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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

BAIN, G·1994·Cell
DOI 10.1016/0092-8674(94)90077-9
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Abstract

E12 and E47 are two helix-loop-helix transcription factors that arise by alternative splicing of the E2A gene. Both have been implicated in the regulation of immunoglobulin gene expression. We have now generated E2A (-/-) mice by gene targeting. E2A-null mutant mice fail to generate mature B cells. The arrest of B cell development occurs at an early stage, since no immunoglobulin DJ rearrangements can be detected in homozygous mutant mice. While immunoglobulin germline I mu RAG-1, mb-1, CD19, and lambda 5 transcripts are dramatically reduced in fetal livers of E2A (-/-) mice, B29 and mu degrees transcripts are present, but at lower levels. In addition, we show that Pax-5 transcripts are significantly reduced in fetal livers of E2A (-/-) mice. These data suggest a crucial role for E2A products as central regulators in early B cell differentiation.

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  • Developmental progression of B cells is critically dependent on activity of various transcription factors binding to promoter and enhancer elements of Ig genes.

    “In fact, gene-targeting studies indicate that the developmental progression of B cells is critically dependent on the activity of various transcription factors, which bind to promoter and enhancer elements of Ig genes (heavy and light chains), suggesting a link between the signal transduction and transcription factors during B-cell development (13-18”

    From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [15]

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Metadata

Authors
BAIN, G.
Venue
Cell
Publisher
Elsevier BV
Published
1994-12
Volume
79
Issue
5
Pages
885-892
ISSN
0092-8674
DOI
10.1016/0092-8674(94)90077-9
Cited by
635
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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