ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion

Lipid rafts and signal transduction

Simons, K., & Toomre, D. K. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 6,252 · see citing works

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,110 · see citing works

Three-dimensional segregation of supramolecular activation clusters in T cells

Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N., & Kupfer, A. (1998) · Nature · doi:10.1038/25764 · Cited by 2,353 · see citing works

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

Brown, D. A., & London, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000005200 · Cited by 2,344 · see citing works

T Cell Activation

Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144 · see citing works

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/341619a0 · Cited by 1,547 · see citing works

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

Takagi, J., Petre, B. M., Walz, T., & Springer, T. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00935-2 · Cited by 1,168 · see citing works

The Immunological Synapse

Bromley, S. K., Burack, R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979 · see citing works

Identification of a Putative Regulator of Early T Cell Activation Genes

Shaw, J., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., & Crabtree, G. R. (1988) · Science · doi:10.1126/science.3260404 · Cited by 946 · see citing works

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

Janes, P. W., Ley, S. C., & Magee, A. I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.447 · Cited by 797 · see citing works

Intracellular signalling controlling integrin activation in lymphocytes

Kinashi, T. (2005) · Nature reviews. Immunology · doi:10.1038/nri1646 · Cited by 555 · see citing works

Electroporation in ‘intracellular’ buffer increases cell survival

van den Hoff, M. J. B., Moorman, A. F. M., & Lamers, W. H. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.11.2902 · Cited by 449 · see citing works

Regulation of T-cell activation by the cytoskeleton

Billadeau, D. D., Nolz, J. C., & Gomez, T. S. (2007) · Nature reviews. Immunology · doi:10.1038/nri2021 · Cited by 389 · see citing works

TCR signal initiation machinery is pre‐assembled and activated in a subset of membrane rafts

Drevot, P., Langlet, C., Guo, X., Bernard, A., Colard, O., Chauvin, J., Lasserre, R., & He, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.8.1899 · Cited by 330 · see citing works

Tuning immune responses: diversity and adaptation of the immunological synapse

Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature reviews. Immunology · doi:10.1038/nri1647 · Cited by 318 · see citing works

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

Peterson, E. J., Woods, M. L., Dmowski, S. A., Derimanov, G. S., Jordan, M. S., Wu, J. N., Myung, P. S., Liu, Q., Pribila, J. T., Freedman, B. D., et al. (2001) · Science · doi:10.1126/science.1063486 · Cited by 318 · see citing works

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

Griffiths, E. K., Krawczyk, C. M., Kong, Y., Raab, M., Hyduk, S. J., Bouchard, D., Chan, V. S. F., Kozieradzki, I., Oliveira-dos-Santos, A., Wakeham, A. C., et al. (2001) · Science · doi:10.1126/science.1063397 · Cited by 282 · see citing works

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

da Silva, A. J., Li, Z., de Vera, C., canto, E., Findell, P. R., & Rudd, C. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7493 · Cited by 266 · see citing works

Adaptors and Molecular Scaffolds in Immune Cell Signaling

Rudd, C. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80953-8 · Cited by 223 · see citing works

Floating the Raft Hypothesis

Cherukuri, A., Dykstra, M. L., & Pierce, S. K. (2001) · Immunity · doi:10.1016/s1074-7613(01)00156-x · Cited by 223 · see citing works

The Actin Cytoskeleton and Lymphocyte Activation

Penninger, J. M., & Crabtree, G. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80954-x · Cited by 220 · see citing works

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

Villalba, M., Bi, K., Rodrı́guez, F., Tanaka, Y., Schoenberger, S. P., & Altman, A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107080 · Cited by 220 · see citing works

INTEGRATION OF T CELL RECEPTOR–DEPENDENT SIGNALING PATHWAYS BY ADAPTER PROTEINS

Clements, J. L., Boerth, N. J., Lee, J. R., & Koretzky, G. A. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.89 · Cited by 191 · see citing works

The Cellular Context of T Cell Signaling

Dustin, M. L. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.010 · Cited by 161 · see citing works

Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC‐MS/MS

Heo, S.-H., Lee, S.-J., Ryoo, H., Park, J.-Y., & Cho, J.-Y. (2007) · Proteomics · doi:10.1002/pmic.200700433 · Cited by 158 · see citing works

Immune synapses in T-cell activation

Čemerski, S., & Shaw, A. S. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.011 · Cited by 137 · see citing works

Cutting Edge: Quantitative Imaging of Raft Accumulation in the Immunological Synapse

Burack, R., Lee, K., Holdorf, A. D., Dustin, M. L., & Shaw, A. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2837 · Cited by 136 · see citing works

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

Liu, J., Kang, H. K., Raab, M., da Silva, A. J., Kraeft, S., & Rudd, C. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8779 · Cited by 133 · see citing works

The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1

Kliche, S., Breitling, D., Togni, M., Pusch, R., Heuer, K., Wang, X., Freund, C., Kasirer‐Friede, A., Ménasché, G., Koretzky, G. A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00331-06 · Cited by 128 · see citing works

T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

Raab, M., Wang, H., Lu, Y., Smith, X., Wu, Z., Strebhardt, K., Ladbury, J. E., & Rudd, C. E. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.007 · Cited by 113 · see citing works

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1

Nolz, J. C., Nacusi, L. P., Segovis, C. M., Medeiros, R. B., Mitchell, J. S., Shimizu, Y., & Billadeau, D. D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801121 · Cited by 108 · see citing works

Regulation of NF-κB Activation in T Cells via Association of the Adapter Proteins ADAP and CARMA1

Medeiros, R. B., Burbach, B. J., Mueller, K. L., Srivastava, R., Moon, J. J., Highfill, S., Peterson, E. J., & Shimizu, Y. (2007) · Science · doi:10.1126/science.1137895 · Cited by 101 · see citing works

SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion

Wang, H.-Y., & Rudd, C. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.005 · Cited by 98 · see citing works

FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells

Raab, M., Kang, H. K., da Silva, A., Zhu, X., & Rudd, C. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21170 · Cited by 98 · see citing works

ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation

Wang, H., McCann, F. E., Gordan, J. D., Wu, X., Raab, M., Malik, T. H., Davis, D. M., & Rudd, C. E. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040780 · Cited by 96 · see citing works

SKAP‐HOM, a novel adaptor protein homologous to the FYN‐associated protein SKAP551

Marie‐Cardine, A., Verhagen, A. M., Eckerskorn, C., & Schraven, B. L. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01040-0 · Cited by 84 · see citing works

Cutting Edge: SLP-76 Cooperativity with FYB/FYN-T in the Up-Regulation of TCR-Driven IL-2 Transcription Requires SLP-76 Binding to FYB at Tyr595 and Tyr651

Geng, L., Raab, M., & Rudd, C. E. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5753 · Cited by 68 · see citing works

Functional Association between SLAP-130 and SLP-76 in Jurkat T Cells

Boerth, N. J., Judd, B. A., & Koretzky, G. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5143 · Cited by 57 · see citing works

Functional Cooperation between the Proteins Nck and ADAP Is Fundamental for Actin Reorganization

Pauker, M. H., Reicher, B., Fried, S., Perl, O., & Barda‐Saad, M. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01358-10 · Cited by 57 · see citing works

Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells

Huang, Y., Norton, D. D., Precht, P., Martindale, J. L., Burkhardt, J. K., & Wange, R. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413201200 · Cited by 55 · see citing works

Functional Defects of SKAP-55-Deficient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion

Wang, H., Liu, H., Lu, Y., Lovatt, M., Wei, B. K., & Rudd, C. E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00556-07 · Cited by 54 · see citing works

PRAM-1 Is a Novel Adaptor Protein Regulated by Retinoic Acid (RA) and Promyelocytic Leukemia (PML)-RA Receptor α in Acute Promyelocytic Leukemia Cells

Moog‐Lutz, C., Peterson, E. J., Lutz, P. G., Eliason, S. L., Riant, F., Singer, A. L., Gioia, Y. D., Dmowski, S. A., Kamens, J., Cayre, Y. E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011683200 · Cited by 52 · see citing works

Role of Two Adaptor Molecules SLP-76 and LAT in the PI3K Signaling Pathway in Activated T Cells

Shim, E. K., Jung, S. H., & Lee, J. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001785 · Cited by 46 · see citing works

Identification of diabetic nephropathy‐selective proteins in human plasma by multi‐lectin affinity chromatography and LC‐MS/MS

Ahn, J., Kim, B., Yu, M., Lee, I. K., & Cho, J. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900196 · Cited by 36 · see citing works

Association of the Src homology 2 domain‐containing leukocyte phosphoprotein of 76 kD (SLP‐76) with the p85 subunit of phosphoinositide 3‐kinase

Shim, E. K., Moon, C., Lee, G. Y., Ha, Y. J., Chae, S., & Lee, J. R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.090 · Cited by 35 · see citing works

ADAP-ting TCR Signaling to Integrins

Griffiths, E. K., & Penninger, J. M. (2002) · Science s STKE · doi:10.1126/stke.2002.127.re3 · Cited by 14 · see citing works

Competition between SLP76 and LAT for PLCγ1 binding in resting T cells

Jung, S. H., Jeong, J. H., Seul, H. J., & Lee, J. R. (2010) · European Journal of Immunology · doi:10.1002/eji.200939411 · Cited by 5 · see citing works

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events

Dadwal, N., Mix, C., Reinhold, A., Witte, A., Freund, C., Schraven, B. L., & Kliche, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.703534 · Cited by 35 · see citing works

Genome-Wide SNPs and InDels Characteristics of Three Chinese Cattle Breeds

Zhang, F., Qu, K., Chen, N., Hanif, Q., Jia, Y., Huang, Y., Dang, R., Zhang, J., Lan, X., Chen, H., et al. (2019) · Animals · doi:10.3390/ani9090596 · Cited by 22 · see citing works

Screening of key genes related to the prognosis of mouse sepsis

Chen, M., Chen, X., Hu, Y., & Cai, X. (2020) · Bioscience Reports · doi:10.1042/bsr20202649 · Cited by 17 · see citing works

The Clinical Aspect of Adaptor Molecules in T Cell Signaling: Lessons Learnt From Inborn Errors of Immunity

Dinur-Schejter, Y., Zaidman, I., Mor‐Shaked, H., & Stepensky, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.701704 · Cited by 14 · see citing works

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity

Hodgson, R., Crockford, T. L., Bhandari, A., Kepple, J. D., Back, J., Cawthorne, E., Abeler‐Dörner, L., Laing, A. G., Clare, S., Speak, A. O., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200212 · Cited by 12 · see citing works

Altered Cellular Immunity and Differentially Expressed Immune-Related Genes in Patients With Systemic Sclerosis–Associated Pulmonary Arterial Hypertension

Tu, J., Jin, J., Chen, X., Sun, L., & Cai, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.868983 · Cited by 12 · see citing works

Association between host genetics of sheep and the rumen microbial composition

Mani, S., Aiyegoro, O. A., & Adeleke, M. A. (2022) · Tropical Animal Health and Production · doi:10.1007/s11250-022-03057-2 · Cited by 11 · see citing works

NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

Zi, R., Shen, K., Zheng, P., Su, X., Yang, Y., Chen, Y., Dai, H., Mao, C., Lu, Y., Wang, L., et al. (2025) · The Innovation · doi:10.1016/j.xinn.2024.100783 · Cited by 8 · see citing works

The Landscape of Cell Death Processes with Associated Immunogenic and Fibrogenic Effects in Arrhythmogenic Cardiomyopathy

Lu, W., Rao, Y., Li, Y., Dai, Y., & Chen, K. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9090301 · Cited by 7 · see citing works

Copy number variants selected during pig domestication inferred from whole genome resequencing

Zhang, W., Xu, C., Zhou, M., Liu, L., Ni, Z., Su, S., & Wang, C. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1364267 · Cited by 7 · see citing works

ADAP-METTL3 modulates the inflammatory responses of macrophages via m6A modification of Spry1

Dong, A., Zhang, P., Yang, F., Wang, Y., & Liu, H. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08008-x · Cited by 3 · see citing works

T cells in ARAP-deficient mice present defective T cell receptor signaling and reduced severity in an experimentally-induced autoimmune disease

Kim, J., Jung, S. H., Park, C., & Lee, J. R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1556616 · Cited by 2 · see citing works

A novel adaptor protein, ARAP , orchestrates Fcγ receptor signaling in mouse dendritic cells via Rap1 activation and NF ‐ κB ‐mediated cytokine production

Park, C., Yu, M. J., & Lee, J. R. (2026) · Immunology and Cell Biology · doi:10.1111/imcb.70133 · Cited by 1 · see citing works

FYB2 Is a Potential Prognostic Biomarker for Hepatocellular Carcinoma

Qu, Y., Shen, X., Yuan, X., & Lü, B. (2022) · Livers · doi:10.3390/livers2040027 · Cited by 1 · see citing works

Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis

Wang, Y., Li, X., Lv, X., Zhang, P., & Liu, H. (2026) · Inflammation · doi:10.1007/s10753-025-02363-9

Intrinsically disordered insert from SH2D2A rewires CD19 CAR signaling via Tyr290Preprint

Borowicz, P. P., Gilmour, B. C., Chan, H., Gopalakrishnan, R. P., Peters, T., Platzer, R., Seigner, J., Visser, J. G., Kjelstrup, H., Popidou, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703491

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Li, J., Ge, Y., Du, J., Yang, L., Wu, B., Hang, C., Shen, M., Mao, Y. M., Zhang, T. B., Bo, Q., et al. (2026) · Advanced Science · doi:10.1002/advs.76582

Acute Myeloid Leukemia(AML) proteins for in silico drug design using pharmacophore modeling, molecular docking and molecular dynamics simulation

Bosu, P., Adhikary, T., Rafi, A. S., Iqbal, N., Rasool, F., & Ahmed, P. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354456

The adaptor protein ARAP contributes to Akt-dependent NF-κB p50 activation and inflammatory cytokine production in dendritic cells

Park, C., & Lee, J.-R. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05751-3

Role of a novel adaptor protein, ARAP in T cell activation

정승희 (2011)

Function of a novel adaptor protein ARAP in T cell adhesion

송현명 (2012)

The TCR ADAPts to integrin‐mediated cell adhesion

Peterson, E. J. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00026.x · Cited by 41 · see citing works

ADAP-ting TCR Signaling to Integrins

Griffiths, E. K., & Penninger, J. M. (2002) · Science Signaling · doi:10.1126/scisignal.1272002re3 · Cited by 4 · see citing works

RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation

Ménasché, G., Kliche, S., Chen, E. J. H., Stradal, T. E. B., Schraven, B. L., & Koretzky, G. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02011-06 · Cited by 124 · see citing works