T cell responses in patients with COVID-19
Open accessAbstract
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting to enable some general concepts to emerge.
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For SARS-CoV-2, increasing evidence indicates that T cells play a major role in the resolution of COVID-19.
“For SARS-CoV-2, increasing evidence indicates that T cells play a major role in the resolution of COVID-19,28, 29”
From Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial (2022) · cites this paper as [29]
The Conclusions (page unavailable) say accumulating evidence supports a role for T cells in COVID-19. But the Abstract says their role in resolving or exacerbating disease remains debated, and the CD8+ T cell section says an association with recovery may be a cause or a consequence. The source therefore does not establish a major role in resolution. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFollowing infection, both lower and higher CD8+ and CD4+ T cell responses have been reported.
“Both reduced and increased CD8+ and CD4+ T cell responses have been observed following infection41.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [41]
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COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
Ren, X., Wen, W., Fan, X., Hou, W., Su, B., Cai, P., Li, J., Liu, Y., Tang, F., Zhang, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.053 · Cited by 865 · see citing works
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Sadarangani, M., Marchant, A., & Kollmann, T. R. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00578-z · Cited by 560 · see citing works
COVID-19 vaccines: The status and perspectives in delivery points of view
Chung, J. Y., Thone, M. N., & Kwon, Y. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.011 · Cited by 375 · see citing works
Bacher, P., Rosati, E., Esser, D., Martini, G. R., Saggau, C., Schiminsky, E., Dargvainiene, J., Schröder, I., Wieters, I., Khodamoradi, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.016 · Cited by 314 · see citing works
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., Ansari, M. A., Arancibia-Cárcamo, C. V., Aschenbrenner, D., Attar, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.012 · Cited by 328 · see citing works
Mastellos, D. C., Pires da Silva, B. G. P., Fonseca, B. A. L., Fonseca, N. P., Auxiliadora-Martins, M., Mastaglio, S., Ruggeri, A., Sironi, M., Radermacher, P., Chrysanthopoulou, A., et al. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108598 · Cited by 255 · see citing works
Immunology of stress: A review article
Alotiby, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216394 · Cited by 253 · see citing works
Persistent cellular immunity to SARS-CoV-2 infection
Breton, G., Mendoza, P., Hägglöf, T., Oliveira, T. Y., Schaefer-Babajew, D., Gaebler, C., Turroja, M., Hurley, A., Caskey, M., & Nussenzweig, M. C. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20202515 · Cited by 129 · see citing works
Gangaev, A., Ketelaars, S. L. C., Isaeva, O. I., Patiwael, S., Dopler, A., Hoefakker, K., De Biasi, S., Gibellini, L., Mussini, C., Guaraldi, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22811-y · Cited by 111 · see citing works
COVID-19 makes B cells forget, but T cells remember
Cañete, P. F., & Vinuesa, C. G. (2020) · Cell · doi:10.1016/j.cell.2020.09.013 · Cited by 83 · see citing works
Chen, G.-L., Li, X.-F., Dai, X.-H., Li, N., Cheng, M.-L., Huang, Z., Shen, J., Ge, Y.-H., Shen, Z.-W., Deng, Y.-Q., et al. (2022) · The Lancet Microbe · doi:10.1016/s2666-5247(21)00280-9 · Cited by 82 · see citing works
- Authors
- Chen, Z., & John Wherry, E.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Nature Reviews Immunology
- Published
- 2020-07-29
- Volume
- 20
- Issue
- 9
- Pages
- 529-536
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC7389156
- OpenAlex
- W3046194290
- Cited by
- 797
- References
- 79
- Citations by year
- 2026: 17 · 2025: 41 · 2024: 63 · 2023: 97 · 2022: 191 · 2021: 305 · 2020: 83
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Parker Institute for Cancer Immunotherapy
- Allen Institute for Immunology
- National Institutes of Health (CA234842, AI082630)
- National Cancer Institute (K00CA234842, F99CA234842)
- National Institute of Allergy and Infectious Diseases (U19AI082630)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- T cell response, COVID-19 pandemic, SARS-CoV-2, disease phenotypes, immune response heterogeneity, reinfection protection, disease severity
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