IL-17 and TNF-α Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

Griffin, Gabriel K; Newton, Gail; Tarrio, Margarite L; Bu, De-xiu; Maganto-Garcia, Elena; Azcutia, Veronica; Alcaide, Pilar; Grabie, Nir; Luscinskas, Francis W; Croce, Kevin J; Lichtman, Andrew H

doi:10.4049/jimmunol.1200385

IL-17 and TNF-α Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

IL-17A (IL-17) is the signature cytokine produced by Th17 cells and has been implicated in host defense against infection and the pathophysiology of autoimmunity and cardiovascular disease. Little is known, however, about the influence of IL-17 on endothelial activation and leukocyte influx to si…