The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Maresin 1, a Proresolving Lipid Mediator Derived from Omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis
Abstract
It has been previously reported that dietary fish oils, which are rich in the polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, can exert beneficial effects in inflammatory bowel disease. In this study, we investigated the effects of docosahexaenoic acid–derived lipid mediator maresin 1 (MaR1) in dextran sulfate sodium (DSS)– and 2,4,6-trinitrobenzenesulfonic acid–induced colitis in mice. Systemic treatment with MaR1 significantly attenuated both DSS- and 2,4,6-trinitrobenzene sulfonic acid–induced colonic inflammation by improving the disease activity index and reducing body weight loss and colonic tissue damage. MaR1 treatment also induced a significant decrease in levels of inflammatory mediators, such as IL-1β, TNF-α, IL-6, and IFN-γ, in the acute protocol, as well as IL-1β and IL-6, but not TNF-α and INF-γ, in the chronic DSS colitis protocol. Additionally, MaR1 decreased ICAM-1 mRNA expression in both the acute and chronic protocols of DSS-induced colitis. Furthermore, the beneficial effects of MaR1 seem to be associated with inhibition of the NF-κB pathway. Moreover, incubation of LPS-stimulated bone marrow–derived macrophage cultures with MaR1 reduced neutrophil migration and reactive oxygen species production, besides decreasing IL-1β, TNF-α, IL-6, and INF-γ production. Interestingly, macrophages incubated only with MaR1 showed a significant upregulation of mannose receptor C, type 1 mRNA expression, an M2 macrophage phenotype marker. These results indicate that MaR1 consistently protects mice against different models of experimental colitis, possibly by inhibiting the NF-κB pathway and consequently multiple inflammatory mediators, as well as by enhancing the macrophage M2 phenotype.
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Citations
Cites
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“These endogenous mediators, which are biosynthesized in situ, such as lipoxins, resolvins, and protectins, are thought to exert a critical role in triggering the resolution of inflammation (1, 5), accelerating the uptake of apoptotic leukocytes by macrophages in a nonphlogistic fashion and switching from a proinflamma…”
BackgroundAlternative Activation of Macrophages: An Immunologic Functional Perspective
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Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions
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Cited by
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900
Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492
Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance
Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03160 · Cited by 481
DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation
Duvall, M. G., & Levy, B. D. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.001 · Cited by 286
Metadata
- Authors
- Marcon, R., Bento, A. F., Dutra, R. C., Bicca, M. A., Leite, D. F. P., & Calixto, J. B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10
- Volume
- 191
- Issue
- 8
- Pages
- 4288-4298
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1670356458
- Cited by
- 293
- References
- 12
- FWCI
- 31.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marcon, R., Bento, A. F., Dutra, R. C., Bicca, M. A., Leite, D. F. P., & Calixto, J. B. (2013). Maresin 1, a Proresolving Lipid Mediator Derived from Omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1202743
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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