The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Immunotherapy of malignancy by in vivo gene transfer into tumors.
Open accessAbstract
The immune system confers protection against a variety of pathogens and contributes to the surveillance and destruction of neoplastic cells. Several cell types participate in the recognition and lysis of tumors, and appropriate immune stimulation provides therapeutic effects in malignancy. Foreign major histocompatibility complex (MHC) proteins also serve as a potent stimulus to the immune system. In this report, a foreign MHC gene was introduced directly into malignant tumors in vivo in an effort to stimulate tumor rejection. In contrast to previous attempts to induce tumor immunity by cell-mediated gene transfer, the recombinant gene was introduced directly into tumors in vivo. Expression of the murine class I H-2Ks gene within the CT26 mouse colon adenocarcinoma (H-2Kd) or the MCA 106 fibrosarcoma (H-2Kb) induced a cytotoxic T-cell response to H-2Ks and, more importantly, to other antigens present on unmodified tumor cells. This immune response attenuated tumor growth and caused complete tumor regression in many cases. Direct gene transfer in vivo can therefore induce cell-mediated immunity against specific gene products, which provides an immunotherapeutic effect for malignancy, and potentially can be applied to the treatment of cancer and infectious diseases in man.
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A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes
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A novel cationic liposome reagent for efficient transfection of mammalian cells
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Self-citationSarmiento, M., Glasebrook, A. L., & Fitch, F. W. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.6.2665 · Cited by 802
Murine interleukin-4 displays potent anti-tumor activity in vivo
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Site-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall
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Self-citationTumor-specific cytolysis by lymphocytes infiltrating human melanomas.
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Cited by
High-efficiency gene transfer into skeletal muscle mediated by electric pulses
Mir, L. M., Bureau, M. F., Gehl, J., Rangara, R., Rouy, D., Caillaud, J.-M., Delaere, P., Branellec, D., Schwartz, B., & Scherman, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4262 · Cited by 914
Jooss, K., Yang, Y., Fisher, K. J., & Wilson, J. M. (1998) · Journal of Virology · doi:10.1128/jvi.72.5.4212-4223.1998 · Cited by 470
Paracrine Cytokine Adjuvants in Cancer Immunotherapy
Pardoll, D. M. (1995) · Annual Review of Immunology · doi:10.1146/annurev.immunol.13.1.399 · Cited by 369
Metadata
- Authors
- Plautz, G. E., Yang, Z. Y., Wu, B. Y., Gao, X., Huang, L., & Nabel, G. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-05-15
- Volume
- 90
- Issue
- 10
- Pages
- 4645-4649
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996671893
- Cited by
- 317
- References
- 28
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Plautz, G. E., Yang, Z. Y., Wu, B. Y., Gao, X., Huang, L., & Nabel, G. J. (1993). Immunotherapy of malignancy by in vivo gene transfer into tumors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.10.4645
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
