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Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans
Abstract
Phytohemagglutinin responsiveness of peripheral blood lymphocytes declines in aged humans. Older humans exhibit a rise in the incidence of autoantibodies. The incidence of autoantibodies becomes significantly greater among older subjects over 80 years of age and is most significant in humans with low lymphocyte phytohemagglutinin responses. Serum levels of IgG and IgA were increased in subjects surviving beyond the 7th decade. Correlations could not be detected between serum immunoglobulin levels, titers of individual autoantibodies and the lymphocyte response to phytohemagglutinin. These observations suggest that hyperglobulinemia, impaired lymphocyte phytohemagglutinin responsiveness, and increased frequency of autoantibodies are characteristic of surviving older humans and represent associated events in the natural history of human life.
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Citations
Cited by
Regulation of the immune response by prostaglandins
Goodwin, J. S., & Webb, D. R. (1980) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(80)90024-0 · Cited by 768
Age Influence on the Immune System
Makinodan, T., & Kay, M. M. B. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60047-4 · Cited by 699
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
Meydani, S., Barklund, M., Liu, S., Meydani, M., Miller, R., Cannon, J., Morrow, F., Rocklin, R., & Blumberg, J. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.3.557 · Cited by 585
Metadata
- Authors
- Hallgren, H. M., Buckley, C. E., Gilbertsen, V. A., & Yunis, E. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-10-01
- Volume
- 111
- Issue
- 4
- Pages
- 1101-1107
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1537863230
- Cited by
- 282
- References
- 0
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans. https://app.cochat.ai/papers/10.4049/jimmunol.111.4.1101
- The paper
- Hallgren, H. M., Buckley, C. E., Gilbertsen, V. A., & Yunis, E. J. (1973). Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans. The Journal of Immunology. https://doi.org/10.4049/jimmunol.111.4.1101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
