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IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.
Abstract
Human rIL-6, produced either in COS cells or Escherichia coli, similarly stimulates the production of acute phase plasma proteins in cultured human and rat hepatoma cells. This anabolic effect in hepatoma cells suggested a potential in vivo role of the cytokine in mediating the hepatic response to inflammation. Injection of IL-6 into adult male rats elicited a cytokine-specific change in the liver expression of acute phase proteins. As predicted from in vitro studies, glucocorticoids were needed to achieve a maximal IL-6 response in vivo. Optimal conditions were found to be two i.p. injections of 35 to 120 micrograms IL-6 and 65 micrograms dexamethasone per kg body weight administered at 12-h intervals. Within 24 h, the plasma concentrations for alpha 2-macroglobulin, fibrinogen, thiostatin, and hemopexin were increased to levels approximating those observed in acute phase animals. These results support the notion that direct interaction of IL-6 with the liver is an essential part in initiating the hepatic acute phase reaction.
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Citations
Cited by
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism
Docter, R., Krenning, E. P., de Jong, M., & Hennemann, G. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02401.x · Cited by 345
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman’s disease in mice
Brandt, S. J., Bodine, D. M., Dunbar, C. E., & Nienhuis, A. W. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114749 · Cited by 248
Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6
Oldenburg, H. S. A., Rogy, M. A., Lazarus, D. D., van Zee, K. J., Keeler, B. P., Chizzonite, R. A., Lowry, S. F., & Moldawer, L. L. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230824 · Cited by 155
Skelly, D. T., Hennessy, E., Dansereau, M.-A., & Cunningham, C. (2013) · PLoS ONE · doi:10.1371/annotation/90c76048-2edd-4315-8404-4d9d8cbd411e · Cited by 77
Metadata
- Authors
- Marinkovic, S., Jahreis, G. P., Wong, G. G., & Baumann, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-02-01
- Volume
- 142
- Issue
- 3
- Pages
- 808-812
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1570782716
- Cited by
- 298
- References
- 0
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marinkovic, S., Jahreis, G. P., Wong, G. G., & Baumann, H. (1989). IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. The Journal of Immunology. https://doi.org/10.4049/jimmunol.142.3.808
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
