CoChat
Sign Up
Cited by 39

The DOI matches its Crossref record.

Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL‐4 and IL‐6

Liu, Anne Y, Dwyer, Dan F, Jones, Tatiana G, Bankova, Lora G, Shen, Shiliang, Katz, Howard R, Austen, K Frank, Gurish, Michael F·2013·The Journal of Immunology
DOI 10.4049/jimmunol.1202567PMC PMC3563837
Open this paper in CoChat — free account

Abstract

Mast cells (MC) and basophils share expression of the high-affinity receptor for IgE (FcεRI) but can be distinguished by their divergent expression of KIT and CD49b. In BALB/c mice, MC lineage cells expressing high levels of FcεRI by flow cytometry were seen only in bone marrow whereas those expressing intermediate levels of FcεRI were present in bone marrow and spleen of naive mice and in mesenteric lymph nodes (mLN) of Trichinella spiralis–infected mice. These FcεRI+KIT+CD49b− cells had a membrane phenotype similar to i.p. connective tissue-type MC, but were smaller and hypogranular by flow cytometry forward and side scatter profiles, respectively. Consistent with this, they lacked the prominent secretory granules identified by histochemistry and immunodetection for the MC-specific granule proteases that are readily seen in mature jejunal mucosal MC that also are induced by the infection and present at the same time. The concentration of these MC lineage cells in mLN determined by flow cytometry was comparable to that of MC progenitors (MCp) measured by limiting dilution and clonal expansion with maturation. We observed upregulation of IL-4 transcription by MCp in mLN and spleens of helminth-infected 4get mice, and we demonstrated by intracellular cytokine staining production of IL-4 and IL-6 by the mLN MCp in helminth-infected mice. Furthermore, treatment of helminth-infected mice with anti-FcεRI mAb, a protocol known to deplete basophils, also depleted mLN MCp. Thus, this study identifies a hypogranular subset of MCp recruited to mLN by helminth infection that may be an important unrecognized source of cytokines.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4049/jimmunol.1202567

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 40

  1. Kamiya, 1985, Prolonged expulsion of adult Trichinella spiralis and eosinophil infiltration in mast cell-deficient W/Wv mice, J. Helminthol., 59, 233, 10.1017/S0022149X00008002 · DOI
  2. Voehringer, 2006, Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system, J. Exp. Med., 203, 1435, 10.1084/jem.20052448 · DOI
  3. Sokol, 2008, A mechanism for the initiation of allergen-induced T helper type 2 responses, Nat. Immunol., 9, 310, 10.1038/ni1558 · DOI
  4. Yoshimoto, 2009, Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells, Nat. Immunol., 10, 706, 10.1038/ni.1737 · DOI
  5. Fukuzumi, 1990, Differences in irradiation susceptibility and turnover between mucosal and connective tissue-type mast cells of mice, Exp. Hematol., 18, 843
  6. Friend, 1996, Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype, J. Cell Biol., 135, 279, 10.1083/jcb.135.1.279 · DOI
  7. Friend, 1998, Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis, J. Immunol., 160, 5537, 10.4049/jimmunol.160.11.5537 · DOI
  8. Sonoda, 1983, Mast-cell precursors in various haematopoietic colonies of mice produced in vivo and in vitro, Br. J. Haematol., 53, 611, 10.1111/j.1365-2141.1983.tb07312.x · DOI
  9. Crapper, 1983, Frequency of mast cell precursors in normal tissues determined by an in vitro assay: antigen induces parallel increases in the frequency of P cell precursors and mast cells, J. Immunol., 131, 923, 10.4049/jimmunol.131.2.923 · DOI
  10. Guy-Grand, 1984, Gut mucosal mast cells: origin, traffic, and differentiation, J. Exp. Med., 160, 12, 10.1084/jem.160.1.12 · DOI
  11. Gurish, 2001, Intestinal mast cell progenitors require CD49dβ7 (α4β7 integrin) for tissue-specific homing, J. Exp. Med., 194, 1243, 10.1084/jem.194.9.1243 · DOI · Paper page
  12. Dillon, 1986, Limit dilution analysis of mast cell precursor frequency in the gut epithelium of normal and Trichinella spiralis infected mice, Parasite Immunol., 8, 503, 10.1111/j.1365-3024.1986.tb00865.x · DOI
  13. Parmentier, 1987, Effect of a Trichinella spiralis infection on the distribution of mast cell precursors in tissues of thymus-bearing and non-thymus-bearing (nude) mice determined by an in vitro assay, Immunology, 60, 565
  14. Jarboe, 1989, The mast cell-committed progenitor. I. Description of a cell capable of IL-3-independent proliferation and differentiation without contact with fibroblasts, J. Immunol., 142, 2405, 10.4049/jimmunol.142.7.2405 · DOI
  15. Rennick, 1995, Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: comparative effects of interleukin-3 (IL-3), IL-4, IL-10, and fibroblasts, Blood, 85, 57, 10.1182/blood.V85.1.57.bloodjournal85157 · DOI
  16. Ginsburg, 1967, The in vitro differentiation of mast cells: cultures of cells from immunized mouse lymph nodes and thoracic duct lymph on fibroblast monolayers, J. Cell Biol., 35, 685, 10.1083/jcb.35.3.685 · DOI
  17. Abonia, 2005, Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2, Blood, 105, 4308, 10.1182/blood-2004-09-3578 · DOI
  18. Artis, 2000, β7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection, Eur. J. Immunol., 30, 1656, 10.1002/1521-4141(200006)30:6<1656::AID-IMMU1656>3.0.CO;2-Z · DOI
  19. Abonia, 2006, Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung, Blood, 108, 1588, 10.1182/blood-2005-12-012781 · DOI
  20. Hallgren, 2007, Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors, Proc. Natl. Acad. Sci. USA, 104, 20478, 10.1073/pnas.0709651104 · DOI
  21. Xing, 2011, Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue, Proc. Natl. Acad. Sci. USA, 108, 14210, 10.1073/pnas.1111048108 · DOI
  22. Sawaguchi, 2012, Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness, J. Immunol., 188, 1809, 10.4049/jimmunol.1101746 · DOI
  23. Jones, 2009, Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells, J. Immunol., 183, 5251, 10.4049/jimmunol.0901471 · DOI
  24. McNeil, 1992, Translation and granule localization of mouse mast cell protease-5: immunodetection with specific antipeptide Ig, J. Immunol., 149, 2466, 10.4049/jimmunol.149.7.2466 · DOI
  25. Perrigoue, 2009, MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity, Nat. Immunol., 10, 697, 10.1038/ni.1740 · DOI
  26. Rottem, 1993, The effects of stem cell factor on the ultrastructure of FcεRI+ cells developing in IL-3-dependent murine bone marrow-derived cell cultures, J. Immunol., 151, 4950, 10.4049/jimmunol.151.9.4950 · DOI
  27. Yuan, 1998, Generation of a novel stem cell factor-dependent mast cell progenitor, J. Immunol., 161, 5143, 10.4049/jimmunol.161.10.5143 · DOI
  28. Jamur, 2005, Identification and characterization of undifferentiated mast cells in mouse bone marrow, Blood, 105, 4282, 10.1182/blood-2004-02-0756 · DOI · Paper page
  29. Arinobu, 2005, Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis, Proc. Natl. Acad. Sci. USA, 102, 18105, 10.1073/pnas.0509148102 · DOI · Paper page
  30. Voehringer, 2004, Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production, Immunity, 20, 267, 10.1016/S1074-7613(04)00026-3 · DOI
  31. Min, 2004, Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite, J. Exp. Med., 200, 507, 10.1084/jem.20040590 · DOI
  32. Mukai, 2005, Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells, Immunity, 23, 191, 10.1016/j.immuni.2005.06.011 · DOI
  33. Denzel, 2008, Basophils enhance immunological memory responses, Nat. Immunol., 9, 733, 10.1038/ni.1621 · DOI
  34. Saenz, 2010, IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses, Nature, 464, 1362, 10.1038/nature08901 · DOI
  35. Kim, 2010, Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3, J. Immunol., 184, 1143, 10.4049/jimmunol.0902447 · DOI
  36. Gessner, 2005, Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production, J. Immunol., 174, 1063, 10.4049/jimmunol.174.2.1063 · DOI
  37. Gurish, 2012, Developmental origin and functional specialization of mast cell subsets, Immunity, 37, 25, 10.1016/j.immuni.2012.07.003 · DOI
  38. Burd, 1989, Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines, J. Exp. Med., 170, 245, 10.1084/jem.170.1.245 · DOI
  39. Giacomin, 2012, Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection, J. Immunol., 189, 4371, 10.4049/jimmunol.1200691 · DOI
  40. Rodriguez Gomez, 2010, Basophils support the survival of plasma cells in mice, J. Immunol., 185, 7180, 10.4049/jimmunol.1002319 · DOI

Cited by

Sorted by citations

Metadata

Authors
Liu, A. Y., Dwyer, D. F., Jones, T. G., Bankova, L. G., Shen, S., Katz, H. R., Austen, K. F., & Gurish, M. F.
Affiliations
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA 02115
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2013-02
Volume
190
Issue
4
Pages
1758-1766
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1202567
PMC
PMC3563837
Cited by
39
References
0
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review