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Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells
Abstract
The infiltration of the glomerulus by monocyte-derived macrophages is an important step in the pathogenesis of glomerular injury. The factors regulating glomerular leukocyte traffic remain unknown. We postulated that the glomerular mesangial cell (MC) may participate in the development of glomerular inflammation through the production of the monocyte-specific chemotactic factor, monocyte chemoattractant protein-1 (MCP-1). Using a cell culture system, we found that human MC produced a basal level of monocyte chemotactic activity, which was significantly increased by the inflammatory cytokines IL-1 beta and TNF-alpha. This increase in bioactivity correlated with the increased expression of MCP-1 mRNA by cytokine-conditioned MC. The total chemotactic activity of MC-conditioned supernatants was reduced by more than 80% after immunoadsorption with a specific anti-MCP-1 antibody. Thus, MC could play a role in inflammatory glomerular conditions through the production of MCP-1.
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Cited by
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Mantovani, A., Bussolino, F., & Dejana, E. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.8.1592209 · Cited by 678
Tesch, G. H. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00016.2008 · Cited by 417
Martin, T., Cardarelli, P. M., Parry, G. C. N., Felts, K. A., & Cobb, R. R. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270508 · Cited by 317
Nonsteroidal Anti-Inflammatory Drugs and the Kidney
Hörl, W. H. (2010) · Pharmaceuticals · doi:10.3390/ph3072291 · Cited by 298
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation
Piemonti, L., Leone, B. E., Nano, R., Saccani, A., Monti, P., Maffi, P., Bianchi, G., Sica, A., Peri, G., Melzi, R., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.1.55 · Cited by 287
Metadata
- Authors
- Rovin, B. H., Yoshiumura, T., & Tan, L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-04-01
- Volume
- 148
- Issue
- 7
- Pages
- 2148-2153
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1673986181
- Cited by
- 199
- References
- 0
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rovin, B. H., Yoshiumura, T., & Tan, L. (1992). Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.148.7.2148
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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