Purinergic regulation of the immune system
Abstract
Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling molecules by activating cell-surface P2 purinergic receptors that elicit pro-inflammatory immune responses. Over time, extracellular nucleotides are metabolized to adenosine, leading to reduced P2 signalling and increased signalling through anti-inflammatory adenosine (P1 purinergic) receptors. Here, we review how local purinergic signalling changes over time during tissue responses to injury or disease, and we discuss the potential of targeting purinergic signalling pathways for the immunotherapeutic treatment of ischaemia, organ transplantation, autoimmunity or cancer.
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Extracellular ATP induces epithelial and mast cell IL-33 production.
“extracellular ATP, which induces epithelial and mast cell IL-33 production”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Cekic and Linden, 2016
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- Authors
- Cekic, C., & Linden, J.
- Affiliations
- Bilkent University (TR)
- La Jolla Institute for Immunology (US)
- Corresponding author
- Linden, Joel
- Venue
- Nature Reviews Immunology
- Published
- 2016-02-29
- Volume
- 16
- Issue
- 3
- Pages
- 177-192
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2292051166
- Cited by
- 787
- References
- 2
- Citations by year
- 2026: 54 · 2025: 57 · 2024: 61 · 2023: 79 · 2022: 105 · 2021: 78 · 2020: 83 · 2019: 95 · 2018: 82 · 2017: 71 · 2016: 22
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Bilkent University Institutional Repository (Bilkent University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Keywords
- purinergic signaling, extracellular nucleotides, ATP, ADP, adenosine, P2X receptors, adenosine receptors, innate immunity, adaptive immunity, inflammation, apoptosis, ischemia, organ transplantation, autoimmunity, cancer immunotherapy, immunotherapy
- MeSH terms
- Animals, Humans, Immunity, Innate, Purines, Signal Transduction, Adaptive Immunity
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