The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells
Open accessAbstract
The innate immune system is equipped with many molecular sensors for microbial DNA/RNA to quickly mount antimicrobial host immune responses. In this paper, we identified DHX9, a DExDc helicase family member, as an important viral dsRNA sensor in myeloid dendritic cells (mDCs). Knockdown of DHX9 expression by small heteroduplex RNA dramatically blocked the ability of mDCs to produce IFN-α/β and proinflammatory cytokines in response to polyinosine-polycytidylic acid, influenza A, and reovirus. DHX9 could specifically bind polyinosine-polycytidylic acid via its double-strand RNA binding motifs. DHX9 interacted with IPS-1 via the HelicC-HA2-DUF and CARD domains of DHX9 and IPS-1, respectively. Knockdown of DHX9 expression in mDCs blocked the activation of NF-κB and IFN regulatory factor 3 by dsRNA. Collectively, these results suggest that DHX9 is an important RNA sensor that is dependent on IPS-1 to sense pathogenic RNA.
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Cites
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
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Cited by
Paludan, S. R., & Bowie, A. G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.004 · Cited by 759
STING and the innate immune response to nucleic acids in the cytosol
Burdette, D. L., & Vance, R. E. (2013) · Nature Immunology · doi:10.1038/ni.2491 · Cited by 501
Double-Stranded RNA Sensors and Modulators in Innate Immunity
Hur, S. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041356 · Cited by 420
Zheng, Q., Hou, J., Zhou, Y., Li, Z., & Cao, X. (2017) · Nature Immunology · doi:10.1038/ni.3830 · Cited by 367
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Brisse, M., & Ly, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01586 · Cited by 365
Metadata
- Authors
- Zhang, Z., Yuan, B., Lu, N., Facchinetti, V., & Liu, Y.-J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-01
- Volume
- 187
- Issue
- 9
- Pages
- 4501-4508
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2109696635
- Cited by
- 185
- References
- 8
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, Z., Yuan, B., Lu, N., Facchinetti, V., & Liu, Y.-J. (2011). DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1101307
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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