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Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
Abstract
Basophils and mast cells, which are selectively endowed with the high-affinity IgE receptor and mediate a range of adaptive and innate immune responses, have an unknown developmental relationship. Here, by evaluating the expression of the β7 integrin, a molecule that is required for selective homing of mast cell progenitors (MCPs) to the periphery, we identified bipotent progenitors that are capable of differentiating into either cell type in the mouse spleen. These basophil/mast cell progenitors (BMCPs) gave rise to basophils and mast cells at the single-cell level and reconstituted both mucosal and connective tissue mast cells. We also identified the basophil progenitor (BaP) and the MCP in the bone marrow and the gastrointestinal mucosa, respectively. We further show that the granulocyte-related transcription factor CCAAT/enhancer-binding protein α (C/EBPα) plays a primary role in the fate decision of BMCPs, being expressed in BaPs but not in MCPs. Thus, circulating basophils and tissue mast cells share a common developmental stage at which their fate decision might be controlled principally by C/EBPα.
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“Indeed, mast cell progenitors are also present in the spleen 104 and murine adipose tissues, 105 to which the latter are mobilized upon experimental myocardial infarction. 106”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [104]
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Metadata
- Authors
- Arinobu, Y., Iwasaki, H., Gurish, M. F., Mizuno, S.-I., Shigematsu, H., Ozawa, H., Tenen, D. G., Austen, K. F., & Akashi, K.
- Affiliations
- Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Harvard Institute of Medicine, Harvard Medical School, Boston, MA 02115; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan; and Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-12-05
- Volume
- 102
- Issue
- 50
- Pages
- 18105-18110
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 305
- References
- 5
- Language
- en
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- Arinobu, Y., Iwasaki, H., Gurish, M. F., Mizuno, S.-I., Shigematsu, H., Ozawa, H., Tenen, D. G., Austen, K. F., & Akashi, K. (2005). Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0509148102
