The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASE IN VITRO.
Abstract
Interleukin-6 (IL-6), a cytokine produced by inflammatory reactions, was found to stimulate PRL, GH and LH release from anterior pituitary cells at concentrations similar to those which affected lymphocyte mitogenesis. Perifused pituitary cells responded to IL-6 with prompt increases in hormone release that declined rapidly following cessation of exposure. Dopamine (DA) attenuated IL6-induced PRL release. In addition, IL-6 potentiated both GHRF- and TRH-induced hormone release without an affect on intracellular cAMP. These data demonstrate a new biological activity for IL-6 and provide evidence for immune system regulation of anterior pituitary hormone release.
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Cites
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Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
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Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
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Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells
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Molecular Regulation of B Lymphocyte Response
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Growth Hormone-Releasing Hormone*
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Cited by
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Interleukin-6 and its receptor: a paradigm for cytokines
Kishimoto, T., Akira, S., & Taga, T. (1992) · Science · doi:10.1126/science.1411569 · Cited by 665
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582
Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6
Zalcman, S., Green-Johnson, J. M., Murray, L., Nance, D. M., Dyck, D., Anisman, H., & Greenberg, A. H. (1994) · Brain Research · doi:10.1016/0006-8993(94)90006-x · Cited by 439
Metadata
- Authors
- SPANGELO, B. L., JUDD, A. M., ISAKSON, P. C., & MACLEOD, R. M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1989-07
- Volume
- 125
- Issue
- 1
- Pages
- 575-577
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2074357767
- Cited by
- 320
- References
- 19
- FWCI
- 17.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASE IN VITRO. https://app.cochat.ai/papers/10.1210/endo-125-1-575
- The paper
- SPANGELO, B. L., JUDD, A. M., ISAKSON, P. C., & MACLEOD, R. M. (1989). INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASE IN VITRO. Endocrinology. https://doi.org/10.1210/endo-125-1-575
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
