The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Late Complications of Immune Deviation Therapy in a Nonhuman Primate
Abstract
The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (T H 1) to a T H 2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.
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Cites
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Self-citationTh1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
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Cited by
The immunology of stroke: from mechanisms to translation
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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
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Metadata
- Authors
- Genain, C. P., Abel, K., Belmar, N., Villinger, F., Rosenberg, D. P., Linington, C., Raine, C. S., & Hauser, S. L.
- Venue
- Science
- Published
- 1996-12-20
- Volume
- 274
- Issue
- 5295
- Pages
- 2054-2057
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075963617
- Cited by
- 320
- References
- 40
- FWCI
- 29.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Genain, C. P., Abel, K., Belmar, N., Villinger, F., Rosenberg, D. P., Linington, C., Raine, C. S., & Hauser, S. L. (1996). Late Complications of Immune Deviation Therapy in a Nonhuman Primate. Science. https://doi.org/10.1126/science.274.5295.2054
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
