The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication
Abstract
Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis. To investigate this pathway in the host response to M. tuberculosis, we performed metabolic and functional studies on human alveolar macrophages, human monocyte-derived macrophages, and murine bone marrow–derived macrophages following infection with the bacillus in vitro. M. tuberculosis infection induced a shift from oxidative phosphorylation to aerobic glycolysis in macrophages. Inhibition of this shift resulted in decreased levels of proinflammatory IL-1β and decreased transcription of PTGS2, increased levels of anti-inflammatory IL-10, and increased intracellular bacillary survival. Blockade or absence of IL-1R negated the impact of aerobic glycolysis on intracellular bacillary survival, demonstrating that infection-induced glycolysis limits M. tuberculosis survival in macrophages through induction of IL-1β. Drugs that manipulate host metabolism may be exploited as adjuvants for future therapeutic and vaccination strategies.
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Cites
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
Self-citationmTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
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Self-citationPalsson-McDermott, E. M., Curtis, A. M., Goel, G., Lauterbach, M. A. R., Sheedy, F. J., Gleeson, L. E., van den Bosch, M. W. M., Quinn, S. R., Domingo-Fernandez, R., Johnston, D. G. W., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.005 · Cited by 1,397
Self-citationToll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
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Targeting lactate metabolism for cancer therapeutics
Doherty, J. R., & Cleveland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69741 · Cited by 1,166
Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells
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Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
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Immunometabolism: an emerging frontier
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Cited by
Biology and therapeutic potential of interleukin-10
Saraiva, M., Vieira, P., & O’Garra, A. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190418 · Cited by 1,118
The role of HIF in immunity and inflammation
McGettrick, A. F., & O’Neill, L. A. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.002 · Cited by 768
Self-citationCompetition for nutrients and its role in controlling immune responses
Kedia-Mehta, N., & Finlay, D. K. (2019) · Nature Communications · doi:10.1038/s41467-019-10015-4 · Cited by 287
Weerasinghe, H., Simm, C., Djajawi, T. M., Tedja, I., Lo, T. L., Simpson, D. S., Shasha, D., Mizrahi, N., Olivier, F. A. B., Speir, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112522 · Cited by 47
Metadata
- Authors
- Gleeson, L. E., Sheedy, F. J., Palsson-McDermott, E. M., Triglia, D., O’Leary, S. M., O’Sullivan, M. P., O’Neill, L. A. J., & Keane, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03
- Volume
- 196
- Issue
- 6
- Pages
- 2444-2449
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2271668642
- Cited by
- 319
- References
- 22
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication. https://app.cochat.ai/papers/10.4049/jimmunol.1501612
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- Gleeson, L. E., Sheedy, F. J., Palsson-McDermott, E. M., Triglia, D., O’Leary, S. M., O’Sullivan, M. P., O’Neill, L. A. J., & Keane, J. (2016). Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1501612
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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