, A., Clawson, L., Mellits, E. D., Quaskey, S. A., Quinn, T. C., Calkins, A., et al. (1994) · Annals of Neurology · doi:10.1002/ana.410350205 · Cited by 97 · see citing works
Stommel, E. W., Cohen, J. A., Fadul, C. E., Cogbill, C. H., Graber, D. J., Kingman, L. S., MacKenzie, T. A., Smith, J. Y. C., & Harris, B. T. (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802709416 · Cited by 88 · see citing works
Fendrick, S. E., Xue, Q., & Streit, W. J. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-9 · Cited by 88 · see citing works
Expression of Ah receptor (TCDD receptor) during human monocytic differentiation
Hayashio, S.-I., Okabe‐Kado, J., Honma, Y., & Kawajiri, K. (1995) · Carcinogenesis · doi:10.1093/carcin/16.6.1403 · Cited by 72 · see citing works
Nagata, T., Nagano, I., Shiote, M., Narai, H., Murakami, T., Hayashi, T., Shoji, M., & Abe, K. (2007) · Neurological Research · doi:10.1179/016164107x229795 · Cited by 64 · see citing works
Brown, R. H., Hauser, S. L., Harrington, H., & Weiner, H. L. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520040063021 · Cited by 51 · see citing works
Self-citationRoubelakis, M. G., Zotos, P., Papachristoudis, G., Michalopoulos, I., Pappa, K. I., Anagnou, N. P., & Κοσσίδα, Σ. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-s6-s20 · Cited by 44 · see citing works
Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1
Sargsyan, S. A., Blackburn, D. J., Barber, S. C., Monk, P. N., & Shaw, P. J. (2009) · Neuroreport · doi:10.1097/wnr.0b013e328331e8fa · Cited by 39 · see citing works
Hirata, Y., Masuda, Y., Kakutani, H., Higuchi, T., Takada, K., Itô, A., Nakagawa, Y., & Ishii, H. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.12.019 · Cited by 37 · see citing works
Treatment of ALS with high dose pulse cyclophosphamide
Smith, S. A., Miller, R. G., Murphy, J. R., & Ringel, S. P. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90188-0 · Cited by 37 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works
Self-citationMicroglia Function in the Central Nervous System During Health and Neurodegeneration
Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894 · see citing works
Self-citationIdentification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,579 · see citing works
Self-citationMicroglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works
Microglial signatures and their role in health and disease
Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046 · see citing works
Self-citationNovel Markers to Delineate Murine M1 and M2 Macrophages
Jablonski, K., Amici, S. A., Webb, L., Ruiz‐Rosado, J. D. D., Popovich, P. G., Partida‐Sánchez, S., & Guerau‐de‐Arellano, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145342 · Cited by 1,003 · see citing works
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works
The changing scene of amyotrophic lateral sclerosis
Robberecht, W., & Philips, T. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3430 · Cited by 957 · see citing works
New insights into the multidimensional concept of macrophage ontogeny, activation and function
Ginhoux, F., Schultze, J. L., Murray, P. J., Ochando, J., & Biswas, S. K. (2015) · Nature Immunology · doi:10.1038/ni.3324 · Cited by 832 · see citing works
Minocycline selectively inhibits M1 polarization of microglia
Kobayashi, K., Imagama, S., Ohgomori, T., Hirano, K., Uchimura, K., Sakamoto, K., Hirakawa, A., Takeuchi, H., Suzumura, A., Ishiguro, N., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.54 · Cited by 742 · see citing works
The biphasic function of microglia in ischemic stroke
Ma, Y., Wang, J., Wang, Y., & Yang, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 724 · see citing works
Chiu, I. M., Morimoto, E. T. A., Goodarzi, H., Liao, J. T., O’Keeffe, S., Phatnani, H. P., Muratet, M., Carroll, M. C., Levy, S., Tavazoie, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.018 · Cited by 651 · see citing works
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638 · see citing works
Tay, T. L., Savage, J. C., Hui, C. W., Bisht, K., & Tremblay, M. (2017) · The Journal of Physiology · doi:10.1113/jp272134 · Cited by 562 · see citing works
Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., Gerritse, I., Fasnacht, R., Barres, B. A., Thaler, J. P., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.015 · Cited by 477 · see citing works
Origin of microglia: current concepts and past controversies
Ginhoux, F., & Prinz, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020537 · Cited by 446 · see citing works
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Müller‐Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4944 · Cited by 430 · see citing works
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works
Dark microglia: A new phenotype predominantly associated with pathological states
Bisht, K., Sharma, K. P., Lecours, C., Gabriela Sánchez, M., El Hajj, H., Milior, G., Olmos‐Alonso, A., Gómez‐Nicola, D., Luheshi, G., Vallières, L., et al. (2016) · Glia · doi:10.1002/glia.22966 · Cited by 421 · see citing works
Self-citationMacrophages at CNS interfaces: Ontogeny and function in health and disease
Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0201-x · Cited by 416 · see citing works
Cronk, J. C., Filiano, A. J., Louveau, A., Marin, I., Marsh, R., Ji, E., Goldman, D. H., Smirnov, I., Geraci, N., Acton, S., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180247 · Cited by 412 · see citing works
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
Pandya, H., Shen, M. J., Ichikawa, D. M., Sedlock, A. B., Choi, Y., Johnson, K. R., Kim, G., Brown, M. A., Elkahloun, A. G., Maric, D., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4534 · Cited by 405 · see citing works
Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles
Getts, D. R., Terry, R. L., Getts, M. T., Deffrasnes, C., Müller, M., van Vreden, C., Ashhurst, T. M., Chami, B., McCarthy, D., Wu, H., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007563 · Cited by 378 · see citing works
Liu, J., & Wang, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01005 · Cited by 376 · see citing works
Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24304 · Cited by 358 · see citing works
Self-citationVarvel, N. H., Neher, J. J., Bosch, A., Wang, W., Ransohoff, R. M., Miller, R. J., & Dingledine, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604263113 · Cited by 357 · see citing works
Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling
Crotti, A., & Ransohoff, R. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.013 · Cited by 323 · see citing works
Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome
Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal · doi:10.15252/embj.2018101064 · Cited by 351 · see citing works
Myeloid Cells in the Central Nervous System
Herz, J., Filiano, A. J., Wiltbank, A. T., Yogev, N., & Kipnis, J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.007 · Cited by 332 · see citing works
Microglia, Lifestyle Stress, and Neurodegeneration
Madore, C., Yin, Z., Leibowitz, J. A., & Butovsky, O. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.003 · Cited by 310 · see citing works
Self-citationLy6 family proteins in neutrophil biology
Lee, P. Y., Wang, J., Parisini, E., Dascher, C. C., & Nigrovic, P. A. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0113014 · Cited by 304 · see citing works
Rice, R. A., Spangenberg, E. E., Yamate-Morgan, H., Lee, R. J., Arora, R. P. S., Hernandez, M. X., Tenner, A. J., West, B. L., & Green, K. N. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0336-15.2015 · Cited by 270 · see citing works
Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
Zhao, W., Beers, D. R., & Appel, S. H. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9489-x · Cited by 298 · see citing works
Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
Grozdanov, V., Bliederhaeuser, C., Ruf, W. P., Roth, V., Fundel-Clemens, K., Zondler, L., Brenner, D., Martin-Villalba, A., Hengerer, B., Kassubek, J., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1345-4 · Cited by 295 · see citing works
Functional differences between microglia and monocytes after ischemic stroke
Ritzel, R. M., Patel, A. R., Grenier, J. M., Crapser, J., Verma, R., Jellison, E. R., & McCullough, L. D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0329-1 · Cited by 295 · see citing works
London, A., Cohen, M., & Schwartz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00034 · Cited by 282 · see citing works
Macrophage subsets and microglia in multiple sclerosis
Bogie, J. F. J., Stinissen, P., & Hendriks, J. J. A. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1310-2 · Cited by 279 · see citing works
Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
Hooten, K. G., Beers, D. R., Zhao, W., & Appel, S. H. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0329-3 · Cited by 287 · see citing works
Inflammatory Disequilibrium in Stroke
Petrovic‐Djergovic, D., Goonewardena, S. N., & Pinsky, D. J. (2016) · Circulation Research · doi:10.1161/circresaha.116.308022 · Cited by 265 · see citing works
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 266 · see citing works
Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis
Gandhi, R., Healy, B. C., Gholipour, T., Egorova, S., Musallam, A., Hussain, M. S., Nejad, P., Patel, B., Hei, H., Khoury, S. J., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23880 · Cited by 258 · see citing works
Self-citationRaman, R., Allen, S. P., Goodall, G., Kramer, S., Ponger, L., Heath, P. R., Milo, M., Hollinger, H. C., Walsh, T., Highley, J. R., et al. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12147 · Cited by 254 · see citing works
Glial cells in amyotrophic lateral sclerosis
Philips, T., & Rothstein, J. D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.015 · Cited by 255 · see citing works
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease
Thome, A. D., Harms, A. S., Volpicelli‐Daley, L. A., & Standaert, D. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3900-15.2016 · Cited by 249 · see citing works
Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease
Allen Reish, H. E., & Standaert, D. G. (2015) · Journal of Parkinson’s Disease · doi:10.3233/jpd-140491 · Cited by 244 · see citing works
The involvement of microRNAs in neurodegenerative diseases
Maciotta, S., Meregalli, M., & Torrente, Y. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00265 · Cited by 247 · see citing works
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Koval, E. D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., Chau, B. N., Wu, G. F., & Miller, T. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt261 · Cited by 236 · see citing works
Harms, A. S., Thome, A. D., Yan, Z., Schonhoff, A. M., Williams, G. P., Li, X., Liu, Y., Qin, H., Benveniste, E. N., & Standaert, D. G. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2017.11.010 · Cited by 236 · see citing works
Morphology of Microglia Across Contexts of Health and Disease
Savage, J. C., Carrier, M., & Tremblay, M.-È. (2019) · Methods in Molecular Biology · doi:10.1007/978-1-4939-9658-2_2 · Cited by 232 · see citing works
Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era
Paez-Colasante, X., Figueroa‐Romero, C., Sakowski, S. A., Goutman, S. A., & Feldman, E. L. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.57 · Cited by 224 · see citing works
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216 · see citing works
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 211 · see citing works
P2Y12 expression and function in alternatively activated human microglia
Moore, C. S., Ase, A. R., Kinsara, A., Rao, V. T. S., Michell-Robinson, M., Leong, S. Y., Butovsky, O., Ludwin, S. K., Séguéla, P., Bar-Or, A., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000080 · Cited by 212 · see citing works
Self-citationCirculating miRNAs as Biomarkers for Neurodegenerative Disorders
Grasso, M., Piscopo, P., Confaloni, A., & Denti, M. A. (2014) · Molecules · doi:10.3390/molecules19056891 · Cited by 206 · see citing works
Microglia centered pathogenesis in ALS: insights in cell interconnectivity
Brites, D. M. T. O., & Vaz, A. R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00117 · Cited by 201 · see citing works
Functional diversity of microglia – how heterogeneous are they to begin with?
Hanisch, U.-K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00065 · Cited by 195 · see citing works
Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression
Murdock, B. J., Zhou, T., Kashlan, S. R., Little, R. J. A., Goutman, S. A., & Feldman, E. L. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.2255 · Cited by 202 · see citing works
M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?
Moehle, M. S., & West, A. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.018 · Cited by 198 · see citing works
Microglial Phenotype and Adaptation
Eggen, B. J. L., Raj, D. D. A., Hanisch, U., & Boddeke, H. W. G. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9490-4 · Cited by 176 · see citing works
Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Zhao, W., Beers, D. R., Hooten, K. G., Sieglaff, D. H., Zhang, A., Sundaram, S. K., Traini, C., Halsey, W. S., Hughes, A. M., Sathe, G. M., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0357 · Cited by 176 · see citing works
Rui, W., Li, S., Xiao, H., Xiao, M., & Shi, J. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa060 · Cited by 175 · see citing works
Martínez‐Muriana, A., Mancuso, R., Francos-Quijorna, I., Olmos‐Alonso, A., Osta, R., Perry, V. H., Navarro, X., Gómez‐Nicola, D., & López‐Vales, R. (2016) · Scientific Reports · doi:10.1038/srep25663 · Cited by 165 · see citing works
Mammana, S., Fagone, P., Cavalli, E., Basile, M. S., Petralia, M. C., Nicoletti, F., Bramanti, P., & Mazzon, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030831 · Cited by 166 · see citing works
Neuronal dark matter: the emerging role of microRNAs in neurodegeneration
Goodall, E. F., Heath, P. R., Bandmann, O., Kirby, J., & Shaw, P. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00178 · Cited by 187 · see citing works
Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis
Figueroa‐Romero, C., Hur, J., Bender, D. E., Delaney, C. E., Cataldo, M. D., Smith, A. L., Yung, R. L., Ruden, D. M., Callaghan, B. C., & Feldman, E. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052672 · Cited by 161 · see citing works
Peripheral monocytes are functionally altered and invade the CNS in ALS patients
Zondler, L., Müller, K., Khalaji, S., Bliederhäuser, C., Ruf, W. P., Grozdanov, V., Thiemann, M., Fundel-Clemes, K., Freischmidt, A., Holzmann, K., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1548-y · Cited by 154 · see citing works
Bosco, A., Romero, C. O., Breen, K., Chagovetz, A. A., Steele, M. R., Ambati, B. K., & Vetter, M. L. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.018788 · Cited by 158 · see citing works
Li, M., Li, Z., Ren, H., Jin, W., Wood, K., Liu, Q., Sheth, K. N., & Shi, F. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16666551 · Cited by 158 · see citing works
Rodent models of amyotrophic lateral sclerosis
McGoldrick, P., Joyce, P. I., Fisher, E., & Greensmith, L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.012 · Cited by 156 · see citing works
Trías, E., Ibarburu, S., Barreto‐Núñez, R., Babdor, J., Maciel, T. T., Guillo, M., Gros, L., Dubreuil, P. C., Díaz‐Amarilla, P., Cassina, P., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0620-9 · Cited by 155 · see citing works
Control of the Inflammatory Macrophage Transcriptional Signature by miR-155
Jablonski, K., Gaudet, A. D., Amici, S. A., Popovich, P. G., & Guerau‐de‐Arellano, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159724 · Cited by 152 · see citing works
Innate and adaptive immune responses in the CNS
Waisman, A., Liblau, R., & Becher, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00141-6 · Cited by 151 · see citing works
Parisi, C., Arisi, I., D’Ambrosi, N., Storti, A. E., Brandi, R., D’Onofrio, M., & Volonté, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.491 · Cited by 153 · see citing works
Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
Staff, N. P., Jones, D. T., & Singer, W. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.001 · Cited by 150 · see citing works
Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
Vahsen, B. F., Gray, E., Thompson, A. G., Ansorge, O., Anthony, D. C., Cowley, S. A., Talbot, K., & Turner, M. R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00487-8 · Cited by 147 · see citing works
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia
Kim, S. J., & Li, J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.238 · Cited by 146 · see citing works
Watson, C. N., Belli, A., & Pietro, V. D. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00364 · Cited by 146 · see citing works
Ontogeny and Functions of Central Nervous System Macrophages
Katsumoto, A., Lu, H., de Miranda, A. S., & Ransohoff, R. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400716 · Cited by 146 · see citing works
Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors
Anttila, J. E., Whitaker, K. W., Wires, E. S., Harvey, B. K., & Airavaara, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.003 · Cited by 144 · see citing works
Inflammatory monocytes and the pathogenesis of viral encephalitis
Terry, R. L., Getts, D. R., Deffrasnes, C., van Vreden, C., Campbell, I. L., & King, N. J. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-270 · Cited by 134 · see citing works
How to reprogram microglia toward beneficial functions
Fumagalli, M., Lombardi, M., Gressèns, P., & Verderio, C. (2018) · Glia · doi:10.1002/glia.23484 · Cited by 134 · see citing works
Gene therapy for neurodegenerative diseases
O’Connor, D. M., & Boulis, N. M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.06.001 · Cited by 129 · see citing works
Microglia: unique and common features with other tissue macrophages
Prinz, M., Tay, T. L., Wolf, Y., & Jung, S. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1267-1 · Cited by 126 · see citing works
Béland, L.-C., Markovinovic, A., Jakovac, H., De Marchi, F., Bilic, E., Mazzini, L., Kriz, J., & Munitic, I. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa124 · Cited by 125 · see citing works
Thinking laterally about neurodegenerative proteinopathies
Golde, T. E., Borchelt, D., Giasson, B. I., & Lewis, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66029 · Cited by 121 · see citing works
Differential contribution of microglia and monocytes in neurodegenerative diseases
Baufeld, C., O'Loughlin, E. K., Calcagno, N., Madore, C., & Butovsky, O. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1795-7 · Cited by 123 · see citing works
Self-citationThe human gut microbiota in people with amyotrophic lateral sclerosis
Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., et al. (2021) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1828475 · Cited by 123 · see citing works
Self-citationChiot, A., Zaïdi, S., Iltis, C., Ribon, M., Berriat, F., Schiaffino, L., Jolly, A., de la Grange, P., Mallat, M., Bohl, D., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00718-z · Cited by 122 · see citing works
Tönges, L., Günther, R., Suhr, M., Jansen, J., Balck, A., Saal, K., Barski, E., Nientied, T., Götz, A. A., Koch, J., et al. (2014) · Glia · doi:10.1002/glia.22601 · Cited by 121 · see citing works
Microglia in neurodegenerative diseases
Xu, Y., Jin, M.-Z., Yang, Z., & Jin, M.-Z. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290881 · Cited by 118 · see citing works
microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases
Basak, I., Patil, K. S., Alves, G. W., Larsen, J. P., & Møller, S. G. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2093-x · Cited by 120 · see citing works
Apolloni, S., Amadio, S., Parisi, C., Matteucci, A., Potenza, R. L., Armida, M., Popoli, P., D’Ambrosi, N., & Volonté, C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.017038 · Cited by 118 · see citing works
Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk
Passaro, A. P., Lebos, A. L., Yao, Y., & Stice, S. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676621 · Cited by 118 · see citing works
Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic
Mancuso, R., & Navarro, X. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.004 · Cited by 114 · see citing works
The therapeutics of Alzheimer's disease: Where we stand and where we are heading
Selkoe, D. J. (2013) · Annals of Neurology · doi:10.1002/ana.24001 · Cited by 112 · see citing works
Central nervous system myeloid cells as drug targets: current status and translational challenges
Biber, K. P. H., Möller, T., Boddeke, E., & Prinz, M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.14 · Cited by 111 · see citing works
Martin, E., Behi, M. E., Fontaine, B., & Delarasse, C. (2017) · Journal of Visualized Experiments · doi:10.3791/55781 · Cited by 111 · see citing works
Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis
Vu, L. T., & Bowser, R. P. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0503-x · Cited by 108 · see citing works
Lewis, N. D., Hill, J. D., Juchem, K. W., Stefanopoulos, D. E., & Modis, L. K. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.014 · Cited by 106 · see citing works
MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis
Ricci, C., Marzocchi, C., & Battistini, S. (2018) · Cells · doi:10.3390/cells7110219 · Cited by 106 · see citing works
- Authors
- Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., Doykan, C. E., Wu, P. M., Gali, R. R., Iyer, L. K., Lawson, R., Berry, J., Krichevsky, A. M., Cudkowicz, M. E., & Weiner, H. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Tufts University (US)
- Corresponding author
- Weiner, Howard L.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2012-09-04
- Volume
- 122
- Issue
- 9
- Pages
- 3063-3087
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3428086
- OpenAlex
- W2119656827
- Cited by
- 481
- References
- 81
- Citations by year
- 2026: 6 · 2025: 18 · 2024: 23 · 2023: 32 · 2022: 41 · 2021: 35 · 2020: 46 · 2019: 23 · 2018: 35 · 2017: 47 · 2016: 50 · 2015: 46 · 2014: 42 · 2013: 28 · 2012: 7
- FWCI
- 25.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- ALS Association
- Harvard NeuroDiscovery Center
- Brigham and Women's Hospital
- National Institutes of Health
- Center for Neuroscience Research (P30 NS047243)
- National Institute on Aging (AG027437, R01AG027437)
- National Institute of Neurological Disorders and Stroke (P30NS047243, R01NS088137)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- amyotrophic lateral sclerosis, inflammatory monocytes, microRNA signature, innate immunity, microglia, monocyte recruitment, spinal cord, CCR2, MCP-1, Ly6C, macrophage polarization, neuronal loss, disease biomarkers, therapeutic target
- MeSH terms
- Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Antibodies, Monoclonal, Antigens, Ly, Apyrase, Chemotaxis, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Rats, Inbred Lew, Spinal Cord, Spleen, Superoxide Dismutase, Transcription Factors, Antigens, CD, Macrophages, Alveolar, Apoptosis, Microglia, Inflammation Mediators, Oligonucleotide Array Sequence Analysis, RNA Interference, MicroRNAs, Cell Proliferation, Mice, Rats, Gene Regulatory Networks, Metabolic Networks and Pathways, Immunomodulation, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
