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Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man.
Abstract
beta 2-IFN/hepatocyte stimulating factor/IL-6 is a cytokine secreted by monocytes, fibroblasts, and endothelial cells in cell culture that possesses diverse biologic activity including the stimulation of acute phase plasma protein synthesis and immunomodulation. The circulating levels of this cytokine in man in response to bacterial LPS (endotoxin) were studied. A single i.v. bolus of endotoxin (20 U/kg) produced a monophasic rise in circulating immunoreactive IFN-beta 2/IL-6 and IFN-beta 2/IL-6 bioactivity (hepatocyte stimulation and B cell differentiation assays) peaking 2 to 4 h after the endotoxin challenge. Peak IFN-beta 2/IL-6 levels ranged from 4.1 to 27.5 ng/ml. Associated with this was a rise in circulating C-reactive protein levels detected 20 h after the endotoxin bolus. Thus, IFN-beta 2/IL-6 is likely one of the endogenous mediators which is triggered in man during bacterial infection and likely participates in the metabolic and immune responses of the infected host.
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Citations
Cited by
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Grossman, R. M., Krueger, J., Yourish, D., Granelli-Piperno, A., Murphy, D. P., May, L. T., Kupper, T. S., Sehgal, P. B., & Gottlieb, A. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6367 · Cited by 853
Self-citationInterleukin-6 and its receptors: a highly regulated and dynamic system
Wolf, J., Rose-John, S., & Garbers, C. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.024 · Cited by 618
JEUKENDRUP, A. E., VET-JOOP, K., STURK, A., STEGEN, J. H. J. C., SENDEN, J., SARIS, W. H. M., & WAGENMAKERS, A. J. M. (2000) · Clinical Science · doi:10.1042/cs0980047 · Cited by 371
INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASE IN VITRO.
SPANGELO, B. L., JUDD, A. M., ISAKSON, P. C., & MACLEOD, R. M. (1989) · Endocrinology · doi:10.1210/endo-125-1-575 · Cited by 320
Metadata
- Authors
- Fong, Y., Moldawer, L. L., Marano, M., Wei, H., Tatter, S. B., Clarick, R. H., Santhanam, U., Sherris, D., May, L. T., Sehgal, P. B., & Lowry, S. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-04-01
- Volume
- 142
- Issue
- 7
- Pages
- 2321-2324
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2163254761
- Cited by
- 319
- References
- 0
- FWCI
- 20.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fong, Y., Moldawer, L. L., Marano, M., Wei, H., Tatter, S. B., Clarick, R. H., Santhanam, U., Sherris, D., May, L. T., Sehgal, P. B., & Lowry, S. F. (1989). Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man. The Journal of Immunology. https://doi.org/10.4049/jimmunol.142.7.2321
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