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Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.
Abstract
Recombinant murine interleukin 1 (rIL 1) inhibits 3T3-L1 cell expression of lipoprotein lipase (LPL) activity when present in exceedingly dilute concentration (less than 10(-15) M). The extreme sensitivity of the adipocyte system to rIL 1 far exceeds that of the standard lymphocyte-activating factor assay. However, enzyme suppression is incomplete; even at micromolar concentrations, rIL 1 causes only about a 50% reduction in LPL activity. By contrast, cachectin (tumor necrosis factor) achieves nearly complete LPL suppression at subnanomolar concentrations. Concentrated solutions of rIL 1 are incapable of competing with radiolabeled cachectin for binding sites on 3T3-L1 cells. rIL 1-induced LPL suppression is abolished by the addition of a specific IL 1 neutralizing antiserum to the assay system. rIL 1 appears capable of influencing adipocyte expression of LPL, but apparently acts through a different mechanism than cachectin/TNF.
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Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472
Self-citationTumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage
Saklatvala, J. (1986) · Nature · doi:10.1038/322547a0 · Cited by 745
Rock, C. S., & Lowry, S. F. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90146-d · Cited by 503
Feingold, K., Staprans, I., Memon, R., Moser, A., Shigenaga, J., Doerrler, W., Dinarello, C., & Grunfeld, C. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41334-3 · Cited by 346
Metadata
- Authors
- Beutler, B. A., & Cerami, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-12-01
- Volume
- 135
- Issue
- 6
- Pages
- 3969-3971
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1634034367
- Cited by
- 232
- References
- 0
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beutler, B. A., & Cerami, A. (1985). Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.135.6.3969
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