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IL-10 inhibits human T cell proliferation and IL-2 production
Abstract
Human IL-10 has been reported previously to inhibit the secretion of IFN-gamma in PBMC. In this study, we have found that human IL-10 inhibits T cell proliferation to either mitogen or anti-CD3 mAb in the presence of accessory cells. Inhibited T cell growth by IL-10 was associated with reduced production of IFN-gamma and IL-2. Studies of T cell subset inhibition by human IL-10 showed that CD4+, CD8+, CD45RA high, and CD45RA low cells are all growth inhibited to a similar degree. Dose response experiments demonstrated that IL-10 inhibits secretion of IFN-gamma more readily than T cell proliferation to mitogen. In addition, IL-2 and IL-4 added exogenously to IL-10 suppressed T cell cultures reversed completely the inhibition of T cell proliferation, but had little or no effect on inhibition of IFN-gamma production. Thus, in addition to its previously reported biologic properties, IL-10 inhibits human T cell proliferation and IL-2 production in response to mitogen. Inhibition of IFN-gamma production by IL-10 appears to be independent of the cytokine effect of IL-2 production.
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Citations
Cited by
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Metadata
- Authors
- Taga, K., & Tosato, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-02
- Volume
- 148
- Issue
- 4
- Pages
- 1143-1148
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1639400191
- Cited by
- 482
- References
- 0
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taga, K., & Tosato, G. (1992). IL-10 inhibits human T cell proliferation and IL-2 production. The Journal of Immunology. https://doi.org/10.4049/jimmunol.148.4.1143
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